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13 Cards in this Set
- Front
- Back
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How do benzodiazepines effect GABBA receptors?
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-they inc GABBA binding to GABBAa receptors
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Glycine
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-inhibitory NT in the spinal cord
-opens Cl- channels |
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Glutamate
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-main excitatory NT
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Neurosecretion
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-when a specialized neuron releases a modulatory peptide directly into the bloodstream
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How are anterior pituitary hormones regulated?
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-hypothalamic neurons emit releasing factors into the portal system where they control release of ant pit hormones
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Substance P
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-involved in pain modulation
-mostly in spinal cord, trigeminal nerve nucleus and substantia nigra |
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Methionine-enkaphalin
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-inhibits the release of substance P from primary sensory afferents
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What are the major functions of the opioid receptors?
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-dec adenylate cyclase
-inc hyperpolarization -dec Ca2+ influx |
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Cause of Parkinsons
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-loss of DA in the nigral/striatal system
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Cause of Schizophrenia
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-overactivity of DA in the mesolimbic and mesocortical systems
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Cause of Alzheimers
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-loss of cholinergic cells of the nucleus basalis
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Cause of Huntingtons
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-loss of GABAergic and cholinergic cells of the striatum
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Cause of Myasthenia gravis
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-autoimmune response directed against the ACh receptor in the NMJ
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