Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
7 Cards in this Set
- Front
- Back
|
What disease is this paper over?
|
Parkinson's
|
|
|
What question are they asking?
|
Why does DBS work and why doesn't it always work?
|
|
|
How did they induce Parkinson's in rats?
|
6-OHDA + amphetamines
|
|
|
Method?
|
Using optogenetics to see what DBS is doing
|
|
|
Halorhodopsin?
|
Cl- pump --> hyperpolarization
|
|
|
Is DBS modifying glia?
|
Ca++, ChR2, phenotype of rat doesn't change, glia not involved
|
|
|
Afferent fibers?
|
figure 6 - deliver light to M1 cortex - conclude that this is area of cortex involved w/ DBS - altering afferent fibers
|
