Neuro: Test 2 : 10. Schriefer : Anti-Anxiety

Front 1

Chlordiazepoxide is what kind of drug?

Back 1

Benzodiazapine

anti-anxiety

BDZ-GABA-chloride ionophore (ligand –gated ion channel).
Benzodiazepines facilitate the effect of GABA stimulation of GABAA receptors leading to increased chloride permeability and increased inhibition.

Front 2

What are the pharmacologic properties of the benzos?

***

Back 2

you can give them and they have a ceiling effect (at a certain point giving more drug will not increase effect/lead to tox) unless you wash them down with booze

also will not have large hypnotic effect

Front 3

Diazepam

Back 3

Benzodiazapine

anti-anxiety

BDZ-GABA-chloride ionophore (ligand –gated ion channel).
Benzodiazepines facilitate the effect of GABA stimulation of GABAA receptors leading to increased chloride permeability and increased inhibition.

Front 4

Oxazepam

Back 4

Benzodiazapine

anti-anxiety

BDZ-GABA-chloride ionophore (ligand –gated ion channel).
Benzodiazepines facilitate the effect of GABA stimulation of GABAA receptors leading to increased chloride permeability and increased inhibition.

Front 5

Lorazepam

Back 5

Benzodiazapine

anti-anxiety

BDZ-GABA-chloride ionophore (ligand –gated ion channel).
Benzodiazepines facilitate the effect of GABA stimulation of GABAA receptors leading to increased chloride permeability and increased inhibition.

Front 6

Clorazepate

Back 6

Benzodiazapine

anti-anxiety

BDZ-GABA-chloride ionophore (ligand –gated ion channel).
Benzodiazepines facilitate the effect of GABA stimulation of GABAA receptors leading to increased chloride permeability and increased inhibition.

Front 7

Prazepam

Back 7

Benzodiazapine

anti-anxiety

BDZ-GABA-chloride ionophore (ligand –gated ion channel).
Benzodiazepines facilitate the effect of GABA stimulation of GABAA receptors leading to increased chloride permeability and increased inhibition.

Front 8

Alprazolam

Back 8

Benzodiazapine

anti-anxiety

BDZ-GABA-chloride ionophore (ligand –gated ion channel).
Benzodiazepines facilitate the effect of GABA stimulation of GABAA receptors leading to increased chloride permeability and increased inhibition.

Front 9

Drowsiness, ataxia, confusion, headache, euphoria, fatigue
Paradoxical hyperexcitability,
increased anxiety, insomnia

side effects of?

Back 9

Benzodiazepines

Front 10

What drug for anti anxiety will you use for older pts or pts with poor liver function?

*****TEST

Back 10

Oxazepam or Lorazepam

they only take one step to get metabolized

Front 11

if a person is being treated for alcohol withdrawal what can you use to tx them?

Back 11

Benzodiazepines

Front 12

what 2 commonly used stimulants will decrease the effects of benzos?

Back 12

Smoking – decrease effect
Caffeine – decrease effect

Front 13

what effect do SSRIs and grapefruit juice have on benzos?

Back 13

SSRIs, grapefruit juice inhibit CYP3A4 and increase BZD levels

Front 14

effect of alcohol on benzos?

*

Back 14

CNS depressants including alcohol – enhancement

Front 15

What kind of drug is Buspirone? moa?

Back 15

anti depressant that can be used for anti-anxiety

. It appears to reduce anxiety by acting as a partial 5HT1A agonist.
It also differs from the benzodiazepines in that there is a delayed onset of activity, less sedation, no anticonvulsant activity, no muscle relaxation, and no potential for abuse. It does not potentiate CNS depressants such as alcohol.

Front 16

what kind of drug is clomipramine? moa? use?

Back 16

A tricyclic used in the treatment of obsessive-compulsive disorder (CD). 5HT reuptake blocker. Fluvoxamine and alprozolam also used

Front 17

for chronic anxiety what kind of drug do you want to use?

***

Back 17

SSRI

less abuse

Front 18

Anxiety in response to illness – drug of choice?

Back 18

benzo

Front 19

Generalized anxiety disorder – drug of choice?

Back 19

SSRI, buspirone, benzodiazepines

Front 20

Social phobia –therapy of choice?

Back 20

cognitive behavioral therapy, SSRI, clonazepam

Front 21

Performance anxiety – drug of choice?

Back 21

b blocker

Front 22

Panic Disorder – drug of choice?

Back 22

SSRI

Front 23

why do you have to be careful giving benzos to old folks?

*

Back 23

FALLS and liver problems

For elderly patients (or patients with liver cirrhosis) reduce the dosage of chlordiazepoxide and diazepam, or prescribe oxazepam and lorazepam as alternatives

Front 24

goal of Pharm. treatment of spasticity?

Back 24

Goal is to decrease activity of Ia neurons activating primary motor neurons or to increase activity of inhibitory internuncial neurons.

Front 25

Baclofen is what kind of drug? use?

Back 25

An agonist at GABAB receptors;
its action results in increased K+ conductance and hyperpolarization of neurons.
This results in inhibition of glutamate neurons in brain and spinal cord, and , thus, relaxation of muscles-->spasticity

Front 26

Tizanidine moa? use?

Back 26

An α2-adrenergic agonist (similar to clonidine);
Potentiates pre- and post-synaptic inhibition in spinal cord.-->used in spasticity


Adverse reactions
Drowsiness
Dry mouth
Hypotension
Weakness

Front 27

Dantrolene moa? uses?

Back 27

Blocks the rayanodine receptor channel, which, in turn, interferes with excitation-contraction coupling in skeletal muscle.

used for spactisity and malignant hyperthermia