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48 Cards in this Set
- Front
- Back
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Roles of the immune system
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$1.JPG'>
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Which diseases have been significantly affected by vaccinations
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$2.JPG'>
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when did adaptive immunity appear in evolution
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$3.JPG'>
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what cells are involved in innate immunity
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$4.JPG'>
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what cells are involved in adaptive immunity
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$5.JPG'>
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The initial response to microbes of the innate immune reponse
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$6.JPG'>
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what are the barrier componenets
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$7.JPG'>
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what are the circulating effector cells
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$8.JPG'>
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what are the circulating effector proteins
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$9.JPG'>
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what are the first responders of the immune system
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neutrophils followed by called macrophages
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what are the lymphoid cells of the innate system
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NK cells
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<img src='01-02_ImmuneIntro_Preview/Preview_$A$12.JPG'>
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$12.JPG'>
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What are PAMPS and DAMPS
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$13.JPG'>
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Danger associated molecules
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PAMPS and DAMPS
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What is a PRR
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pattern recognition receptors - recognize a PAMP
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Examples of PAMPS
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$16.JPG'>
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2 types of pattern recognition receptors
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$17.JPG'>
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Cellular locations of PRRs (divide and memorize this slide)
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$18.JPG'>
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Most important TLR's
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2 and 4
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<img src='01-02_ImmuneIntro_Preview/Preview_$A$20.JPG'>
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$20.JPG'>
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Father of immunology
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edward jenner
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Year of first successful vaccination
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1798, by Edward Jenner against smallpox
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Roles of the immune system
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Defense against infections, responds to tissue grafts and newly introduced proteins, defense against tumorsw
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What are the important categories of innate immune response
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Microb prevents, control & elimination - Injury inflammation and antiviral state - Stimulate the adaptive immunity
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What is a TLR
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Innate Toll-like receptors that recognize pathogens
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What are the suface TLR's
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Bacterial cell walls and molecules(TLR 1,2,6), TLR 4 (LPS of Gram-negative bacteria), TLR(5) flagellin of various bacteria
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What are the endosomal TLR's
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Viral (TLR 3 binds to ds-RNA, TLR7 & 8 bind to SS-viral bacterial RNA), TLR9 binds to bacterial unmethylated cpg acteria and viral DNA)
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What is a NOD
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Nuclear oligomerization domain - a type of TLR-like recognition factor.
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What are the cytoplasmic sensors for the innate reponse
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bacterial (NLR), NOD1 (binds to peptidoglycans from gram negative bacteria) NOD2, binds to peptidoglycans from gram-postive bacteria, RIG1 - binds to HCV RNA)
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What is a RIG
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Rig Like Receptors - a type of innate receptor like a TLR that recognizes viral particles
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What do TLR's do?
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active similar signaling pathways on recognition of microbial ligans. Express genes for cytokin/chemokin production
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What is NF kappa B
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Nuclear factor Kappa B. A transcription factor that activates the transcription of adhesion molecules
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What is IRF-3
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type 1 interferon blocks viral replication
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TLR1
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$34.JPG'>
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TLR2
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$35.JPG'>
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TLR6
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$36.JPG'>
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TLR4
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$37.JPG'>
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TLR5
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$38.JPG'>
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TLR3
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$39.JPG'>
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TLR7
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$40.JPG'>
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TLR8
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$41.JPG'>
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TLR9
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$42.JPG'>
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NLR
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$43.JPG'>
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Inflammasome
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a complex formed by cells that have activated NLR's that induced cleavage and activation of caspase01 forcing secretion of IL-1beta and IL-18
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IL-1Beta
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$45.JPG'>
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IL-18
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$46.JPG'>
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clinical relevance of TLR's
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<img src='01-02_ImmuneIntro_Preview/Preview_$B$47.JPG'>
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