Neuro 4 Antiparkinson Drugs

Front 1

Biogenic amines=

Back 1

Amphetamine

Front 2

This was given for excess salivation and decreased cholinergic activity and improved PD?

Back 2

Atropine-anticholinergic

Front 3

What drugs cause Parkinson effects?

Back 3

Drugs that deplete dopamine

Front 4

What does MPTP do?

Back 4

Destroy NMDA receptors

Front 5

What does reserpine do?

Back 5

Deplete dopamine

Front 6

What do cholorpromazine and haloperidol do

Back 6

Block dopamine receptors

Front 7

PD relationship with genetics?
What can cause PD?

Back 7

Minor Genetic relationship. Head injury, pesticides, well water

Front 8

The intrinsic molecule in the striatum is?

Back 8

ACh

Front 9

Theauraputic model for PD is to either ? or??

Back 9

Suppress ACh with anticholinestrases and Agment Dopamine receptors

Front 10

What do dopaminergic drugs work on?

Back 10

Work on D2 receptors

Front 11

For drug induced extrapyramidal effects what isn't effective? What must you give to improve them?

Back 11

Giving more dopamine, so you have to give anticholinestrases

Front 12

What is the rate limiting step of dopamine synthesis--

Back 12

Tyrosine hydroxylase

Front 13

Why cant you give dopamine?

Back 13

It cannot cross BBB

Front 14

What do you give in order to bypass bottleneck?

Back 14

DOPA

Front 15

Therapy given in low doses at small intervals with a 70% respndent rate. Good results usually 5 years but has non responsive periods. This is?

Back 15

Levodopa

Front 16

Triggers the Chemorecepoter trigger zone (nausea, vomitting) cause orthostatic hypotension, abnormal movements, choreiform or faciolingual problems?

Back 16

Levodopa

Front 17

Can cause psychiatric/behavioral problems in about 15% of patients as well as chorea and dystonia?

Back 17

Levodopa

Front 18

L-dopa is converted to dopamine before it crosses the BBB, how do you prevent this? this limits what happening in the peripheria?

Back 18

Carbidopa, bad side effects in the peripheral and it lowers the amount of dosages of L-dopa

Front 19

what are the benefits of L-dopa and carbidopa being in the same pill?

Back 19

Less N/V cheaper cost, Reduce the effective dose and increase the time it takes to be effective

Front 20

What can be the problems with L-dopa and carbadopa?

Back 20

Orthostatic hypotension not helped, adverse mental effects ooccur earlier

Front 21

This is the combination of Levodopa and carbadopa?

Back 21

Sinemet

Front 22

What are COMT inhibitors similar to? This prevents what?

Back 22

Carbidopa, prevents converstion of dopa to 3-O-methyl dopa peripherally. Increases half life and enhancing entry to CNS

Front 23

Pramipexol and Ropinirole are what? What receptors do they work on

Back 23

Dopaminergic agonists for D2 and D3 receptors

Front 24

What do dopaminergic agonists approved for? They also what reach what levels faster/?

Back 24

Restless leg syndrome
therapeutic

Front 25

Rotigotine is what type of agonist? What type of side effects?

Back 25

D3/D2/D1 dopamine agonist
N/V, headache poor impuls control

Front 26

Antiviral agent-NMDA antagonist, mechanism isnt known, antagonize the effects of adenosine at adenosince A2a receptors?

Back 26

Amatidine

Front 27

Recepotrs that inhibit D2 receptor function. Treat with which drug?

Back 27

Adenosine A2a, amatidine

Front 28

An MAO-B inhibitor that preserves dopamine in the basal ganglia, allows for lower doses of L-dopa

Back 28

Selegiline

Front 29

Another MOA-B inhibitor that may not be as selective for dopamine, don't use with antidepresents that raise serotonine?

Back 29

Rasagiline

Front 30

Don't give this drug with meperidine, tramadol, methadone, or older tricyclic antidepressants?

Back 30

Selegiline

Front 31

This drug is giveen for advanced Parkinson patients with significant 'off' periods?

Back 31

Apomorphine

Front 32

Give when PD is induced by drugs?

Back 32

Anticholinergic agesnts

Front 33

For drug induced PD you cannot do anything on the dopamine side what is the only side you can effect?

Back 33

The cholinergic side. Give anticholinergics

Front 34

Trihexyphenidyl, benztropine, antihistamines, diphenhydramine are all?

Back 34

Anticholinergic agents

Front 35

Anticholinergics result in what bad side effects?

Back 35

Dry mouth and blurry vision can cause heat stroke

Front 36

New major control of PD by stimulation of the subthalmic nucleus?

Back 36

Microstimulators.

Front 37

The first line of PD treatment is?
Second line is?

Back 37

Dopaminergic agents
Anticholinestrase agents