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13 Cards in this Set

  • Front
  • Back
How do benzodiazepines effect GABBA receptors?
-they inc GABBA binding to GABBAa receptors
-inhibitory NT in the spinal cord
-opens Cl- channels
-main excitatory NT
-when a specialized neuron releases a modulatory peptide directly into the bloodstream
How are anterior pituitary hormones regulated?
-hypothalamic neurons emit releasing factors into the portal system where they control release of ant pit hormones
Substance P
-involved in pain modulation
-mostly in spinal cord, trigeminal nerve nucleus and substantia nigra
-inhibits the release of substance P from primary sensory afferents
What are the major functions of the opioid receptors?
-dec adenylate cyclase
-inc hyperpolarization
-dec Ca2+ influx
Cause of Parkinsons
-loss of DA in the nigral/striatal system
Cause of Schizophrenia
-overactivity of DA in the mesolimbic and mesocortical systems
Cause of Alzheimers
-loss of cholinergic cells of the nucleus basalis
Cause of Huntingtons
-loss of GABAergic and cholinergic cells of the striatum
Cause of Myasthenia gravis
-autoimmune response directed against the ACh receptor in the NMJ