Neuro - Movement Disorders

Front 1

Parkinson's Dz: which more common:

Sporadic or Familial?

Back 1

Sporadic

Front 2

Parkinson's Dz:

Familial 2/2 mutations in what TWO GENES?

Back 2

Alpha-synuclein
Parkin

Front 3

What dz:

Mutate alpha-synuclein

Back 3

Parkinson's

Front 4

What dz:

Destroy DA neurons in Sub Nigra Pars Compacta

Back 4

Parkinson's

Front 5

PD: destroy ventral or dorsal layer of Sub Nigra?

Back 5

Ventral

Front 6

PD:

Dopaminergic neurons in SNPC also contain what other protein?

Back 6

Neuromelanin

Front 7

PD: see Lewy bodies?

Back 7

Yes

Front 8

Parkinson's:

-tremor is what speed? (Hz)
-worse with action or rest?
-more common prox or distal arm?

Back 8

Slow: 3-5Hz

Worse at rest

Prox arm

Front 9

What dz:

LEAD PIPE rigidity

Back 9

PD

(same thing as cogwheel rigid)

Front 10

PD: cogwheel rigidity worse in DISTAL LIMBS or AXIAL MUSC?

Back 10

Distal limbs

Front 11

PD: postural instability is 2/2 what change?

Back 11

IMPAIRED POSTURAL REFLEXES

Front 12

PD: what % pts develop dementia?

Back 12

25%

Front 13

L-DOPA: cross BBB?

Back 13

YES

(contrast dopamine)

Front 14

Name for:

Periph decarboxylase inhibitor --> prevents periph S/E of DA agonist

Back 14

Carbidopa

Front 15

L-dopa: what effects in PERIPH?

Back 15

n/v/HTN

Front 16

Name for med:

L-dopa + carbidopa

Back 16

Sinemet

Front 17

PD:

Anticholinergics tx which feature of dz?

Back 17

TREMOR

Front 18

PD:

What drug class txs TREMOR

Back 18

Anticholinergics

Front 19

PD:

What drug txs bradykinesia, rigidity & gait atax?

Back 19

Amantadine

Front 20

What dz:

Amantadine

Back 20

PD (txs rigidity, brady, gait atax)

Front 21

PD: Amantadine txs what sxs?

Back 21

Brady, rigid, atax

Front 22

Selegiline: what drug class? txs what dz?

Back 22

Selective MAO-B inhibitor

PD

Front 23

PD: what is mxn of COMT inhibitors?

Back 23

Augment L-Dopa

Front 24

Progressive Supranuclear Palsy:

Which more impaired: vertical or horiz gaze?

Back 24

VERTICAL

Front 25

What dz:

Impaired vertical gaze; axial rigid (inv neck extens) w/early falls

Back 25

Progressive Supranuclear Palsy

Front 26

Progressive Supranuclear Palsy:

Inv neck flexors or extensors?

Back 26

Rigid extensors --> axial rigid --> early falls

Front 27

Progressive Supranuclear Palsy:

Fall early or late in dz?

Back 27

Early

Front 28

What dz:

Apraxia; sensory impairment; ALIEN LIMB; severe UNIlat rigidity; stimulus-sensitive myoclonus

Back 28

Corticobasal Ganglionic Degeneration

Front 29

Corticobasal Ganglionic Degeneration:

-impaired sensory?
-uni/bilat rigidity?
-difficulty w/what actions?

Back 29

Sens impaired
UNILAT rigidity
Stimulus-sensitive myoclonus
APRAXIA; ALIEN LIMB

Front 30

Diffuse Lewy Body Dz:

-dementia early or late?
-what type of hallucins?
-hypersensitive to which drug class?

Back 30

Early dementia
VISUAL HALLUCIN

do NOT give neuroleptics

Front 31

What dz:

Early dementia; visual hallucinations; hypersens to neuroleptics

Back 31

Lewy Body Dementia

Front 32

Another name for:

LOWER HALF PD

Back 32

Vascular parkinsonism

Front 33

Vascular Parkinsonism: classic feature?

Back 33

LOWER HALF PD

Rigid legs --> impaired gait

Front 34

Multiple System Atrophy:

-ANS dysfxn early or late?
-paresis of which muscles?

Back 34

Early ANS dysfxn

Vocal Cord paresis

Front 35

What dz:

Early ANS dysfxn; corticospinal tract dysfxn; cerebellar signs; vocal cord paresis

Back 35

Multiple System Atrophy