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9 Cards in this Set

  • Front
  • Back
normal neuromuscular junction
action potential depolarizes motor neuron terminal, Ca2+ influx facilitates presynaptic release of ACh which binds to postsynaptic muscle membrane. End plate depolarization, electrical propagation, muscle contraction.
Acetylcholinesterase limits the action of ACh.
myasthenia gravis
antibodies to acetylcholine receptor block receptor sites, increased receptor degradation and turnover, clinical weakness
Lambert-Eaton myasthenic syndrome
presumed immunologic attack on presynaptic calcium channels which impairs release of ACh, usually related to underlying cancer
viral infection primarily of lower motor neurons
spinal muscular atrophy
infantile = Werdnig-Hoffman
childhood and adult = Kugelberg-Welander
adult benign focal amyotrophy involves one limb, best prognosis
all exhibit lower motor neuron signs
primary lateral sclerosis
involves corticospinal tracts, upper motor neuron signs. no structural or metabolic cause known.
progressive bulbar palsy
involves brain stem motor nuclei
pseudobulbar palsy
involves corticobulbar tracts, upper motor neuron signs
amyotrophic lateral sclerosis (ALS, Lou Gehrig disease)
degeneration of corticospinal and corticobulbar tracts