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15 Cards in this Set
- Front
- Back
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3 Parts of Basal Ganglia
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Caudate Nucleus, Putamen, Globus Pallidus
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Function of the Striatal (Extrapyramidal) Motor System
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Initiation and Execution of Somatic Motor Activity (Willed Movement), Postural and Reflex Motor Activity
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Striatum Consists of:
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Caudate Nucleus and Putamen
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Striatal Motor System consists of:
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Neocortex, Striatum, Globus Pallidus, Subthalamic Nucleus, Substantia Nigra, Thalamus
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Parkinson's affects what region
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Substantia Nigra and its Projections to the Striatum
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Results of Parkinson's Disease
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Depletion of DA and Loss of Melanin-containing Dopaminergic neurons
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Histological sign of Parkinson's
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Lewy Bodies in the Melanin-containing neurons of the Substantia Nigra
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Cause of Drug-Induced Parkinson's
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Methyl-Phenyl-Tetra-Hydropyridine (MPTP), an Analog of MEPERIDINE (Demerol)
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Genetics of Huntington's (Chorea)
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Autosomal Dominant, Single Gene Defect on Chromosome 4
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Pathogenesis of Huntington's
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Degeneration of Cholinergic and GABA-ergic neurons of Striatum
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Neurotransmitter released in large amounts in Huntington's and Pathogenesis
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Glutamate (excitatory), NMDA Receptor-->influx of Ca+ = cell death
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MCC overall cause of Chorea, seen in Girls after Rheumatic Fever
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Sydenham's Chorea (St. Vitus' Dance)
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Wilson's Disease Genetics
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Autosomal Recessive, Chromosome 13
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Signs of Wilson's
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Chorea, WING-BEATING TREMOR, rigidity, Kayser-Fleischer Rings, Cirrhosis, Psych
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Tx of Wilson's
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Penicillamine
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