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100 Cards in this Set

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desipramine
Secondary Amine TCA
NE uptake block
imipramine
Tertiary Amine TCA
NE/5HT uptake block
mirtazapine
Anti-depressant
presynaptic alpha-2 adrenergic autoreceptors blockade
citalopram
SSRI
fluoxetine
SSRI
fluvoxamine
SSRI
paroxetine
SSRI
venlafaxine
SSRI
5HT uptake block; NE uptake block(at higher doses)
sertraline
SSRI
bupropion
DA uptake inhibitor
phenelzine
MAOI
Hepatotoxic
tranylcypromine
MAOI
alprazolam
BZ
High potency
clonazepam
BZ
High Potency
diazepam
BZ
Highest lipid solubility of BZ's
flurazepam
BZ
hypnotic
oxazepam
BZ
metabolize via conjugation
triazolam
BZ
Clomipramine
TCA chloride derivative
NE reuptake inhibitor
5HT reuptake inhibitor (OCD)
flumazenil
BZ antagonist
buspirone
azapirone
Non-BZ anti-anxiety
direct activation of 5HT1a receptor
zolpidem
Non BZ "Z" drug
zalepion
Non BZ "Z" drug
eszopiclone
Non BZ "Z" drug
chlorpromazine
typical antipsychotic
D2 antagonist
Low potency(more anticholinergic,sedation)
haloperidol
typical antipsychotic
D2 antagonist
High potency(More EPS)
cloZAPine
Atypical antipsychotic
D2/5HT antagonist
**actually decrease tardive dyskinesias from typical antipsychotic use.
granulocytopenia(weekly CBC)
risperidone
Atypical antipsychotic
D2/5HT antagonist
is not anticholinergic
Possible prolactin increase
olanzepine
Atypical antipsychotic
D2/5HT antagonist
very antihistaminic
quetiapine
Atypical antipsychotic
D2/5HT antagonist
is not anticholinergic
aripiprazole
Atypical anti-psychotic
partial D2 agonist
ziprasidone
Atypical anti-psychotic
lithium carbonate
Bipolar tx
benztropine
reduces cholinergic dominance in parkinsons
diphenhydramine
central muscarinic blockade
parkinsons tx
levodopa
L-dopa, DA precursor
parkinsons tx
levodopa + carbidopa
DOPA decarboxylase inhibitor.
works in periphery
parkinsons tx
bromocriptine
DA agonist w/ D2 selectivity
parkinson tx
pergolide
DA agonist @ D1 & D2.
Derived from Ergot fungus.
parkinson tx
pramipexole
Non-ergot DA agonist specific for D2 but specfically the D3 subtype.
parkinson tx
selegiline
MAO-B inhibitor
Not non-specific!!!
No inhibition of peripheral NE/5HT metabolism.
Metabolized to amphetamine.
parkinson tx
entacapone
COMT inhibitor
parkinson tx
amantadine
antiviral
MOA??? thought to release DA from nerve terminals
parkinson tx
haloperidol
typical antipsychotic
tourettes tx
clonidine
alpha adrenergic receptor agonist.
tourettes tx
phenytoin
Prolongs state of Na channel inactivation.
DOC for generalized tonic clonic seizures. Also for partial seizures tx
status epilepticus tx
ethotoin
DOC generalized tonic clonic seizures and complex partial seizures tx
valproate
wide spectrum of antiseizure activity.
DOC for atonic & myoclonic seizures or for pts with multiple seizure types.
ABSENCE SEIZURE TX
Also, increases GABA levels by stimulating the synthetic enzyme, glutamic acid decarboxylase and inhibits degradation of GABA also.
carbamazepine
generalized tonic clonic seizures and partial seizures tx.
DOC for all partial seizures.
DOC for tx of trigeminal neuralgia
lamotrigine
wide spectrum of antiseizure activity.
Effective in tx of partial, generalized, and absence seizures.
zonisamide
wide spectrum of antiseizure activity.
ABSENCE SEIZURES tx.
Oligohydrosis(low sweat production) & hyperthermia in pediatric pts.
ethosuximide
DOC for absence seizures(T currents indicative of).
phenobarbital
barbiturate
Enhances GABA-mediated increase in Cl- conductance.
generalized tonic clonic seizures and partial seizures tx
diazepam
BZ
status epilepticus tx
clonazepam
BZ
effective in tx of absence seizures & myoclonic seizures.
infantile spasms tx
gabapentin
promotes release of GABA via an unknown mechanism.
generalized tonic clonic seizures and partial seizures tx.
RENAL EXCRETION.
effective for postherpetic neuralgia.
Drugs for Status Epilepticus?
Phenytoin
Diazepam
Drugs for Absence seziures?
ethosuximide DOC
valproate
lamotriine
zonisamide
clonazepam
amphetamine
anorexiants
narcolepsy tx.
-Indirect acting sympathomimetics. They act to release catecholamines from their stores and to prevent their reuptake.
Schedule II
dextroamphetamine
PSYCHOMOTOR STIMULANTS
ADHD tx
phentermine
Amphetamine derivative
anorexiants
schedule IV
sibutramine
anorexiants.
inhibitors of monoamine(NE, 5HT, DA) reuptake.
schedule IV
methylphenidate
PSYCHOMOTOR STIMULANTS.
ADHD tx
narcolepsy tx
-drugs release NE and DA from neurons and block the reuptake back into the neuron.
Schedule II drug
atomoxetine
Selective NE Reuptake inhibitor
ADHD tx
DO NOT GIVE WITH MAOI!!!
modafinil
narcolepsy tx
Schedule IV drug
theophylline
inhibition of phosphodiesterases => increasing intracellular cAMP.
neonatal apnea syndrome tx
caffeine
inhibition of phosphodiesterases => increasing intracellular cAMP.
neonatal apnea syndrome tx
ethanol?
Only alcohol used clinically
toxic metabolite => aldehyde
methanol?
wood alcohol, poisonous.
toxic metabolite => formic acid
Ethylene Glycol?
antifreeze, poisonous
toxic metabolite => oxalic acid
disulfiram?
aversive deterrent to etOH ingestion
botulinum toxin
NMJ Muscle relaxant.
Presynaptic.
blocks vesicular release of ACh. It cleaves proteins involved in exocytosis of synaptic vesicles w/ ACh
(cis)atracurium
NMJ Muscle relaxant.
Non depolarizing competitive agent

purified form of one isomer of atracurium
vecuronium
NMJ Muscle relaxant.
Non depolarizing competitive agent which is a newer "uroniums"
succinylcholine
NMJ Muscle relaxant.
Depolarizing non competitive agent
diazepam
CNS Muscle Relaxant.
BZ which incr GABA mediated inhibitory synaptic transmission to decr spinal interneuronal signaling.
baclofen?
CNS Muscle Relaxant.
agonist at GABA-B receptor but this action in treatment is questionable.
Reduces the release of glut from spinal neuronal circuits.
dantrolene
Skeletal muscle relaxant.
Peripheral acting, direct effect on the excitation-contraction coupling mechanisms(not at NMJ)
procaine
first synthetic local anesthetic; an Ester.

Hydrolyzed by pseudocholinesterase => gives procaine short half-life.
lidocaine
First amide local anesthetic.

metabolized in liver
Aspirin
NSAID.
decreases prostaglandin(PG) synthesis via inhibition of the enzymes COX I & II at central and peripheral sites.
ibuprofen
NSAID.
decreases prostaglandin(PG) synthesis via inhibition of the enzymes COX I & II at central and peripheral sites.
ketorolac
Inhibition of COX I and II PG synthesis => analgesic, antipyretic and anti-inflammatory actions. Analgesic effect is more potent than antipyretic or anti-inflammatory effects. USE FOR ACUTE PAIN
acetaminophen
analgesic and antipyretic actions but lacks anti inflammatory properties(probably due to peroxide concentrations found at inflammatory sites which inactivate the drug).
morphine
narcotic analgesic.
agonist at mu, kappa, & delta
fentanyl
narcotic analgesic.
agonist at mu.
methadone
narcotic analgesic.
agonist at mu
butorphanol
narcotic analgesic.
partial agonist at mu.
nalbuphine
narcotic analgesic.
partial agonist at mu.
buprenorphine
narcotic analgesic.
partial agonist at mu.
codeine
narcotic analgesic.
-Codine demonstrates good oral:parenteral potency ratios due to structural protection from conjugation.
naloxone
Full narcotic antagonist.
antagonist at mu, kappa, and delta. given via IV.
naltrexone
Pure narcotic antagonist
longer acting and taken p.o.
sevoflurane
General inhalational anesthetic.
Sevoflurane
blood/gas=0.65
oil/gas=50
MAC=2
desflurane
General inhalational anesthetic.
Desflurane
blood/gas=0.45
oil/gas=20
MAC=6
nitrous oxide (analgesic)
General inhalational anesthetic(analgesic component).
-a potent inhalational analgesic agent.
-Used in combo w/ other anesthetic agents, it's inadequate alone.
midazolam
General IV anesthetic.
-a BZ that reduces anxiety and sedates the patient(enhances GABA chloride flow but doesn't produce analgesia.)
propofol
General IV anesthetic.
increases inhibitory synaptic transmission via facilitation of GABA receptor .
-doesn't provide analgesia
etomidate
General IV anesthetic.
-increase inhibitory synaptic transmission via GABA receptor. Doesn't reduce excitatory transmitter release.
ketamine
General IV anesthetic.
Dissociative anesthetic(cataleptic trance)
-noncompetitive antagonist of NMDA glut receptors. Decreases excitatory synaptic transmission by reducing synaptic Ca++ channel conduction.