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12 Cards in this Set
- Front
- Back
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Competative NM blocker mechanism
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compete with ACh for cholinergic receptor - Non-depolarizing
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Depolarizing NM blocker mechanism
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binds ACh receptor and initiallly cause depolarization, stays in receptor, blocking further depolarization via ACh
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Atracurium
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Non-depolarizing competitive NMB
Histamine release Hofmann elimination. |
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Vecuronium
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Non-depolarizing competitive NMB
liver metabolism clearance, renal elimination intermediate effect CV stability - no histamine - good for cardiac patients |
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Pancuronium
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Non-depolarizing competative
Renal elimination, liver metabolism LONG acting - 45 minutes. use in bilateral eye surgery - not short surgeries Mild vagolytic effect |
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Succinylcholine
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Depolarizing agent - initial excitation, followed by blockade
hydrolysis by cholinesterase, prolongs AP, Non-responsive motor end plate Short onset, short duration. NO REVERSAL agents |
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Cholinesterase inhibitor effect on Non-depolarizing NMB
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Reverse b/c competitive, increases Ach binding
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Cholinesterase inhibitor effect on Depolarizing NMB
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Enhanced - blocks metabolism of drug
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Reversal agent of Non-depolarizing agent
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Cholinesterase inhibitor
eg: neostigmine, edrophonium, pyridostigmine Binds to acetylcholinesterase allowing more acetylcholine in cleft. |
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Reversal agent of Depolarizing
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None
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Are fasciculations present with Non-depolarizing or Depolarizing agents
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Depolarizing
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Do NMB have analgesic characteristics?
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No
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