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225 Cards in this Set

  • Front
  • Back
The ear is divided into what 3 parts?
outer ear (air filled)
middle ear (airfilled)
inner ear (fluid filled)
describe the outer ear
funnel-shapped contains pinna (auricle)
and canal (external auditory meatus)
describe the middle ear
contains
1-the ear drum (tympanic membrane)
2-the ossicles (incus, maleus, and stapes)
3- muscles include the tensor typani and the stapedus
what nerves innervate the stapedus?
cranial nerve VII- motor arm of the stapedus reflex and cranial nerve VIII-sensory arm of stapedus reflex
sensation of sound =
sensation of mechanical vibrations (air molecules disturbed vibrate tympanic membrane) ossicles attached to each other help amplify and cochlea becomes excited
define the cochlea
colied, hollow tube of bone extending from the vestibule. 1 end of the stapes attaches to its opening
naturally the cochlea makes a ___ turn but if you uncoil it....
2 3/4 turn but if you uncoil it there are 3 chambers: 1. scala vestibuli, scala media (cochlear duct), 3. scala typani
If you stretch/flatten/uncoil the cochlea, you can see 3 chambers or compartments. What are they?
1. scala vestibuli
2. scala media (cochlear duct)
3. scala tympani
cochlea is divided through most of its length by a membrane partition. What is this partition called?
scala media or cochlear duct (endolymph filled)
what are the 2 fluid filled spaces (scalene) formed by the dividing midline?
scala vestibuli (parilymph filled)
scala tympani (parilymph filled)
what are the two types of fluid in these scalene?
1. perilymph
2. endolymph
explain perilymph. What is it rich in. Where is it located (which scalas?)
within scala vestibuli and scala tympani; rich in sodium (Na+) ions; like intracellular
explain endolymph. What is it rich in. Where is it located (which scalas?)
within scala media, rich in potassium (K+) ions; like extracellular fluid
fluid with scala vestibuli and scala tempani can/cannot mix
can! they are both perilymph
fluid with scala vestibuli and scala media can/cannot mix
cannot! endolymph and perilymph do not mix
what are the small openings through which perilymph travels between scala vestibuli and scala tympani?
heliocotrema
what are the two openings (membranes) that connect the middle ear to the inner ear?
1. oval window
2. rounded window
explain the oval window
where the stapese is atteched to the cochlea, where 1 end of the scala vestibuli ends
explain the rounded window
where one end of the scala tympani ends
oval window leads to scala vestbuli, which leads to what?
helicotrema which leads to scala tympani which leads to rounded window
so, tympanic membrane vibrates --> name the rippling effect next sequence of events in order:
1. ossicles vibrate
2. footplate of stapes rocks 3. vibration transmitted to oval window
4. a wave is sent rippling through the perilymph (toward the helicotrema)
5. wave contiinues in the perilymph of the scala tympani
6. round window bulges out when the wave reaches it (for pressure relief)
what is the organ of corti?
the core component of the cochlea; within scala media; rests on basilar membrane
how does the organ of corti work?
has mechanoreceptors AKA haircells(sensitive to mechanical changes, or vibrations)that convert vibration into electrical action potential
name the 2 types of haircells
inner haircells
outer haircells
how many rows are there of inner haircells versus outer haircells?
1 row of inner
3 rows of outer

(but inner haircells have more innervation)
what nerve innervates haircells
CNVIII innervates both outer and inner haircells--95%! of CN VIII fibers innervate inner hair cells
where are haircells arranged?
in 4 rows along the entire length of the cochlea
what causes sensorineural hearing loss?
a very strong movmeent of the endoly,ph (due to very loud noise) may cause haircells to die
what is the most common kind of hearing impairment
sensorineural
what is one major cause of sensorineural hearing loss
the reduction of the function of the organ of corti
what are sterocillia
haircell microvilli (microvilli means small extensions of the cell's surface)that sit on top of the haircell on the end closest to the endolymph
what are tip links
filametous connections that extend from the tip of each stereocillium to its next tallest neighbor (spring-like)
vibration of the orin of corti causes bending of the _______
stereociilia (they're rigid so they dont bend all the way, but they tilt)
Because of _______, when one stereocillum bends, the one next to it is affected, too
tip links
so in conclusion, what causes vibration of the organ of corti and ultimately bending of the stereocillia
a wave is sent rippling through the perilymph--> causes virbation of basilar membrane (and endolymph in scala media)-->causes vibration of the organ of corti--> causes movement of the haircells
motion of the haircells is converted into_____
electrical signals
Where are ion channels located
at the tip of the tip lnks
If you stretch/flatten/uncoil the cochlea, you can see 3 chambers or compartments. What are they?
1. scala vestibuli
2. scala media (cochlear duct)
3. scala tympani
cochlea is divided through most of its length by a membrane partition. What is this partition called?
scala media or cochlear duct (endolymph filled)
what are the 2 fluid filled spaces (scalene) formed by the dividing midline?
scala vestibuli (parilymph filled)
scala tympani (parilymph filled)
what are the two types of fluid in these scalene?
1. perilymph
2. endolymph
explain perilymph. What is it rich in. Where is it located (which scalas?)
within scala vestibuli and scala tympani; rich in sodium (Na+) ions; like intracellular
explain endolymph. What is it rich in. Where is it located (which scalas?)
within scala media, rich in potassium (K+) ions; like extracellular fluid
fluid with scala vestibuli and scala tempani can/cannot mix
can! they are both perilymph
fluid with scala vestibuli and scala media can/cannot mix
cannot! endolymph and perilymph do not mix
what are the small openings through which perilymph travels between scala vestibuli and scala tympani?
heliocotrema
what are the two openings (membranes) that connect the middle ear to the inner ear?
1. oval window
2. rounded window
explain the oval window
where the stapese is atteched to the cochlea, where 1 end of the scala vestibuli ends
explain the rounded window
where one end of the scala tympani ends
oval window leads to scala vestbuli, which leads to what?
helicotrema which leads to scala tympani which leads to rounded window
so, tympanic membrane vibrates --> name the rippling effect next sequence of events in order:
1. ossicles vibrate
2. footplate of stapes rocks 3. vibration transmitted to oval window
4. a wave is sent rippling through the perilymph (toward the helicotrema)
5. wave contiinues in the perilymph of the scala tympani
6. round window bulges out when the wave reaches it (for pressure relief)
what is the organ of corti?
the core component of the cochlea; within scala media; rests on basilar membrane
what are the 2 types of hair cells in the cochlea?
1.- inner hair cells (1 row)
2- outer hair cells (3 rows)
where are the rows of haircells arranged?
along the entire length of the cochlea
what nerve innervate inner and outer hair cells?
cranial nerve VIII
95% of cranial nerve VIII fibers innervate what?
inner cells
what can cause sensorineural hearing loss
a very strong movement of the endolymph due to very loud noise-- damages the hair cells
what is the most common kind of hearing impairment
sensorineural
once haircells are damaged, do they regenerate?
nope
hair cell microvilli, which are small extensions of the cell's surface, they sit on top of the haircell, on the end of the cell thats closest to the endolymph
stereocillia
filamenteous connections that extend from the tip of each stereocillium to its next tallest neighbor
tip links
vibration of the structure __________causes bending of what?
vibration of the structure, the organ of corti, causes bending og the stereocillia (they are rigid, so they dont bend over all the way, but they tilt)
Because of _________, when one stereocillium bends, the one next to it is affected too
tip links
so what causes vibration of the organ of corti and ultimately hearing?
1. a rippling wave is sent through the perilymph
2. causes vibration of basilar bembrane (and endolymph in the scala media)
3. causes vibration of the organ of corti
4. causes movement of haircells (bending of stereocillia)
5. motion of hair cells is converted into electrical signals
so motion of the hair cells is converted into electrical signals.... where and how?
at the tips of the tip links there are channels that open when stereocilia bend; when they open K+ goes in, and the haircells become depolarized, then calcium channels open and calcium goes in, the the haircells release neurotransmitters and the neurotransmitters bind with CN VIII; CN VIII fires!
what does the organ of corti rest on?
the basilar membrane
are haircells specialized?
yes, different receptor haircells along the basilar membrane respond best to sounds of different frequencies
what do hair cells convert vibration into then?
electrical action potential
which end of the organ of corti is near the oval window
basal end
which end of organ of corti is near the apex of the cochlea
apical end
where are hair cells more sensitive to higher frequencies
basal end
where are hair cells more sensitive to lower frequencies
apical end
what is the tonotopic map analogous to
somatotopic map of the sensory pathway
whose dendrites make synaptic contact with the base of the hair cells
spiral ganglion cells
spinal ganglion cell axons make up what?
spinal ganglion cell axons bundle together to form the auditory portion of CN VIII
which brainstem nuclei are involved in the auditory system?
1) cochlear nucleus (in caudal pons)
2) superior olivary nucleus (in caudal pons)
3) inferior colliculus (in caudal pons)
which thalamic nuclei are involved in the auditory system
medial geniculate nucleus (MGN)
so haircells transmit electrical signals to what? And then where is the first synapse
haircells transmit electrical signals to cranial nerve VIII and the first synapse is at the cochlear nucleus in the caudal pons of the brainstem
after the tranmitted signal synapses in the cochlear nucleus, do the fibers of CN VIII cross the midline?
Well MOST of them do, but some fibers ascend ipsilaterally from the cochlear nucleus and do not cross the midline (there are much fewer of these fibers)
the auditory pathway divides into two branches. What are they?
the ventral branch and the dorsal branch
if the signal chooses the ventral branch, where will the second synapse be?
superior olivary nucleus (brainstem)
if the signal chooses the ventral branch, where will the third synapse be?
inferior colliculus
if the signal follows the dorsal branch, where will the second synapse (after the cochlear nucleus) be?
directly at the inferior colliculous
after they went their separate ways, both the ventral and the dorsal branch then synapse at the _______ and the ______
medial geniculate nucleus (thalamus) and finally in the auditory cortex.
what are the white fibers of the VENTRAL branch that ascend from the cochlear nucleus, cross the midline, and then ascend to the superior olivary nucleus called?
trapezoid body
what are the white fibers, in both the ventral and the dorsal branches, that ascend from the trapezoid body (superior olivary nucleus) to the inferior colliculous called?
lateral lemniscus-- dorsal and ventral branches dont actually join tracts but both tracts ascending together are known as lateral lemniscus
what are white fibers that ascend from the inferior colliculous to the MGN
inferior brachium
what is the anatomical term for the primary auditory cortex
transverse temporal gyrus (Heschl's gyrus)
where does information travel from the transverese temporal gyrus/primary auditory cortex?
association auditory cortices (Wernicke's area)
Most fibers ascend contralaterally from the cochlear nucleus true or false
true
some fibers ascend ipsillaterally from the cochlear nucleus and they follow the same path of the fibers that did cross true or false
true
less fibers ascend ipsillaterally true or false
true
the first synapse of CN VIII is always on the ipsilateral side of cochlear nuclues true or false
true-- the first synapse is before anything crosses the midline
after the first synapse the fibers split into 3 branches true or false
false-- the fibers split into 2 branches, the ventral and dorsal branch, most then cross the midline and travel contralaterally while some ascend ipsillaterally while still following the same path.
what is the first point where information from both ears converges from
superior olivary nucleus
what structure, then is important for sound localization
superior olivary nucleus-- 1st point where information from both ears converges, requires us to interpret auditory informatio from both ears
if cranial nerve VIII is lesioned what would follow
total ipsilateral deafness because no information is going to the brainstem from that side
if lesion is at the cochlear nucleus what would follow
still total ipsilateral deafness (first synapse)
if the lesion is at 1 side's trapezoid body what would follow
you wont observe total deafnessin the contralateral ear because there are ipsilateral fibers from the other side that can compensate; you'll observe hearing loss in both ears with more on the contralateral side than the ipsilateral side
rememeber disturbance in fluid from oval window to round window but sometimes there's a backward movement of the fluid through the chambers from round window to oval window too. why?
oval window is pushed out causes ossicles to vibrate, causes tympanic membrane to vibrate
when theres a backward movement of fluid from the round window to the oval window this is called
otoaccoustic emmisions (OAEs-- ringing in the ears)
so OAEs =
sound produced by vibrations of tympanic membrane
the cochlea doesnt only retrive sound, it generates it too! true or false
true (OAEs)
what is the main function of the vestibular branch of Cranial nerve VIII
process information involving gravity, rotations, acceleration
why are the OAes often used as a measure of inner ear health?
after the inner ear has been damaged OAEs dissapear.
Simple, non-invasive test for hearing impairment especially good for infants who cant respond verbally also good for children who are too young to cooprtate in conventioal hearing tests
how are OAEs recorded
will a microphone in the ear canal
hair cell receptors of CN VIII are responsible for direct ________, acceleration located in the ______ _, _____, and _____.
direct gravitational pull, acceleration, located in the utricle, saccule, and semicircular canals.
where are the hair cell receptors of the vestibular system located?
hair cell receptors are enclosed in the utricle, saccule, and semicircular canals; haircells sit on a small swelling at the base called the ampula
what is the vestibule
area where semicircular canals converge, contains the utricle and the sacule
name 3 semicircular canals
horizontal, posterior, and anterior
the 3 semicircular canals are filled with what
endolymph
what does the ampula contain
crista
what is crista
ridge of epithelial tissue convered by sensory haircells
what is the gelatinous mass that covers the crista
cingual
what does the motion of the endolymph tell us
where we're going! each canal deals with movement (up/down, side to side, tilting from one another)
what is whole canal called
labrynth
hair cells are activated by the movements of what-- explain
endolymph
movement stilmulates hair cells, endolymph lags behind because of inertia when endolymph catches up, stimulation ceases; once movement stops, endolymph continue to move for a short time therefore movement is effected by haircells
hair cells are polarized, what does this mean functionally
if haircells are pushed one way they become excited, if they are pushed the other way, they become inhibited
haircells are most sensitve to what type of acceleration?
angular accelaration (shake head no)
are there cirstae in the untricle and saccule?
nope
the utricle and sacule each have a patch of hair cells. There are called____
macula
utricular macula is what directional plane?
horizontal/bottom
saccular macula is what directional plane
vertical
the utricle and the sacule have what gelatinous substance
calcium carbonate crystialis (otoliths or otoconia)
what does this gelatinous substance in the utricle and saccule do?
cuases extra thickness/denser than endolymph, which stimulates haircells
this gelatinous substance of the utricle and saccule is called
the otolithic membrane
the utricle is more sensitive to linear accelaration in the _________ plane
horizontal
the saccule is more sensitive to _____ accelartion
verticle linear acceleration
the haircells reside in the _______
vestibular ganglion
most primary vestibular afferents of the hair cells end in the ____
vestibular nuclei (rostral medulla, caudal pons)
axons carry vestibular info to the _____ (general large structure)
brainstem-- (vestibular nucleus R on each side)
from the brainstem, ipsilateral and bilateral connections for balance go to different parts of the CNS including
thalamus, cerebellum, and cranial nerves
what are the inputs for balalnce to vestibular nuclei
in addition to promary afferent CN 8, also from cerebellum (coordination), spinal cord (posture), vestibular nuclei from opposite side (work together)
what are the outputs for balance from the vestibular projection from the vestibular nuclei
goes through the thalamus to the cerebral cortex (conscious awareness of movement through space)
1.cerebellum-- coordination movement
2. reticular formation--motion sickness
3. SC-- regulation of posture and movements
inputs from visual system and joint and muscle receptors (where we are in spece) are also involved in____
balance
name a balance pathology and some etiologies of it and one possible compensation
pathology: vertigo- nonspecific symptom. Spinning sensation;

etiology: can be caused by a variety of disorders eg Meniere's Disease, (tinnitius, spinning, aural fullness),

compensation: sometimes one individual can use vision to compensate for loss of vestibular function (have patient close eyes)
taste is defined as a combination fo what 3 types of inputs
1. somatosensory inputs (temp, texture)
2. gustatory input- chemical stiumlation of taste buds
3. olfactory input- vapors stiumlate sense of smell (think cold)
stimulation of CN endings in oral and nasal cavities provide?
further pungency and spiciness
what are the 3 cranial nerves involved in taste
1. facial VII
2. glossopharyngeal IX
3. vagus X
where are the innervations of the cranial nerves encoded
in the receptor cells of the taste buds
where do taste buds live
on the bumps and folds (papillate) of the surface of the tongue
name 3 types of taste buds
1. fungiform- mushroom like, front portion, contain a few.
2. foliate- leaf life, back portion, dozens of taste buds
3. valliate- v shaped, contains 50% of taste buds, back portion make of 2/3 of these
which cranial nerve innervated the valliate
CN IX
which cranial nerve innervates the foliate
mostly CN IX but also CN 5
which cranial nerve innervates the fungiform and the andterior foliate
CN 5
where is the vagus nerve involved
in the small posterior
each taste bud is conprised of what type of cells?
1.taste receptor cells
2. supporting cells
3. basal cells
which cells replace the taste receptor cells
stem cells/basal cells
what type of cells are taste receptor cells
modified epithelial
how do taste receptor cells behave
like neurons-- depolarizaing; used different channels depending on food eg) sodium used in salty foods
what does taste reponse depend on
whole population of receptors. it takes a lot to perceive a flavor
taste receptor cells are not specialized. however______
taste receptor cells are not specialized: they respond to a wide range of tastes. any taste bud is capable of detecting all basic taste, however some happen to be more sensitive to certain tastes. no area is sensitive to just one taste.
name the 4 tastes
salty sweet bitter sour
which nerves carry taste into the brainstem; which neurons are they
facial, glossophayrngeal, and vagus nerve afferents

second order gustatory neurons
where in the brainstem do these neurons travel to
via solitary tract to the solitary nucleus
what are the second order gustatory neurons also involved in aside from taste
the motor component of coughing and swallowing
from the brainstem, second order gustatory neurons also go to the ______, _______, and _______
1. thalamus (conscous awareness of taste
2. hypothalamus
3. limbic lobe (more emotional/affective, effective of taste
where does smell begin
with olfactory epithelium in the nose
cells that project axons through the ethmoid bone CN 1 end in the _______
olfactory bulb
the olfactory epithelium has olfactory receptor neurons (single dendrite) which sends to the _______
olfactory vesicle
what is the olfactory vessicle
in mucous layer where odorants diffuse
discuss the lifespan of the olfactory receptor neurons
they are short-lived (like taste receptor neurons)
where are olfactory receptor neurons produced
in the olfactory receptor proteins
what do olfactory receptor proteins bind to and what does this binding result in
bind to odorants -- results in influx of NA polarization
what are the membranous characteristics of olfactory receptor proteins
thin and unmylenated-- slow conduction
where do olfactory neurons collect
in the olfactory filla (which pass through the ethmoid bone) end in olfactory bulb
what cranial nerve is composed of the olfactory filla
cranial nerve 1
what is contacted in the olfactory pathway
dendrites of other neurons
do axons emerging through the olfactory bulb go through the thalamus?
NO axons emerging through the olfactory bulb DO NOT go through the thalamus

instead they go through the piriform cortex (lower portion of each frontal lobe) and amygdala. It is uncrossed
loss of what two senses are closely linked
taste and smell
impaired olfaction also complain of impaired what
gustatation
what is the loss of the sense of smell called
anosmia
when does anosmia usually occur? what causes it?
after truama, degenerative disease, sensorineural disorders, tuumors; disconnect between olfactory receptor fibers and the olfactory bulb
what is it called when nothing is wrong with higher levels and it is the access that causes a loss of smell (it is seen with colds and allergies)
conductive anosmia
discuss the connections in and between the cerebral cortices
connections between the 2 hemispheres are called:
commisure fibers

connections within the 2 hemispheres are called:
association fibers
The cerebral cortex is connected by the corpus collosum and anterior commisure but each inner cortex is connected by association fibers
One functionally important association bundle which interconnects 2 prominant language areas
arcuate fasciculous
dominant hemisphere
left (nearly all right handed people and most laft handed)-- prominant in language, mathematical ability, logical sequence analysis
right hemisphere
spatial and musical patterns, better at problem solving with intuition, rhythm, more wholistic
most cerebral cortex is______
neocortex
neocortex
most of the cerebral cortex is in 6 or more distinct layers numbered 1-6 from the surface down
about 75% of all cortical nuerons are
pyramidal cells with apical dendrites, basal dendrites, and an axon
the remaining 25% of nonpyramidal cells size and function
small inhibatory interneurons with axons that do not leave the cortx
which areas are made up of small pyramidal and nonpyramidal cells
cortical areas that do not emit many long axons like primary sensory areas
which areas emit many long axons, like the motor cotex and are made of many large pyramydal cells
agranular areas
discuss the 2 main types of cells of the neocortex
granule cells and pyramidal cells
what are granule cells
small cells in layers 2&4 shorter axons and remain in cortex, sensory; usually signals input from the thalamus, connect to thalamic structures
what are pyramidal cells
larger and long axons (long distance) prosence indicates cortical connections or long distance connected, motor cortex has many pyramidal cells
name the 6 layers of the neorcortex
1) molecular layer
2) external granular layer
3) external pyramidal layer
4)internal granular layer
5) internal pyramidal layer
6) multiform layer (modified pyramidal)
what is the term for when it is hard to find boundaries between the layers (they invade eachother, not a perfect system)
heterotypical cortex
and the term for when there are very distinct boundaries?
homotypical cortex
what is the surface of the brain including lobes and insula
cerebral cortex
what is the "new bark" top/outer layer of the hemispheres, consisting of 6 layers with 2 types of cells but more of one type of cell
neocortex
what is the paleocortex
layer intermediate between the neocortex and the archiocortex; portion of the telencephalon (olfaction)
what is the archiocortex
polygenetically oldest, hippocampal structure
discuss the primary sensory cortices (where does input come from, what is represented, what layers, what cells)
receives input from the thalamus; represents the periphery eg. auditory has tonotopic map; layers 2&4; has presence of granule cells/input of thalamus "koniocortex"
what is koniocortex
cortical areas that have many G-cells (thalamic??)
what are the long distance pyramidal cells of the primary motor cortex called? where are they sent?
"Betz" cells sent to CT and CB tracts
which cortex is known as the agranular cortex
primary motor
what are the largest neurons in the CNS
Betz cells
what layer are Betz cells found in
layer 5 (internal pyramidal)
Name 4 important fasciculus and what they connect
1) superior longitudianal fasciculus/arcutate fasciculus-- conects temporal and frontal regions (brocas and wernike's

2) inferior longitudinal fasciculous-- connects temproal and occipital

3) superior and interior occipitofrontal fasciculous

4) cingulum
where do the primary sensory areas get their input from
the thalamus
where do the primary motor areas rise to
rise to CT tract
what four primary areas also have association areas next to them
visual, somatosensory, auditory, and limbic
what is the amygdala's role in memory
they amygdala's role in moemory information may be emotional information related to the experience
what is the hippocampus' role in memory
encoding new long-term memory formation but memory itself is diffuse
so bilateral damage to the hippocampus would cause what
impaired ability to form long-term memeories but you can learn new skills
what is the hypothalamus' main role
maintaining homeostasis
where does the hypothalamus receive information from
receives sensory information from the visceral, limbic, and retina
what are three types of amnesia
antrograde
retrograde
global
discuss antrograde amnesia
well
discuss retrograde amnesia
well
what types of lession are typical of global amnesia
bilateral limbic lesions
discuss broadman's areas and the main ones we should know (think language)
broca's and wernike's....
different types of memory underlying structures and deficits
well....
Given a structure, know if it's a sensory, motor, or association cortex
well...
long term memory
explicit (facts) and implicit (skills); 2 types episodic and semantic. episodic memore is explicit (hippocampus)
what is the timeline for short term memory
less than one minute
in contrast to unimodal inputs of the association areas, what is it called when there are lots of sensory-motor inputs (seen in the primary areas)containing:

"precise but distorted somatotopic, tonotopic,or retinotopic maps with large representations of functionally important areas like the fingers, the fovea, and speech frequencies"
heteromodal
what does the unimodal only apply to? what is it?
unimodal is what it sounds like-- single-function. it refers to the association areas because they have less precise somatotopic, tonotopic, and retinotopic maps than the primary areas, but their cells have more complex response properties.

the unimodal therefore only applies to association areas.
impaired ability to form long-term memeories but you can learn new skills

damage to what 2 structures may account for this?
bilateral damage to the hippocampus or diencephalon damage
the limbic system includes cortical or subcortical structures? the hippocampus is cortical or subcortical?
The limbic system includes both cortical and subcortical structures but the hippocampus is cortical.
where are emotion and memory performed in?
emotion and memory are not localized in one single structure but rather the whole system
what's included in the limbic lobe? (key structures)
1) hippocampus-- memory formation
2) amygdala- emotional expression (not only involved)
what structures make up the trunk of the temproal lobe
1) cingulate gyrus
2) parahippocampal gyri
3) hippocampual gyri
4) amygdala
4) septal nuclei