Neurobiology 2

Front 1

COX-2

Back 1

upregs prostoglandin and uncoupling protein 1

overexpression created brown fat

Front 2

prostaglandin

Back 2

induces dendritic spine growth in POA, masculinization, upregged by estradiol

Front 3

Indomethacin and aspirin

Back 3

block COX-2, can feminize males

Front 4

dnmt

Back 4

methylates in POA preventing masculinization via dendritic arborization

higher in females

reduced by estradiol

Front 5

dnmt3

Back 5

maintenance

Front 6

dnmt alpha

Back 6

de novo

Front 7

zeb

Back 7

inhibits dnmt

Front 8

male aggression

Back 8

due to y, not sry

Front 9

bird sex

Back 9

Birds have ZW system with females heteroIn birds, male is default sex and females must be demasculinized by aromatase’s early actionWhile testosterone barely masculinizes females during adulthood, early estradiol demasculinizes males a lot

Front 10

hvc

Back 10

higher vocal control center

Front 11

ra

Back 11

linked to innervation of vocal control

Front 12

Fadrazole

Back 12

blocks aromatase

Front 13

tamoxifan

Back 13

blocks ER

Front 14

dhtp

Back 14

defeminizes presentation/solicitation but not receptiveness in primates

Front 15

Congenital adrenal hyperplasia

Back 15

(high prenatal test) in humans masculinizes toy choice and peer selection as well as makes them somewhat more gay

Front 16

Cloacal exstrophy

Back 16

often results in “ftm” people when they are reassigned at birth for surgical reasons, indicating the early action of testosterone on gender bc they are then castrated

Front 17

Peg3

Back 17

should be paternally imprinted and when it’s not they’re less maternal Bc mutation impairs development of oxytocin neurons

Front 18

VMH lesion

Back 18

fat

Front 19

LH lesion

Back 19

starved

Front 20

Stimming Vgat in Bnst

Back 20

induces feeding

Front 21

Parabiosis

Back 21

siamese twin experiments

Front 22

MTII

Back 22

melanocortin agonist

Front 23

SCN neurotransmitter

Back 23

glutamate

Front 24

prokineticin

Back 24

paracrine signal from SCN?

Front 25

5-ht, D-fen, nicotine

Back 25

activate pomc

Front 26

Ghrelin

Back 26

acts upstream of NPY and AGRP, upregs them

Front 27

PYY

Back 27

inhibits NPY neurons

Front 28

FXR

Back 28

KO attenuates benefits of gastric bypass

Front 29

B receptors

Back 29

KO of ____ causes failure of body temp maintenance and much lower metabolismAgonists of ____ cause high metabolism and lots of heat___ involved in lipolysis

Front 30

uncoupling protein

Back 30

Overexpression of ____ causes conversion to brown fat and lower body heat and more heat

Front 31

Framingham Heart Study

Back 31

big heart data set

Front 32

connexin

Back 32

KO causes failure to synchronize SCN neurons

Front 33

casein kinase proteins

Back 33

Tau determined by ___ that phosphorylate and build up

Front 34

Bmal and clock

Back 34

upreg ebox

Front 35

cry and per

Back 35

downreg e box

Front 36

orx

Back 36

orexigenic peptide

Front 37

Intrinsically photosensitive retinal ganglion cells

Back 37

innervate the SCN, they’re sensitive to blue light and respond to low levels, use melanopsin

Front 38

per1

Back 38

KO abolishes shift due to light pulse

Front 39

NMDA receptor antagonist

Back 39

attenuates phase shift

Front 40

vasopressin receptor

Back 40

KO creates seamless readjustment to new timezone by severing connections to peripheral slave oscillators

Front 41

Subfornical organ Nos1 neurons

Back 41

thirst