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7 Cards in this Set
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- Back
- 3rd side (hint)
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Transmissible
Spongiform Encephalopathies (Prion diseases) |
PrP
------------------ a-Helix / random coil >>>> b-pleated sheet / Proteinase K-resistant |
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Alzheimer Disease
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APP
------------------ a-Helix / random coil >>>> b-pleated sheet / amyloid |
memory issues, short term
cognition loss of orientation, confusion |
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Tauopathies
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Tau
------------------ 3 and 4 repeat isoforms >>>> Hyperphosphorylated aggregated protein |
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Parkinson Disease
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a-Synuclein
------------------ Raddom coil, repeats >>>> Aggregated/ Lewy bodies |
Resting tremor, bradykinesia, muscle rigidity
fluctuating consciousness, visual hallucinations |
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Multiple system atrophy
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a-Synuclein
------------------ Raddom coil, repeats >>>> Aggregated, Glial cytoplasmic inclusions |
parkinsonism,
cerebellar and pyramidal signs, and autonomic dysfunction. |
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Huntington Disease
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Huntington
------------------ Trinucleotide repeats >>>> Insoluble aggregates |
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Spinocerebellar
ataxias |
Ataxins
------------------ Trinucleotide repeats >>>> Insoluble aggregates |
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