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105 Cards in this Set

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Atypical Parkinsonism
The most important Clinical evidence?

Poor Response to L Dopa

Absent Tremor only in 30%

Anticoagulation in Pt with Stoke?
a Cryptogenic or Small Vessel


b -AF


c +Recurrence, MI, Vascular (+PAD)


d Vascular stent or Prev. MI


e +AF


a Aspirin or Warfarin


b Aspirin 81mg
C Clopidorgrel or Aspirin+Dipyridamole
d Combination
e
warfarin

Progressive Gait impairment (Lower Body Parkinsonism)+ Urinary incontinence :
NI??

MRI Brain: Expanded Lat & 3rd Ventricle

Normal Pressure Hydrocephalus
+ Dec. Cognitive function → Dementia
Mx by serial LP

Mirgraine Rx and Pregnancy ?

Paracetol , Ondansteron & Placil are Safe

Triptans class C
Dont Use until all B used , Naproxen B but C in 3rd Trimester

Post Concussion & Post Traumatic Stress disorders?
How to differntiate?

PTSD : Anxiety disorder


Persistent memory about the event Cognitive, Emotional and memory defects + Headaches, Sleep distrub or which occur in Nightmaires, and Accident Remembering

PCS Symptom Resemble CFS:
Headache Dizziness Fatigue Irritability Sleep problems Concentrationproblems-Memoryproblems


stress/emotion/alcohol-,anxiety, or depression-


Changes in personality-


Apathy

Stenting indication of ICA stenosis?

Recurrent Symptoms


Evidence of Continuing Ischemia

Post Stroke mx? whats most important?

Early rehabilitation
+ Manage complications

How to Differntiate btw Malignant Hypert & NMS ?
Remember the TRIAD

NMS a/w ( Haloperidol) or any antipsychotic medication
+ TRIAD of
(Hyperthermia &Automomic Dysf.)+ (Extrapyramidal signs: Rigidity or Dystonia(Parkinsonsim+
Elevated Muscle enz.) and Delirium
MH: Inherited Anasthetics more+ Acute Kidney injury (RMLysis)

NMS:
Mx: Stop Medication + Supportive (Fluids) / Bromocriptine & Dantrolene play the Rule
DDX: Serotonin Syndrome
( Confusion, Myoclonus , Diaphoresis) triggered by Overdose due to SSRI or MAOI

if pt indicated for rtPA be you search for?

Contraindicatiions


Natalizumab JC SE?

Increased Risk of JC virus inf.:
PML

نتالي زبة تكول jc مو ماب

Dopamin Agonist (Ropinirole) Side Effects ?

Punding



Compulsive disorder , doing complex repetitive activities whitout Purposes , Rx by Dec. the dose. ( other behavioral : Internet use , Shopping , Gambling )

Arnold Chiari malformation , which type of Nystagmus?

Down beat nystagmus +- Syrinx


4 types


Headaches aggravated by Valsalva maneuvers, such as yawning, laughing, crying, coughing, sneezing or straining, bending over, or getting up suddenly[26]



Tinnitus (ringing in the ears)



Lhermitte's sign


Vertigo (dizziness)


Nausea


Nystagmus (irregular eye movements; typically, so-called "downbeat nystagmus")



Facial pain


Muscle weakness


Impaired gag reflex


Difficulty swallowing


Restless leg syndrome


Sleep apnea


Sleep disorders[27]


Dysphagia (difficulty swallowing)[28]


Impaired coordination



Severe cases may develop all the symptoms and signs of a bulbar palsy


Paralysis due to pressure at the cervico-medullary junction may progress in a so-called "clockwise" fashion, affecting the right arm, then the right leg, then the left leg, and finally the left arm; or the opposite way around.


Increased intracranial pressure


Pupillary dilation



Dysautonomia: tachycardia (rapid heart), syncope (fainting), polydipsia (extreme thirst), chronic fatigue [29]



The blockage of cerebrospinal fluid (CSF) flow may also cause a syrinx to form, eventually leading to syringomyelia. Central cord symptoms such as hand weakness, dissociated sensory loss, and, in severe cases, paralysis may occur.[30]

+- hydrocephalus can occur due to the narrowing at the foramen magnum

A 72 year old man presents to A and E with a funny turn. he has a history of hypertension. On examination he is found to have grade 3/5 and reduced sensation in his right arm and leg. He is also found to have reduced sensation on the left side of his face and there is evidence of a Horners Syndrome. He is ataxic. Where is the lesion likely to be?

Lateral Medullary Syndrome

Brain stem affected

Give Example of MAOI?
and other or COMPT?

Seligiline
Entecapone

Entecapone : Adjunct

Tricks in Parkinson Mx?
A Main Drug
B Drug induced P
C Adjunct to Levo Dopa
D Elderly
E

A Ropinirol
B Antimuscarnic: Procyclidine
C COMT I : Entecapone
D Levodopa
E

Levodopa SE:
dyskinesia(involuntary writhing movements), 'on-off' effect, dry mouth, anorexia,palpitations, postural hypotension,psychosis

Medical Mx of Restless leg syndorme?

Ropinirole

رجل مشدودة بحبل

spontaneous, continuous lower limb movements that may beassociated with paraesthesia

or


uncontrollable urge to move legs

or Symptoms are worse at rest· paraesthesias e.g. 'crawling' or 'throbbing' sensations ?

Restless leg syndrome

Rx with Ropinirole

with Axillary and groin freckles DX?

with Axillary and groin freckles
DX?

NF1: Ch 17 ,1 in 4000 mild >>


which may be evident at birth and nearly always by the time the child is 10 years old, may include light brown spots on the skin ("cafe-au-lait" spots), two or more growths on the iris of the eye, a tumor on the optic nerve, a larger than normal head circumference, and abnormal development of the spine, a skull bone, or the tibia.

Lisch Nodule

Lisch Nodule

Ramsay Hunt Syndrome?

Vesicular rash of the ear or mouth (as many as 80% of cases)


The rash might precede the onset of facial paresis/palsy (involvement of the seventh cranial nerve [CN VII])


Ipsilateral lower motor neuron facial paresis/palsy (CN VII)


Vertigo and ipsilateral hearing loss (CN VII)


Tinnitus


Otalgia


Headaches


Dysarthria


Gait ataxia


Fever


Cervical adenopathy




Facial weakness usually reaches maximum severity by 1 week after the onset of symptoms.

Facial weakness usually reaches maximum severity by 1 week after the onset of symptoms.

Forgotten Feature in LEMS?

3 Forgotten causes of of Facial Pulsy?

How to dif bw Hunting and AD?

Css of Resless leg syndrome?

Tips of Fredritchs ataxia?

Myotonic Dystrophy Tips?

???

PML? CAUSE And Patho?

Natalizumab play a cause to jc

Shy Drager R5?

????

TRIAD of IIH?

اتذكر ال ايييجة الي حاطة ايدهة علة راسهة

Causes of Dactylitis?

Presentation of Acoustic Neuroma?

HSV Encephalitis? R5



Not Meningitis

Visual opacities? 6 types

Optic Defect localizing signs?

R5 MERRF?

Site of Huntington Defect?

Paraneoplastics Neuro Manifest?

Copper def 3 F and likely cause?

S2 splitting Conditions

Where memory sight in Brain?

Allodynia a/w?

Brands of Antidepressants?

Chondrocalcinosis X Ray ¿

R5 of Tardive dyskinesia?

5 As of Alzehiemer D?

>> of Dementias?

How to diff CDH?

<> 4h

Cogn. Imp Drugs?

BISAP?

Be sure from net

Css of Cerebral Hemorrhage?

Rule of Dexamerhazone in Meningitis?

Just pneumococcal one


1 dose before ABs


And Continue *4 for 4 days

Primipixole SE?

→ Sudden Sleep, Hallucination

When u say this Imfarct is lacunar?

Small Vessel: < 0.5 mm are the lenticulostriates, the brainstem penetrating and the thalamogeniculate.



Common Css, of ICH acc to Age?

< 45 y: Drug Abuse ( Cocaine and amphetamin) and AV Malformation


>55 y HT and amyloid Angiopathy

Excessive Alcohol Also

2 presentation of Berry Aneurysm?

1 Sever Headache


2 CN 3 Pulsy with ipsilateral Pupillary dilatation and ?

Xanthocromia: conversion of Hemoglobin to Billirubin

Notes on Drugs

Drugs Cause Perph. Neurop: NM VIA TCA



Amiodarone→للدوة الوحيد الي يسوي → Demylination



Triptans→ لاتنطي حتة لو rf لل ischemia وينطه at onset of Headache مو Aura





Amytriptyline: امي تبتليني البولة محصورة مالتهة



Citalopram يطير الشهوة عليك بس ما يخصيك عكس ال opiates



بالبال بالخاطر ال buscopan كونترا انديكيتد بال MS؟؟؟

4 components of Stroke?

Aphasia (Language not muscle)


Weakness


Numbness


Ophthalmic

You cant say Apraxia in?


You cant say snsory or cerebellar in?

Motor abn


Unconsiousness (Motor may be preserved : respond to pain)

>> pres in Conversion disorder?

Blindness

Old age + dysphagia 1st slowly to solids then rapid liquids


with Depression or Postural Inst?

Parkinson

Mycosis Fungoides?

Albert Bazin $

Contents of Language?

Forgotten C? Cluster of Horns


2 TT?

Pentad of Wernick's En. ? 2 of 4


Causes?

Neuro Paraneoplastic Abs?

3 Drugs © Parkinson?

EMG changes in MND?


يعني هي العضلة مابيهة شي بس صوجة هو ماعندة طاقة

↓AP ↑Amplitude

What diff Apoplexy from SAH?


3

Hypotention


Hypothyroid


Extraocular Pulsy

Myo Dystrophy Classification?


Cardiac involvement ?

Amaurosis Fugax? ©

NPH 2° to ?

Head Injury


SAH


Meningitis

Reversible


Rx by Shunt

Exam of Encephalopathy?

Neurological Complication inRenal disease?

Trouble With:Speech control—volume, pitch, articulationWriting and typingOver- or under- sensitivity to light, touch, space, taste, or smells


Dyspraxia Seen in Stage 2 HE

Personal grooming and other self-help activitiesCooking or other household choresDrivingClumsiness

>> inherited Neurological Disorder?

CMT




the initial symptom is foot drop


the it may go to Hands, eye SC and others




Motor and Sensory (Pain Preserved) with Hammer Toe




No Available Rx

Charcot Joint? or



Neuropathic Athropathy


  1. Complication of neuropathy and repeated joint trauma
  2. Progressive degeneration of a weight bearing joint, a process marked by bony destruction, bone resorption, and eventual deformity
  3. History / PE: Decreased pain, proprioception, and temperature perception
  4. Treatment:
    Treat underlying disease
    Mechanical devices (eg. special shoes)
    Decrease further trauma
  5. Associated With:

    Diabetes mellitus
    Perpheral nerve damage
    Syringomyelia
    Spinal cord injury
    Vitamin B12 deficiency
    Tabes dorsalis

Tabes dorsalis?

syphilitic myelopathy (Dorsal Colomn)

Todd Paralysis

Weakness in Upper limb contra lateral to the Side of Seizure

>> cause of temporal lobe epilepsy?

Mesial Temporal Seclerosis


(Hippocambus)

Pelvic Thrusting >> seen in ?

Frontal Lobe Epilepsy


also:


<30s


absent Post Ictal


Sexual Automatism


Eye Deviation CL to the Seizure site


Vocalization (very common)


Contiousness more Preserved


HemiClonic (CL Face arm and leg seizures)


Jacksonian F


Fencing Posture(Flexing the ipsi and relaxing the CL with DEviation of face and Eye to CL)





Pain located on the front of the thigh and shin, further radiates towards the inner ankle, sometimes the medial toe

L4 radiculopathy





Occasionally, failure of the quadriceps muscle and reflex weakness

Sensory loss posterolateral aspect of leg and lateral aspect of foot Weakness in plantar flexion of foot Reduced ankle reflex -n-->"}

L5 radiculopathy




Pain radiates to the side of the thigh and lower leg towards the back of the foot and toes 1-3


All reflexes are preserved

S1 radiculopathy?

Pain radiates to the posterior side of the thigh and lower leg to the ankle side, sometimes on up to the fourth toeGluteal muscles are weakenedDifficulty standing on toes

Causes of 3rd CNP?

Causes


diabetes mellitus


• vasculitis e.g. temporal arteritis, SLE



• false localizing sign* due to uncal herniation through tentorium if raised ICP


posterior communicating artery aneurysm (pupil dilated+Sever Headache)


cavernous sinus thrombosis


• Weber's syndrome: ipsilateral third nerve palsy with contralateral hemiplegia -caused by midbrain strokes


• Berry Aneurysms



• other possible causes: amyloid, multiple sclerosis

DDX of Peripheral or Ring Enhaced lesion?




MAGIC DR


  1. cerebral abscess
  2. tuberculoma
  3. neurocysticercosis
  4. metastasis
  5. glioblastoma multiforme
  6. subacute infarct / haemorrhage / contusion
  7. demyelination (incomplete ring)tumef
  8. active demyelinating lesion (incomplete ring)
  9. radiation
  10. necrosis
  11. postoperative change
  12. lymphoma - in immunocompromised patient

MAGIC DR:


M: metastasis


A: abscess


G: glioblastoma multiforme


I: infarct (subacute phase)


C: contusion


D: demyelinating disease


R: radiation necrosis or resolving haematoma

C5 radiculopathy?

Pain is found along the lateral brachium of the affected side of the arm.


C5 innervated muscle weakness may be found i.e rhomboids, deltoid etc.

C6 radiculopathy?



Pain is found along the lateral antebrachium of the affected arm


C6 innervated muscles are weak i.e forearm pronator and supinators, wrist extensors etc.

C7 radiculopathy?

Pain is found along the middle finger of the affected armC7 innervated muscle weakness is found i.e wrist flexors, finger extensors etc.

contralateralhemiparesis and sensory loss,


lower extremity > upper


· disconnection syndrome (Conducting Aphasia)

Anterior cerebral artery ·

· contralateral hemiparesis and sensory loss, upper extremity > lower


· contralateral hemianopia


· aphasia (Wernicke's)


· gaze abnormalities

Middle cerebral artery

· contralateral hemianopia with macular sparing


· disconnection syndrome

Posterior cerebral artery

· present with either isolated hemiparesis, hemisensory loss or hemiparesis with limb ataxia

Lacunar

· ipsilateral: ataxia, nystagmus, dysphagia, facial numbness, cranial nerve palsy


· contralateral: limb sensory loss

Lateral medulla (posterior inferior cerebellar artery)

· VI nerve: horizontal gaze palsy


· VII nerve


· contralateral hemiparesis

Pontine

· sensory inattention


· apraxias


· astereognosis(tactile agnosia)


· inferior homonymous quadrantanopia


· alexia, acalculia, finger agnosia and right-left disorientation

Parietal lobe lesions

Gerstmann's syndrome (lesion of dominant parietal): alexia, acalculia, finger agnosia and right-left disorientation

· homonymous hemianopia (with macula sparing)


· cortical blindness


· visual agnosia

Occipital lobe lesions

· Wernicke's aphasia


· superior homonymous quadrantanopia


· auditory agnosia


· prosop-agnosia (difficulty recognising faces)

Temporal lobe lesion

· expressive (Broca's) aphasia


· disinhibition (perceptual(hypersexuality, hyperphagia), Motor, and Cognitive) also in TBI


· perseveration ( Difficulty in Switching between ideas or Orders) most Commonly in TBI


· anosmia


· inability to generate a list

Frontal lobes lesions

(Broca's) aphasia: located on the posterior aspect of the frontal lobe, in the inferior frontal gyrus

· midline lesions: gait and truncal ataxia


· hemisphere lesions: intention tremor, past pointing, dysdiadokinesis, nystagmus

Cerebellum lesions

· lefthomonymous hemianopia means?

visual field defect to the left


Lesion of right optic tract

· incongruous defects;

= optic tract lesion

congruous defects =



optic radiation lesion or occipital cortex

what means congrous and in congrous?

A congruous defect simply means complete or symmetrical visual field loss and conversely an incongruous defect is incomplete or asymmetric.

Homonymous hemianopia Presentations? 3

· incongruous defects: lesion of optic tract


· congruous defects: lesion of optic radiation or occipital cortex


· macula sparing: lesion of occipital cortex

macula sparing?

: lesion of occipital cortex

Bitemporal hemianopia



· lesion of optic chiasm




· upper quadrant defect > lower quadrant defect = inferior chiasmal compression, commonly a pituitary tumour




· lower quadrant defect > upper quadrant defect = superior chiasmal compression, commonly a craniopharyngioma