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17 Cards in this Set
- Front
- Back
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cranial neural crest cells give rise to what?
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cartilage, bone and connective tissue of the face, teeth, jaw and middle ear bone
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trunk neural crest cells give rise to what? early migratory? those that remain in the sclerotomes? later migrating?
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early- go anterior somatic route, sympatheric ganglia, adrenal medulla, nerve clusters of aorta
remain- dorsal root anglia with sensory neurons later- melanocytes |
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vagal and sacral n.c. are ?
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parasympathetic of the gut
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cardiac n.c. are?
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melanocytes, neuraons, cartilage and connective tissue of cardiac lineage
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two pathways of trunk neural crest cells?
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1. through the anterior segment of the somite (ventral pathway)
2. go the dorsal lateral route between the epidermis and the dermis |
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the ventral pathway trunk n.c.becomes what?
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sensory sympathetic neurons, adrenomedullary cells, Schwann cells
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the dorsalateral pathway trunk n.c. become what?
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melanocytes- skin, hair
(inhibit this pathway get albinos) |
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do ephrins repel or attract n.c.? and where are they expressed?
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they repel and are expressed in the posterior region of the schlerotome
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what on n.c. recognizes ephrins? and what do they do in response?
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they have Eph receptors, and go away from ephrins
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ephrins and eph receptors causes what patterning?
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the patterning of the peripheral nervous system (PNS)
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ephrin has the same affect on n.c. cells on what?
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motor neurons
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cranial NCs go where and from where
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from rhombomeres in streams to the pharengeal arches and frontonasal process
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whats genes are important to the pharangeal arch development in arches 1/2 that leads to jaw bone development and middle ear?
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hox genes (Hox a2)- from arch 2
Fgf8 and BMPs- in arch 1 that inhibits hox's |
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what part of the cranial region is not from neural crest cells?
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the back of the skull- parietal bone
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what genes are important to cardiac crest cell migration?
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Pax3
w/o get para thyroid defects |
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what are cranial placodes
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thickenings in the cranial region of ectoderm, they form sensory neurons
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how do the placodoes dev? genes involved
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Fgfs and wnts upregulate expression of Pax3
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