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9 Cards in this Set

  • Front
  • Back
Taste Transduction: SALTY
Na+ selec1ve channel
that is cons1tu1vely open.
Na+ diffuses down its
concentra1on gradient,
depolarizing the cell.
Voltage gated Ca++ and Na+
channels trigger NT release
to gustatory afferent axon
Taste Transduction: SWEET
Heterodimer T1R2+T1R3. GPCR. Activate phospholipase C--> convert PIP2 to IP3---> releases intracellular Ca2
+ storage--->activates influx of sodium and calcium
Taste Transduction: UMAMI
Heterodimer: T1R3+T1R1. GPCRActivate phospholipase C--> convert PIP2 to IP3---> releases intracellular Ca2
+ storage--->activates influx of sodium and calcium
Taste Transduction: BITTER
Homodimer: T2Rs. GPCRActivate phospholipase C--> convert PIP2 to IP3---> releases intracellular Ca2
+ storage--->activates influx of sodium and calcium
Taste Transduction: SOUR
PKDL1 (mammalian receptor for sourness (H+)
Central taste pathway
gustatory axons-->Medulla--> thalamus-->cortex
Assumptions in the experimental strategy of olfactory receptors
-ORs are GPCRs
-ORs comprise a multigene Family
-Ors exhibit restricted expression
Cell depolarization mechanism in odorant receptors
Odorant molecules bind the receptor--> G protein activates adenylate cyclase--> converts ATP into cAMP--> causes influx of NA+ and Ca++ into the cell--> intracellular Ca++ causes efflux of Cl---> membrane depolarization
One neuron, one receptor hypothesis
A single odorant gene is expressed in an olfactory sensory neuron. This identity is maintained over lifetime of cell.