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12 Cards in this Set
- Front
- Back
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barb interactions
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- phenobarbital + cimetidine, erythromycin, clarithromycin, or fluconazole means increased phenobarb
– phenobarbital + rifampin means decreased phenobarb |
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long-acting benzos for anxiety
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- b/c long-lasting active metabolite Nordiazepam
- diazepam, flurazepam, chlordiazepoxide, cloraze-pate - more daytime sleepiness |
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shorter-acting benzo's for anxiety
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- triazolam and midazolam (for unconcious sedation)
- more sever withdrawl |
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intermediate acting benzo's for anxiety
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lorazepam, alprazolam, temazepam
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what decreases benzo level
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rifampin, food, antacids
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what increases benzo level
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Cimetidine, disulfiram, isoniazid, and estrogen
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benzos increase the level of
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phenytoin, digoxin
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Panic Disorder tx
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– 1) TCA's (imipramine, clomipramine)
– 2) SSRI's (gold for PD and SAD) – 3) SNRIs – 4) benzo’s (alprazolam, clonazepam, lorazepam) – 5) MAOI's for refractory cases due to SE profile – initiate at low doses then titrate to avoid temporary worsening of panic sx |
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OCD tx
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– Only effective work w/ S
– Clomipramine (TCA) - 4 SSRIs – fluoxetine, sertraline, paroxetine, and fluvoxamine |
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PTSD tx
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– SSRIs first-line
- sertraline and paroxetine have FDA approval |
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GAD tx
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- BZDs were used, now
– Buspirone – The SNRI, venlafaxine – SSRIs paroxetine and citalopram |
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Social Anxiety Disorder tx
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- MAOs OK, but SSRIs 1st line
– sertraline, paroxetine, venlafaxine – Benzos or β-blockers sometimes uses (performance anxiety) |
