Neuro: Test 1 : 27. Schriefer : Antipsychotic Agents

Front 1

All anti-psychotics share what mechanism in common?

Back 1

block D2 receptors

(both typical and atypical)

but the importance of this in relation to other receptor actions varies from drug to drug

Front 2

Please compare the difference in typical anti-psychotics and atypical's tendency to bind to different receptors

Back 2

“Atypical” antipsychotics have different receptor binding profiles, but they all tend to be less potent at D2 receptors than chlorpromazine or halperidol and more potent at 5HT2 and D4 receptors.

Front 3

how does blocking D2 receptors help with Schizophrenia?

Back 3

alleviates positive symptoms of schizophrenia (tension, hostility, hyperactivity, combativeness, hallucinations, delusions, insomnia, and anorexia.

Front 4

how does blocking D4 and 5HT2 receptors help with SZ?

Back 4

Blocking D4 and 5HT2 receptors may alleviate negative symptoms (apathy, withdrawal, unresponsiveness).

Front 5

which is more likely to make you want to eat more, typical or atypical antipsychotics?

Back 5

Atypical

Front 6

how do anti-psychotic drugs affect the ANS?

Back 6

peripheral cholinergic block, a-adrenergic block

Front 7

most important side effects of anti-psychotic drugs

Back 7

– CV, endocrine, central and autonomic are most important. Other dangerous effects include seizures, agranulocytosis and pigmentary degeneration of retina

Front 8

Halloperidol is more likely to cause what serious side effect? is this a typical or atypical anti-psychotic?

**

Back 8

Tardive dyskinesia

Typical-D2 block

Front 9

clozapine is likely to cause what side effect? is this a typical or atypical antipsychotic?

Back 9

Seizures

Atypical-Blocks D4 and 5HT > D2

Front 10

what 2 antipsychotic drugs cause QT prolongation

Back 10

thioridazine (typical)

ziprasidone (atypical)

Front 11

in elderly pts on risperidone what do you have to worry about?

what is another drug that can cause this?

Back 11

STROKE

Olanzapine

(these are atypical anti-psychotics)

Front 12

what 2 anti-psychotic drugs are likely to cause weight gain?

Back 12

clozapine and olanzapine

(atypical)

Front 13

Most serious adverse affect of Clozapine? When would you use it?

Back 13

mild leukocytosis, leukopenia, and eosinophilia. Bone marrow suppression or agranulocytosis with clozapine

Last resort drug

atypical anti-psychotic

note: can also cause seizure and weight gain

Front 14

Phenothiazines is also known as?

Back 14

Chlorpromazine

or

Fluphenazine

(typical anti-psychotics)

Front 15

Butyrophenone is what drug?

Back 15

Haloperidol

(typical)

Front 16

All anti-psychotic agents improve positive symptoms, which improve negative sx?

Back 16

Atypicals

Front 17

2 side effects of Atypicals in general?

Back 17

weight gain and diabetes

Front 18

what type of treatment will lead to low number of re-hospitalizations of schizophrenic patients?

Back 18

Drug therapy + social therapy

Front 19

Chlorpromazine (Thorazine)
Thioridazine (Mellaril)
Fluphenazine (Prolixin)
Perphenazine (Trilafon)
Thiothixene (Navane)
Haloperidol (Haldol)
Loxapine (Loxitane)

Back 19

Typical Anti-psychotics

Front 20

Clozapine (Clozaril)
Risperidone (Risperdal) Paliperidone (Invega)
Olanzapine (Zyprexa)
Quetiapine (Seroquel)
Ziprasidone (Geodon)
Aripiprazole (Abilify)
Asenapine (Safris)
Iloperidone (Fanapt)

Back 20

Atypical Anti-psychotics