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9 Cards in this Set
- Front
- Back
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Taste Transduction: SALTY
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Na+ selec1ve channel
that is cons1tu1vely open. Na+ diffuses down its concentra1on gradient, depolarizing the cell. Voltage gated Ca++ and Na+ channels trigger NT release to gustatory afferent axon |
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Taste Transduction: SWEET
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Heterodimer T1R2+T1R3. GPCR. Activate phospholipase C--> convert PIP2 to IP3---> releases intracellular Ca2
+ storage--->activates influx of sodium and calcium |
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Taste Transduction: UMAMI
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Heterodimer: T1R3+T1R1. GPCRActivate phospholipase C--> convert PIP2 to IP3---> releases intracellular Ca2
+ storage--->activates influx of sodium and calcium |
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Taste Transduction: BITTER
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Homodimer: T2Rs. GPCRActivate phospholipase C--> convert PIP2 to IP3---> releases intracellular Ca2
+ storage--->activates influx of sodium and calcium |
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Taste Transduction: SOUR
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PKDL1 (mammalian receptor for sourness (H+)
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Central taste pathway
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gustatory axons-->Medulla--> thalamus-->cortex
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Assumptions in the experimental strategy of olfactory receptors
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-ORs are GPCRs
-ORs comprise a multigene Family -Ors exhibit restricted expression |
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Cell depolarization mechanism in odorant receptors
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Odorant molecules bind the receptor--> G protein activates adenylate cyclase--> converts ATP into cAMP--> causes influx of NA+ and Ca++ into the cell--> intracellular Ca++ causes efflux of Cl---> membrane depolarization
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One neuron, one receptor hypothesis
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A single odorant gene is expressed in an olfactory sensory neuron. This identity is maintained over lifetime of cell.
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