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10 Cards in this Set
- Front
- Back
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what is habituation vs sensitization?
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- habituation: decreasing response to sensory stimuli
- sensitization: increasing response to sensory stimuli |
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how do habituation & sensitization happen at a molecular level?
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- habituation: vesicles released decreases b/w sensory & motor neuron
- sensitization: - short term: 5HT from interneuron --> cAMP --> PKA --> phosphorylate K channels --> more Ca influx --> release of glutamate from sensory to motor (stronger) - long term: increased PKA --> phosphorylate other proteins (CREB) --> transcription changes |
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what is the molecular difference between short & long term sensitization?
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- - short term: 5HT from interneuron --> cAMP --> PKA --> phosphorylate K channels --> more Ca influx --> release of glutamate from sensory to motor (stronger)
- long term: increased PKA --> phosphorylate other proteins (CREB) --> transcription changes |
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what is associative conditioning?
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- associating two sensory stimuli
- same as classical conditioning |
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how does information flow in the hippocampus?
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- EC --> dentate gyrus --> CA3 --> CA1 --> EC
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what does tetanus do to LTP?
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- repetitive stimulus increases the synaptic strength & makes stable increased current flow = LTP
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what is associative LTP?
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- when you have tetenus at top on one synapse and single synapse below - cell already depolarized enough that Mg out of NMDA so you can use NMDA receptor
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what is the difference between early & late LTP?
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- early LTP: 1-2 hours, short term memory
- late LTP: days-weeks, long term memory |
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what are the molecular mechanisms for LTP?
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- increase in Ca --> activate kinases --> phosphorylate receptors
- phosphorylate AMPA receptors & move them from vesicles to the synaptic cleft & release them so they start functioning |
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what do short term sensitization & early LTP require? long term & late LTP?
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- require phosphorylation
- require protein synthesis (CREB phosphorylation increasing transcription) |
