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12 Cards in this Set
- Front
- Back
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Describe the differences beween mypathic, neurpathic, and neurogenic disease
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1. myopathic=intrinsic abnormality to muscle 2. Neuropathic=abnormality in peripheral n. 3. Neurogenic=interruption fo normal innervation of muscle, abnormality in the muscle is secondary
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Describe the clinical symptoms of DMD
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waddling or lurching gait, abnormal walk/run, mslce wasting, weakness, lordosis, skeletal deformiteis, contractures, high blood CK
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what is the cause of DMD
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lack of dystrophin gene on X chromosome, codes for dystrophin whic hanchors actin in cytoskeletal membrane and stablizes the sarcolemma. W/o dystrophin, the sarcolemma membrane is unstable and there is shearing/ tearing of teh membrane, influx of Ca, and necrosis of the muscle fiber
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What is the cause of myasthenia gravis
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Autoimmune disorder that impairs transmission at the NMJ, antibodies made acgainst nicotinic Ach receptor and block Ach function, triggers internalization,, thymus gland implicated
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what are the sxs of myasthenia gravis
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muslce power is reduced, fatigue due to depleted Ach, weakness in cranial muscles, eyelins, eye muscles, oralpharyngeal muscles etc. limbs can be affected, sxs vary with time of day
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What is the Tx for myasthenia gravis
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ACHase inhibitors, plasmaphoresis, thymectomy
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What are the clnical sxs of LMN disorder
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atrophy, fasciculations, decreased lone, loss of reflexes (WWW weak, wasted, wiggling)
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What are the sxs of upper motor neuron disorder
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spasticity, overactive tendon reflexes, Babinski sign (No atrophy)
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Describe ALS
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degreneration of both U and LMN, muscle atrophy, sclerosis of SC due to proliferation of astrocytes, degeneration of corticospinal tracts
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what are the sxs of ALS
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combined UMN (spasticity, hyperreflexia, babinski) and LMN (wekaness, atrophy, fasciculations, twitching) signs, other probelms with swallowing, speech, pseudobulbar affect (note eyes, bladder, bowel ok)
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What are the typical sxs of neuropathy
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"glove and stocking" sensory loss, Lmn type weakness
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Describe GBS
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acute inflammaotry dymelinating polyneuropathy, inflamaotry cells and antibodies attack myelin sheath around peripheral nerves, Tx with plasmaphoresis
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