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8 Cards in this Set
- Front
- Back
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2 classes of cholinergic receptors?
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nicotinic and muscarinic
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What is the precursor for catecholamines?
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Tyrosine
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What is the rate limiting step in the synthesis of dopamine and norepinephrine?
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Tyrosine hydroxylase - Converts tyrosine to DOPA
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What is the pathway to epinephrine synthesis, starting with Tyrosine?
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1. Tyrosine - tyrosine hydroxylase
2. DOPA 3. Dopamine 4. Norepinephrine 5. Epinephrine |
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What happens to dopamine in the cleft?
What about dopamine in the extracellular space? |
It is uptaken by MAO and converted to DOPAC
Extracellularly - it gets converted to HVA |
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What is the function of COMT?
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To convert extracellular dopamine to HVA.
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What are the DA receptors and where are they located?
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Found on presynaptic terminals called autoreceptors; and also on postsynaptic somatodendritic processes
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What are the two families of postsynaptic DA receptors?
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D1 receptors - activate adenylyl cyclase
D2 receptors - inhibit or have no effect on adenylyl cyclase |
