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13 Cards in this Set

  • Front
  • Back
Environmental Causes of Alzheimers
Elevated levels of:
mercury, aluminum, BMAA
Environmental Causes of Parkinson's Disease
MPTP which leads to production of MPP+
Oxidative Stress in Parkinson's
High iron levels in SN
Peroxide produced by DA metabolism
depletion of glutathione
Cardinal features of Parkinson's
Bradykinesia
Muscle Rigidity
Tremors
Stooped Posture
Cognitive Defects
Basal Ganglia & Parkinson's
Decreased levels of DA lead to decreased stimulation of D1 pathway and decreased stimulation of D2 pathway.
Parkinson's Treatments
L-Dopa
Dopamine Agonists
MAO Inhibitors
COMT Inhibitors
Muscarinic Antagonists
Amantadine (shuts down stimulation by DA)
Levodopa Clinicial Efficacy
Effective in reducing all symptoms of Parkinson's, especially bradykinesia
1/3 respond very well
1/3 show some improvement
1/3 can't tolerate/show no improvement
Levodopa Periphery Adverse Effects
GI Effects
anorexia, vomitting, nausea

CV
cardiac arrhythmias
Levodopa Central Adverse Effects
-Behavioral/Cognitive
Depression, anxiety, insomnia, confusion
-Movement
-Withdrawl
-Wearing-off Syndrome
-On-Off Syndrome
Levodopa Interactions
MAO A Inhibitors
Tricyclic Antidepressants
Pyrixoine (B6)
Additional Treatments for Parkinson's
Dopamine Agonists
MAO Inhibitors
COMT Inhibitors
Muscarinic Antagonists
Amantadine

REGARDLESS OF TX - DISEASE CONTINUES TO PROGRESS!!
Huntington's Disease
Loss of neurons in the striatum
Chorea, Cognitive Impairments
Alzheimer's Disease Treatment
Augment cholinergic function of the brain
-acetylcholinesterase inhibitors