Neuro1020_Exam 2_Molecules

Front 1

synapsin I

Back 1

attach vesicles to actin filaments under low calcium conditions

Front 2

actin

Back 2

structual protein involved in vesicle clustering and maintain rigidity in hair cells

Front 3

CAM

Back 3

calcium/calmodulin dependent kinase, involved in vesicle clustering and nitric oxide pathways

Front 4

Piccolo, bassoon, and RIM

Back 4

scaffolding proteins within the active zone involved in vesicle targeting

Front 5

Rab3

Back 5

actively bring vesicles closer to the presynaptic membrane, GTP bound

Front 6

VAMP

Back 6

vSNARE protein which interacts within SNAP25 mediated by synaptotagmin

Front 7

Synaptobrevin

Back 7

vSNARE protein

Front 8

Syntaxin

Back 8

tSNARE protein

Front 9

SNAP25

Back 9

tSNARE protein which interacts wtih VAMP (mediated by synaptotagmin)

Front 10

Synaptotagmin

Back 10

causes interaction between VAMP and SNAP25 causing vesicle docking and fusion

Front 11

NSF/SNAP

Back 11

bind to SNARE complex causing disassociation requiring ATP

Front 12

AP-2

Back 12

binds to synaptotagmin creating a scaffolding necessary vesicle exocytosis in endosomal recycling

Front 13

Clathrin

Back 13

binds to AP-2 scaffolding

Front 14

Dyamin

Back 14

pinches off the vesicle after the binding of clathrin and AP2

Front 15

Nicotonic AChR

Back 15

ionotropic, permeable to sodium and potassium

Front 16

Muscarinic AChR

Back 16

metabotropic, permeable to potassium ion

Front 17

GRK

Back 17

phosphorylates c-terminus of g-protein coupled recptors preventing signal propagation

Front 18

RGS

Back 18

facilitates hydrolyzation of GTP to GDP inactivating g-proteins

Front 19

Arrestin

Back 19

binds to phosphorylated c-terminus of g-protein couple receptors

Front 20

Arc

Back 20

used to demonstrate targeting of proteins in cells

Front 21

Tau

Back 21

axon associated protein

Front 22

MAP2

Back 22

dendrite associated protein

Front 23

NGF/BGNF/NT3/NT4

Back 23

neurotrophins, tyrosineRKinases that activate downstream signaling cascades via phosphorylation

Front 24

Touch receptor process

Back 24

specialize mictrotubule that provide an intracellular tethering point

Front 25

MEC4

Back 25

mutation causing loss of stretch gating mechanism

Front 26

MEC10

Back 26

some amino acid changes cause channel leakiness (gain of function)

Front 27

Mechanosensory channel subunits

Back 27

MEC4 and MEC10

Front 28

Mechanosensory accessory proteins

Back 28

MEC2 and MEC6

Front 29

Tubulins

Back 29

MEC7 and MEC12

Front 30

Collagen

Back 30

MEC5

Front 31

Extracellular proteins

Back 31

MEC1 and MEC9

Front 32

CEP neurons

Back 32

respond rapidly to touch on the nose of c. elegans, not sodium dependent with Vrev=0

Front 33

TRP channels

Back 33

used by CEP neurons, respond to capsaicin, menthol, mustard oil, temp and some force

Front 34

TRP4

Back 34

mechanosensory channel for CEP neurons

Front 35

Mechanosensory structures in the ear

Back 35

ossicles and steriocilia

Front 36

Utricle and sacculus

Back 36

detect motion of the head by deflection of the kinocilia

Front 37

Otoliths

Back 37

move at different rates than hair cell projections

Front 38

Cupula

Back 38

located in the semicircular canal?
Contain hair cell cell bundles, involved in proprioception

Front 39

Benign paroxysmal position vertigo

Back 39

otoliths get into places with the semicircular canal causing false movement detection