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34 Cards in this Set
- Front
- Back
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RLS of heme symthesis
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ALA synthase
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structure of HbH
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4B
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structure of Hb Barts
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y4
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disease a/w HbH
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a thal
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disease a/w Hb Barts
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hydrops fetalis
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features of parkinsons
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tremor
rigidity akinesia postural instability |
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px exposed to MPTP, what neurotransmitter is he def in
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DA
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impact on movement by globus pallidum internal
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inhibits
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impact on movement by subthalamic nucleus
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inhibits
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impact on movement by substantia nigra pars compacta
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stimulates
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what is a/w hyperkinesia
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huntingtons
hemiballismus chorea athetosis |
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what is a/w hyperreflexia
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UMN lesion
low Ca Low Mg |
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what is damaged in huntingtons
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cuadate nucleus
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neurotransmitters altered in huntingtoins
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decreased GABA and ACh
increased DA |
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what is damage din hemiballismus
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subthalamus
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what is seen histologically in parkinsons
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lewy bodies
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what are lewy bodies
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a-synuclein intracellular inclusions
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what other disease can present with parkinson like symptoms
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wilsons
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what does wilsons damage that causes pakrinsons like symptoms
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putamen
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Rx for huntingtons
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haloperidol
reserpine tetrabenazine |
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what causes neuronal death in huntintons
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NMDA-R binding
glutamate toxicity |
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how can you surgically treat parkinsons
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lesion the GPe or the subthalamic nucelus
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what arteries supply the basal ganglia
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lenticulostriate
branch of MCA |
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what ergots are used to Rx parkinsons
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bromocriptine
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why are ergots not used as often as nonergots
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ergots cause vasoconstriction
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what nonergots are used to Rc parkinsons
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pramipexole
ropinirole |
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what antiviral can be used to Rx parkinsosn
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amantadine
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MOA of selegiline
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MOA type B inhibitor
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MOA used to treat parkinsons
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selegiline
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COMT inhibitors used to Rx parkinsons
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entacapone
tolcapone |
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what anticholinergics can be used to Rx parkinsons
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benztropine
trihexiphenedyl |
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when shouldnt L-dopa be given
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px with melanoma
or taking MAOI |
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what shouldnt be taken with L-dopa
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vitamine supplements
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MOA of reserpine and tetrabenazine
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depletes amines
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