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10 Cards in this Set
- Front
- Back
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Phenytoin
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- AED for partial and tonic-clonic seizures
- interacts w/ CYP2C9 and CYP2C19 |
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Carbamazepine
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- AED for partial and tonic-clonic seizures
- interacts w/ CYP3A4, CYP2C8, CYP1A2 |
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Lamotrigine
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- AED for partial and mixed seizures
- May interfere with pathologic glutamate release - interacts w/ UGT 1A4 |
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topiramate
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- AED for partial and tonic-clonic seizures
- antagonizes glutamate action at AMPA/kainate GluR’s and inhibits carbonic anhydrase |
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Barbiturates for epilepsy
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- phenobarbitol
- for partial and tonic-clonic seizures, and status epilepticus - prolong GABA-mediated chloride channel openings |
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gabapentin
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- for partial and tonic-clonic seizures
- increase neuronal GABA concentration - enhances GABA transmission, etc |
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valproate
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- for partial, tonic-clonic, and abscence seizures
- increase neuronal GABA concentration - enhances GABA transmission, etc |
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ethosuximide
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- for abscence seizures
– Blocks “transient” (T-type) calcium channels |
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benzodiazapine for epilepsy
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- diazepam
- for status epilepticus |
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fosphenytoin
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a phenytoin for status epilepticus
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