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17 Cards in this Set

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  • Back
Synthesis of ACh?
Acetate + Coenzyme A =AcCoA synthetase=> acetylCoA+choline=Choline transferase=>ACh
Metabolism of ACh?
ACh=acetylcholinesterase=>choline + acetate
Focal innervated muscle fibers?
Muscle fibers that receive innervation at a single endplate region e.g. mammalian fibers
Multiply-innervated muscle fibers?
Receive dense innervation e.g. amphibia and birds
Low conc. of ACh at NMJ causes....
muscular contraction
High conc. of ACh at NMJ causes....
inhibition of muscular contraction
Non-depolarising NMJ blocking drugs? example, side effects, , MOA, revesilble
MOA - block ACh, competative antagonists
Tubocuraine - cuases paralysis
dosnt block nerve conduction or contractility
side effects - hypotension, histimine release, respiratory failure
reversered by increasing ACh (i.e. use AChEIs)
Depolarising NMJ blocking drugs? example, side effects, , MOA, revesilble
MOA - weak agonists of ACh, causes maintained depolarisation (more slowly hydrolysed by cholineserase) and loss of electricable excitablity
Side - effects - transient twitching (fasciculations)
example - suxamethonium
Gallamine?
non-depolarising NMJ blocking drug
Pancuorium?
non-depolarising NMJ blocking drug
Hexamethonium
Depolarising ganglionic blocking drug
decamethonium?
Depolarising NMJ blocking drug
Side effects of depolarising drugs? (4)
1)Bradycardia
2)K releases=>heperkalemia=>ventricular dysrythmias
3)increases intra occular pressure
4)prolonged paralysis - in patients with cholineseterase deficiency, liver disease, taking anticholinesterase drugs
Suxa vs. tubocuranine effects in chicks?
suxa - powerful extensor muscle spasm
tubocuraine - flacid paralysis
Uses of depolarising drugs?
adjuct to general aneasthesia
emergency intubation
c-section
lethal injection
How to overcome depolarising blockers?
mutual antagonism - tubocarine (non-depo) reduces depolarisation, brings membrane potential closer to threshold
How to overcome non-depolarising blockers?
AChEIs - increase ACh in synaptic cleft (may worsen depolarisng blockers)