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30 Cards in this Set
- Front
- Back
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What structure separates the ant, medial, and lateral thalamic nuclei groups?
What nucleus is located in this structure? |
Internal Medullary Lamina
CM nucleus |
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What thalamic structures are seen at the thalamic adhesion level?
Subthalamic Nucleus level? Red Nucleus Level? |
Ant and VA/VL
LD and VL, VPL, VPM LP and VPL, VPM |
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An olfactory neuron has a ____ apical process that contains a GPCR that _____ to cause an increase in calcium. The neuron regenerates every _____
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ciliated
increases cAMP month |
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A taste sensory cell has a ____ apical process that extends through the taste pore. The cell regenerates every _____.
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microvilli
10 days |
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Which chemo agents may cause....
a) distal sensory neuropathy b) painful sensory neuropathy c) aspetic meningitis & encephalitis |
a) Thalidomide
b) Bortezomib c) methotrexate (given intrathecally or via IV w/ levocorin rescue) |
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What drug is given to treat brain edema caused by cancer-induced breakdown of the BBB?
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Dexomethotrexate - works by increases VEGF and stimulating fluid mvmt.
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What is the chemo treatment of choice for Glioblastoma Multiformes?
How can you predict a patient's responsiveness to this treatment? |
Temozolomide
measure methylation of MGMT (more methy = more responsive!) |
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What mutation predicts a better prognosis for Oligodendroglioma?
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1p19q co-deletion
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What is the treatment of choice for CNS lymphoma?
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Methotrexate w/ Levocorin rescue
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What artery would be effected if a patient complains of non-leg-sparing paralysis and inability to voluntarily void bladder?
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ACA
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What artery would be effected if a patient complains of leg-sparing paralysis and Broca's aphasia?
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sup. MCA
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What artery would be effected if a patient complains of hemi-neglect, asteri/agraphesthesia, Wernicke's aphasia, and contra homonymous hemianopia?
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Inf. MCA
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What artery would be effected if a patient complains of contra homonymous hemianopia with macula sparing?
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PCA
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What artery would be effected if a patient complains of Locked-In syndrome, decere/decorticate posture, CN 3 palsy?
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Top of Basilar
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What artery would be effected if a patient complains of vertigo, ataxia, diplopia?
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Vertebro-Basilar
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What artery would be effected if a patient complains of monocular vision loss, paralysis/numbness, language difficulties?
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Carotid (ant stroke)
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Which part of the cortex would cause the following symptoms when lesioned: prospagnosia, achromatopsia, micro/macropsia?
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Inf. Occipital-Temporal
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Which part of the cortex would cause the following symptoms when lesioned: Balint's Syndrome?
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Dorsolateral Parieto-Occiptial
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Which part of the cortex would cause the following symptoms when lesioned: hemineglect with asnognosia
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posterior parietal
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Wrong word phenomena, or ______ , is characteristic of ____ aphasia.
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paraphasia
Wernickes |
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common migraine
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no aura, but photo/phonophobia present
require at least 5 attacks for diagnosis |
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classic migraine
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AURA, w/ gradual onset of aura symptoms over 4 min
require at least 2 attacks for diagnosis |
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What genetic defects re responsible for familial hemiplegic migraine?
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. CACNA1A (chr 19/1) = GOF of Cav channels
. ATP1A2 = LOF of ATPase (cause decrease glut reuptake) . SCN1A = either GOF Nav1.1 or LOF in GABA . AD double (-) mutation in TREK K+ channel = hyperpolarizing current |
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What is the mechanism of action of triptans (sumiptran and Rizotriptan)
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agonists for 5HT 1B/1D receptors causing direct vasoconstriction, slowed pain conduction, decrease in CGRP neuropeptides
SE = chest pain |
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What is the treatment of choice for status migranosus
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IV Dihydroergotamine
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What agents are used for migraine prophylaxis?
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Cyproheptadine/Methysergide
Topiramate/Valproate (AEDs) B-blockers Antidepressants |
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What is an expected side effect of a D2 dopa receptor blocking antipsychotic?
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Hyperprolactinemia - breast leakage, gynomastia, decreased libido, infertility, impotence
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What are the 3 parts of the amygdala and their fxns?
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1) Central - output for fear/rage/autonomics
2) Basolateral - receives sensory input and relays to central 3) Corticomedial - receives olfactory input and associates it w/ olfactory memory or sexual behavior |
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Which part of the hippocampus is associated with Alzheimers?
Benign forgetfullness? |
Entorhinal
Subiculum |
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Give the Papez circuit path.
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Cingulate Gyrus ->
Enterohinal -> Subiculum -> Fornix -> Mammillary bodies -> MTT -> Ant. thalamic nucleus -> Cingulate |
