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173 Cards in this Set

  • Front
  • Back
length of brainstem
7 cm
brainstem links ____ to _____
brainstem links forebrain to spinal cord & cerebellum
2 parts of forebrain
diencephalon

cerebral hemispheres
neuronal cell groups found in brainstem
nuclei
3 regions of brainstem
midbrain

pons

medulla
6 things the Reticular Formation controls
control of respiration

consciousness

painperception

CV function

motor coordination

muscle tone
describe normal position of brainstem
rests on occipital bone of posterior cranial fossa

positioned almost vertical

Medulla extends caudally through Foramen Magnum
At the level of which structure does the axis of orientation rotate 90*?
level of the thalamus (diencephalon)
describe directions rostral, caudal, ventral, dorsal after level of thalamus
rostral - toward forehead
caudal - toward occipitus
ventral - toward feet
dorsal - toward top of head
Is the thalamus part of the diencephalon or the brainstem?
diencephalon
Which structures comprise the tectum of the midbrain?
Left and right superior and inferior colliculi (4 hills)
Superior colliculi process what type of information?
visual
Inferior colliculi process what type of information?
auditory
Parinaud syndrome
compression of Superior Colliculus


due to tumor of adjacent pineal gland

paralysis of upward gaze
Only cranial nerve to exit the dorsal surface of the brainstem

where does it emerge?
trochlear nerve (CN IV)

emerges from midbrain just caudal to inferior colliculus
what neural structure covers the fourth ventrical?
cerebellum
rostral 2/3 of the floor of the 4th ventrical comprises...
the dorsal aspect of the pons
caudal 1/3 of the floor of the 4th ventrical comprises...
dorsal aspect of the rostral medulla
what three structures surround the rostral and lateral borders of the fourth ventrical?
superior, middle and inferior cerebellar peduncles
fiber tract that connects neurons in the cerebellum with those in the thalamus
superior cerebellar peduncle
fiber tract that connects neurons in the cerebellum with those in the pons
middle cerebellar peduncle
fiber tract that connects neruons in the cerebellum with those in the spinal cord
inferior cerebellar peduncle
2 small elevations caudal to the 4th ventrical
gracilis tubercle

cuneate tubercle
the gracilis and cuneate tubercles mark the locations of which nuclei?
gracilis and cuneatus nunclei
neurons in the nucleus gracilis and nucleus cuneatus receive information about which three senses?

through which structures
discriminative touch
proprioception
vibration

through the gracilis and cuneatus fasciculi
the fasciculus gracilis and fasciculus cuneatus are apparent on which aspect of the medulla?
horizontal ridges on DORSAL SURFACE of Medulla
neurons within the gracilis and cuneate nuclei give rise to axons that go where?
cross the midline and
ascend through the brainstem
to the contralateral thalamus
as the medial lemniscus
where is the Crus Cerebri found?
ventral surface of the midbrain
describe fibers in the Crus Cerebri
primarily descending Corticospinal and Corticobulbar fibers

destined to innervate motor neurons
corticobulbar fibers connect which two areas of the brain
cerebral cortex & brainstem
pathway of pontocerebellar fibers
originate from neurons in the ventral pons

desinted for the contralateral cerebellum via the middle cerebellar peduncle
function of pontine nuclei
coordination of movement

receive descending cortical input
represent important connection between cortex & cerebellum
location of pyramids
extend caudally from the pons along ventral surface of medulla
majority of fibers in pyramids
descending corticospinal axons that originated in ipsilateral motor cortex

destined for motor neurons in contralateral spinal cord
where is the pyramidal decussation?
caudal end of the medulla
describe the majority of fibers that ross at the pyramidal decussation
descend in lateral funiculus of spinal cord as the

lateral corticospinal tract

responsible for voluntary movement of the limbs
Frontal Eye Fields
region of cortex rostral to Primary Motor Cortex

Frontal Eye Field neurons activate brainstem motor nuclei to initiate voluntary movement of the eyes
uncrossed corticospinal fibers continue past the pyramidal decussation as which tract?
anterior corticospinal tract

(little clinical significance)
Corticospinal (pyramidal) tract

origin
ending
function
Corticospinal tract

origin: motor cortex
ending: ventral horn cells of SC
function: voluntary movement of limbs
Corticobulbar tract

origin
ending
function
corticobulbar tract

origin: mortor cortex
ending: brainstem motor nuclei
function: motor control of the head & neck
DC-ML tract

origin
ending
function
DC-ML tract

origin: sensory receptors in limbs/trunk
ending: ipsidlateral N. gracilis/Cuneatus via dorsal columnas

Ending: contralateral thalmus via medial lemniscus

Function: discriminative tough, vibration, proprioception
AL system

origin
ending
function
AL system

origin: sensory receptors in limbs
ending: contralateral thalamus
function: pain, temp, crude touch
trigeminothalamic tract

origin
ending
function
trigeminothalamic tract

origin: skin, spinal nucleus of CN V (brainstem)

ending: contralateral thalamus

function: discriminative touch, vibration, temp, pain, proprioception from head
UMNs definition
neurons that give rise to a motor pathway, but do not interact directly with the target musle
LMNs definition
neurons whose axons innervate the target muscle
where are the UMNs in the corticospinal and corticobulbar pathways located?
primary motor cortex
where are the LMNs in the corticospinal and corticobulbar pathways found?
ventral horns of spinal cord

various motor nuclei of brainstem
5 signs of UMN syndrome
Paresis (weakness) or Plegia (paralysis) of muscle

Spasticity - increased resistance to passive stretch

hyperreflexia - exaggerated DTGs

NO wasting of muscles

positive Babinski
5 signs of LMN syndrome
Paresis or Plegia of muscle

flaccid paralysis/hypotonia

hyporeflexia

muscle atrophy

fasciculations
blood supply to brainstem provided primarily by branches of which 2 arteries?
vertebral & basilar
primary branches of vertebrobasilar system in medulla
anterior spinal aa
posterior spinal aa
posterior inferior cerebellar artery (PICA)
blockage of PICA results in which syndrome?

affected region?
Lateral Medullary (Wallenberg's) Syndrome

dorsal-lateral region of medulla affected
6 deficits seen in Wallenberg's syndrome
contralateral loss of pain & temperature from body (AL system)

ipsilateral loss of pain and temp from face (spinal trigeminal nucleus)

vertigo and nystagmus (vestibular nuclei)

loss of taste from ipsilateral half of tongue (nucleus solitarius)

hoarseness and dysphagia (nucleus ambiguus and CNs 9&10)
Summary of Wallengbert's syndrome
aka: Lateral Medullary SUndrome

ipsilateral loss of pain and temp from face

contralateral loss of pain and temp from body
Primary blood supply from Pons
Paramedian and Circumferential branches of Basilar artery
The labyrinthe artery is a branch of which artery?
AICA
which two CNs does the AICA serve?
CN VII and CN VIII

within the internal auditory meatus
Which arteries does the SUperior Cerebellar artery supplement?

where?
Superior Cerebellar artery supplements the Paramedian and Circumferential aa in the rostral portion of the Pons, starting at the level of CN V
arteries serving central region of midbrain
Posteromedial group

arise from Posterior Cerebral a.
Mnemonic for sensory/motor/both CNs
Some Say Marry Money But My Brother Says Big Boobs Matter More
these CNs attach directly to the forebrain & therefore do not have brainstem components
CN I

CN II
relationship between nuclei of similar function and origin
discontinuous columns of cells
example of discontinuous alignment of nuclei:

motor nuclei that serve cranial nerves III, IV, VI and XII
all contain GSEs
all are found adjacent to the midline
example of discontinous alignment of nuclei

Motor Nucleus of V
Facial Motor Nucleus of VII
Nucleus Ambiguus
Spinal Accessory Nucelus
all have components that innervate musculature derived from embryonic gill arches (Special Visceral Efferent)

all found lateral
what does somatic motor component of the oculomotor nerve do?
innervates 4 of 6 extraocular muscles
what does parasympathetic component of the oculomotor nerve do?
innervates smooth muscles within eye:
iris sphincter
ciliary muscles
where are somatic motor neurons of oculomotor nerve located
Oculomotor nucleus
just ventral to periaqueductal grey of the midbrain
at leavel of the Superior Colliculus
From where do preganglionic parasympthathetic fibers of the oculomotor nerve originate?
Edinger-Westphal Nucleus
Where do somatic and parasympathetic fibers of CN III join?
join within brainstem
Pathway of CN III
courses ventrally through Red Nucleus
exit Brainstem as CN III along medial aspect of Crus Cerebri in Interpeduncular Fossa

passes btw Posterior Cerebral and Superior Cerebellar aa

runs anteriorly within wall of Cavernous Sinus

enters orbit via Superior Orbital Fissure
which muscles does superior branch of CN III serve?
superior rectus

levator palpebrae superioris
which muscles does inferior branch of CN III serve?
inferior rectus

inferior oblique

medial rectus
which branch of CN III do the preganglionic parasympathetics follow?

where do they synapse?
follow inferior branch

synapse within Ciliary Ganglion
which other fibers do post-ganglionic parasympathetic fibers from CN III run with?
sympathetic postganglionics from the ipsilateral Superior Cervical Ganglion
what do ciliary muscles control?
refractive power of lens
location & function of Medial Longitudinal Fasciculus (MLF)
adjacent to oculomotor nucleus

fiber tract by which ocular motor nuclei communicate

plays important role in coordinated movements of the eyes
intorsion
rotation of the top of the eye inward
extorsion
rotation of the top of the eye outward
actions of superior rectus
elevates and adducts
actions of inferior rectus
depresses and adducts
actions of medial rectus
adducts
actions of inferior oblique
elevates and abducts
oculomotor-related deficits generally occur as a result of injury to _____ and not to _____
oculomotor-related deficits generally occur as a result of injury to CN III and not to the Oculomotor Nucleus itself
4 causes of injury to CN III
aneurysm - Posterior and Superior Cerebellar aa

rapid swelling causing brain displacement - tumor, trauma, epidural hematoma

infection/inflammation within Cavernous Sinus

syphylitic and tuberculous meningitis, which localize btw optic chiasm & temporal lobe
external signs of somatic CN III damage
Divergent Strabismus (outward deviation of the eye)

Diplopia

Ptosis
external signs of parasympathetic CN III damage
Mydriasis (pupillary dilation)

loss of pupillary light reflex

loss of accommodation

abnormal near response
near response
pupillary constriction (closer object gets, the more light it reflecs)

accommodation (increased focusing power of the lens)

convergence of the eyes (due to bilateral input to the medial rectus)
Anterior Alternating Hemiplegia (Weber's Syndrome)
lesion affects CN III and adjacent corticospinal fibers

--> ipsilateral ophthalmoplegia (eye paralysis)

--> contralateral hemiparesis (paralysis of limbs on one side)
Why is hemiparesis contralateral to ophthalmoplegia in Weber's Syndrome?
descending motor fibers will cross at Pyramidal Decussation
Signs that Corticobulbar fibers are also affected in cases of Weber's Syndrome
contralateral paralysis of lower face and tongue
Claude's Syndrome
lesion involving CN III extends dorsally to include Red Nucleus (motor control!)

ipsilateral ophthalmoplegia
contralateral hemiparesis
contralateral paralysis of lower face/tonue

CONTRALATERAL ATAXIA (rubrospinal tract)
where do Trochlear Nerve neurons originate?
Trochlear Nucleus
located near midling of midbrain
ventral to periaqueductal grey
at level of Inferior Colliculus
pathway of trochlear nerve
originate in trochlear nucleus
pass dorsally around periaqueductal grey
CROSS
exit from dorsal surface of brainstem
continue aroudn lateral surface of crus cerebri to ventral surface of brainstem
pass btw Posterior Cerebral and Superior Cerebellar aa
travel in lateral wall of Cavernous Sinus
enter orbit via Superior Orbital Fissure
muscle innervated by trochlear nerve
Superior Oblique muscle of CONTRALTERAL eye
how to test integrity of Superior Oblique
pt looks IN (aligns the axes)

then down (S.O. activation alone)
3 causes of CN IV injury
aneurysms of Posterior & Superior Cerebellar aa

inflammation w/in Cavernous Sinus

surgical intervention in region of tentorium cerebelli
Head tilts in trochlear lesions
lesion of the trochlear NERVE (already crossed) - head tilted toward NORMAL side

lesion of the trochlear NUCLEUS - head tilited toward AFFECTED side
signs of superior oblique muscle paralysis
inability to direct eye downward, esp. when looking medially

diplopia

difficulty reading and walking down stairs

at rest, eye slightly extorted and elevated

head tilt
6 things to remember about trochlear nerve
smallest cranial nerve, but has longest intracranial pathway (~7.5cm)

only CN to exit from DORSAL surface of Brainstem

only crainal nerve that CROSSES

affected eye is directed up and out - pt has difficulty looking down, walking down stairs

pt might compensate by tilting head to side of Normal eye
where do neurons of Abducens Nerve originate?
Abducens nucleus

located within tegmentum (dorsal region) of the Pons, just below 4th ventricle

nucleus forms bump - Facial Colliculus
pathway of Abducens Nerve
from Abducens Nucleus
course ventrally through tegmentum and basal Pons

exit Brainstem at ponto-medullary junction

anterior course over apex of petrous part of temporal bone

through Cavernous Sinus

enters orbit via Superior Orbital Fissure
causes of injury to Abducens Nerve
vascular insufficiencies of Basilar artery or its Circumferential branches

compressive injury from increased intracranial pressure

middle ear infections

inflammation within Cavernous Sinus

fractures involving base of the skull
effects of tumor w/in 4th ventricle involving facial nerve and Abducens nucleus
compression of facial nerve and nucleus affects upper and lower regions of face IPSILATERAL to injury
signs of Lateral Rectus paralysis
Convergent Strabismus (eye turned inward)

inability to abduct eye

diplopia

compensation - turns head toward affected side
lesion that affects CN VI and corticospinal tract unilaterally will result in...
Middle Alternating Hemiplegia:

ipsilateral convergent strabismus

contralateral hemiplegia
If corticobulbar fibers are involved in CN VI lesion, you would see deficits in...
contralateral tongue
Where do UMNs controlling visual gaze reside?
Frontal Eye Fields
Types of Eye Movements
Slow pursuit

Saccadic

Nystagmus

Vergence
Slow Pursuit eye movements
slow (5-50x/sec)

conjugate (same direction)

movements that are used to track objects
saccadic eye movements
rapid eye movements (100-600x/second)

serve to bring objects of interest into the fovea

voluntary or reflexive

e.g.: some auditory or visual cue causes sudden shift in gaze
nystagmus
rudimentary type of saccade

2 phases - slow and fast

purpose - reset the eyes on a new target after having followed a previously movieng target that has left our view
slow phase of nystagmus
track each object until it leaves field of view
fast phase of nystagmus
rapid saccade in opposite direction to lock on to next object
direction of nystagmus is dictated by which phase?
fast phase
spontenous nystagmus
eyes rhythmically drift in one direction and then rapidly return

common indication of neurological damage
cause of spontaneous nystagmus
damage to vestibular system or one of its main central connections, such as the cerebellum
vergence (eye movement)
two eyes move in opposite directions - disconjugate

necessary to maintain fixation as target approaches the eyes

controlled by bilateral input to Oculomotor Nuclei from Supraoculomotor Nucleus
Horizontal Gaze controlled by neurons located in...
Paramedial Pontine Reticular Formation
(lateral gaze center)

region of pontine reticular formation
What controls neurons in PPRF
UMNs located in contralateral Frontal Eye Firleds of cortex
2 populations of neurons projected from PPRF
one popution - give rise to ipsilateral CN VI - innervates lateral rectus muscle

other peopulation - axons that cross midline and ascend as part of the Medial Longitudinal Fasciculus innervate motor neurons in contralateral Oculomotor Nucleus - innervate ipsilateral medial rectus
result of ipsilateral CN VI and contralateral CN III activation
simultaneous activation of ipsilateral lateral rectus muscle

contralateral medial rectus muscle

--> conjugate horizontal movement of the eyes
neurons controlling vertical gaze originate in ...
Rostral INterstitial Nucleus of MLF (riMLF)
riMLF neurons receive input from...
Frontal Eye Fields - BILATERAL
riMLF projects to the...
Oculomotor Nucleus --> superior and inferior rectus mm, inferior oblique m.

Trochlear Nucleus --> superior oblique m.
Vestibuo-ocular Reflex (VOR)
represents movement of the eyes in response to activation of the Vestibular system
normal VOR
movement of head in one direction results in compensatory movement of eyes that is equal in magnitude and opposite in direction to movement of the head

stabilizes visual world on retina during head movements
VOR is initiated by...
activation of receptors (hair follicle receptors) in

Semicircular Canals (angular acceleration) and

Otolith Organs (linear acceleration
VOR signal pathway
receptors --> vestibular ganglion/CN VIII --> vestibular nuclei --> contralateral abducens nuclei --> islateral lateral rectus & contralateral medial rectus muscles
example of VOR:

Cells in LEFT semicircular canals are activated when..
Cells in LEFT semicircular canals are activated when the head is rotated LEFT

results in activation of RIGHT abducends and compensatory rotation of the eyes to the RIGHT
mechanism underlying right-beating nystagmus
greater activity in RIGHT vestibular nuclei results in eyes drifting to the LEFT

at their limit, they snap back
6 lesions affecting eye movements
lesion of the LEFT frontal eye fields

lesion of the RIGHT PPRF

lesion of the RIGHT Abducens Nucleus

lesion of the RIGHT abducens nerve (CN VI)

lesion of the LEFT Vestibular Nuclei or CN VIII

lesion of the LEFT MLF
(ANTERIOR INTERNUCLEAR OPHTHALMOPLEGIA)
Lesion of the LEFT Frontal Eye Fields
eyes deviated tonically to the LEFT (RIGHT FEFs are in control)

No atrophy of eye muscles (LMN pathways are intact)

No diplopia (both eyes are affected equally)
Lesion fo the RIGHT PPRF
eyes deviated tonically to the LEFT (RIGHT FEFs are in control)

no atrophy of eye muscles (LMN pathways are intact)

No diplopia - both eyes are affected equally
Lesion of the RIGHT abducens nucleus
both eyes direted left (loss of direct input to ipsilateral LR and crossed input to tcontralateral oculomotor nucleus and MR.

atrophy of RIGHT LR but NOT the LEFT MR (CN III intact)

no diplopia - both eyes affected equally
Lesion of the RIGHT Abducens Nerve
RIGHT eye deviated medially (b/c imbalance w/ MR --> can't direct laterally)

atrophy of RIGHT lateral rectus

diplopia
Lesion of LEFT vestibular nuclei
RIGHT nystagmus (right side in control, drives eyes slowly left, fast saccade to the right)

LEFT staggering gait (vestibular input to left SC is reduced relateive to right side input)
Lesion of LEFT MLF, aka:
Anterior Internuclear Ophthalmoplegia
Anterior Internuclear Ophthalmoplegia
inability to turn LEFT eye past midline to the right

no atrophy of MR (oculomotor nuc and CN III intact)

diplopia when attempting to look right

nystagmus when attemptin gto look right

normal vergence (supraoculomotor nuc, oculomotor nuc and CN III intact)
Caloric test used to test ingegrity of...
Vestibular Pathways
Look up Caloric test (CP 222)
Look up Caloric test (CP 222)
Pupillary light reflex pathway
retina --> pretectum of midbrain (bilaterally) --> Edinger-Westphal N. --> ciliary ganglion --> iris sphincter
pupillary consensual response results from...
neurons in pretectum of midbrain project bilaterally onto preganglionic parasympathetic neurons in left and right Edinger-Westphahal Nuceli

ergo, loss of accomies pupillary light reflex loss
pupillary dilation originates with ...
sympathetic innervation of iris dilator muscles

pathway originates with tonic excitatory input to neurons in upper thoracic cord from neurons in hypothalamus

axons of SC neurons ascend to superior cervical ganglion --> axons follwoign internal carotid & CN III fibers into brain and orbit
loss of pupillary light responses typically indicate...
structural damage along one fo the pathways
injury at the level of the dorsal midbrain that affects the pretectal area --> what type of pupil response?
mid-sized or slightly large pupils that do not respond to light
injury to the midbrain at the level of CN III --> what pupil response?
complete loss of pupillary responses b/c of damage to descending sympathetics and parasympathetics of CN III
injury to one optic nerve results in...
complete loss of both direct and consensual response from the affected eye, but no effect on other eye
unilateral pupillary dilation is typically the result of...
injury to one of the oculomotor nerves as it exits the brainstem
most common causes of CN III compression in a comatose pt are...
aneurysm of the posterior communicating artery

or displacement of the temporal lobe by a tumor
any lesion that affects the parasympathetic componenet of CN III results in...
pupillary dilation due to the unopposed action of ascending sympathetic innervation to the iris dilator muscles

loss of accomodation
largest cranial nerve
trigeminal nerve
sensory component of trigeminal nerve conveys information concerning...
pain, temperature, touch

proprioception from:
face, forehead, mucous mb of nose, anterior 2/3 of tongue, hard & soft palates, nasal & oral cavities, muscles of mastication, teeth and portions of cranial dura
motor component of trigeminal nerve innervates...
muscles of mastication
where do primary neurons of pain, temp and touch fibers reside?
Trigeminal Ganglion

located on floor of middle cranial fossa
where do primary neurons carrying proprioception reside?
brainstem proper
peripheral processes of trigeminal primary neurons form..
Ophthalmic (V1)
Maxillary (V2)
Mandibular (V3) branches
central processes of trigeminal primary neurons terminate where?
on neurons in the Trigmeinal Nucleus of the Brainstem
trigeminal sensory nucleus extends where?
over entire length of brainstem
3 subregions of trigeminal sensory nucleus
rostral portion (rostral Pons and midbrain) - Mesencephalic Nucleus of V

central portion (Pons) - Principle/Chief Sensory Nucleus of V

caudal portion - Spinal Nucleus of V
Mesencephalic Nucleus of V

location
information handled
cell bodies located where?
Mesencephalic Nucleus of V

located adjacent to central periaqueductal grey of midbrain

nucleus handles proprioceptive information from muscles of mastication

cell bodies located within Brainstem proper
pathway from sensory receptors to Mesencephalic Nucleus of V
muscle spindles in muscles of mastication

enter brainstem via Mandibular division of CN V

central processes terminate primarily in Motor Nucleus of V, located adjacent to Principle Sensory Nucleus w/in Pons
connection between Mesencephalic Nucleus of V and Motor Nucleus of V establishes what?
stretch refelx for control of jaw position and

bite reflex that controls bite strength
Some neurons within the Motor Nucleus of V send fibers across the midline to join the ______. These fibers carry proprioception information to the contralateral _____ nucleus of the thalamus, which then relayes the information to the _____
Some neurons within the Motor Nucleus of V send fibers across the midline to join the Ventral Trigeminothalamic Tract (VTT).

These fibers carry proprioception information to the contralateral VENTRAL POSTEROMEDIAL (VPM) nucleus of the thalamus, which then relays the information to the PRIMARY SENSORY CORTEX.
Chief Sensory Nucleus of V

location
information ahndled
primary neurons found in
Chief Sensory Nucleus of V

located at mid-Pons
handles discriminatory touch, conscious proprioception and vibration information from face & oral cavity

primary neurons lcated w/in Trigeminal Ganglion
pathway of second-order neurons w/in Chief Sensory Nucleus of V
send axons across midline to form VTT

2nd-order neurons representing oral cavity --> ipsilaterally projecting Dorsal Trigeminothalamic Tract (DTT)

VTT & DTT fibers ascend to the VPM nucleus of thalamus

information relayed to ipsilateral somatosensory cortex
sensory information from the body is relayed to sensory cortex via which nucleus?
Ventral Posterolateral (VPL) nucleus
Spinal Nucleus of V

location
Spinal Nucleus of V

extends from Chief Sensory Nucleus caudlly into first 3 segments of SC - merges w/ dorsal grey matter of SC and fibers of Tract of Lissauer
Spinal Nucleus of V

information handled
pain & temperature from face, forehead, mucuous mb of nose

ANTERIOR 2/3 of TONGUE

hard & soft palates, nasal cavities, oral cavity, teeth, portions of cranial dura
Spinal Nucleus of V

primary neurons located
primary neurons located w/in Trigeminal Ganglion
second-order neurons of SPinal Nucleus of V
like Chief Sensory neurons,

send axons across midline to ascend as part of VTT

pain & temp info relayed in VPM to sensory cortex
what nucleus handles ALL pain and temperature information from the face?
Spinal Nucleus of V
Does all pain and temperature information from the face arrive at the Spinal Nucleus of V via CN V?
No

some arrives via CN VII, IX and X
pain and temperature from the region of the ear is handled primarily by...
CN VII