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3 Cards in this Set
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Nervous System- Non-opioid analgesics by Schriefer
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Nervous System- Non-opioid analgesics by Schriefer
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what is the prototype?
what is the mechanism of action? how do NSAIDs relieve fever? |
Although chemically diverse, these agents appear to act by a similar mechanism and have similar pharmacologic effects. Aspirin will serve as the prototype for this class of drugs.
Mechanism of action – inhibition of synthesis of prostaglandins (PG’s) by inhibiting cyclooxygenase. COX1 is a constitutive enzyme – inhibition of this leads to side effects such as gastric ulcer. COX2 is an inducible enzyme (induced by inflammation) – inhibition of this leads to beneficial effects. Relationship of prostaglandins to pain – PG’s sensitize pain receptors to mechanical and chemical stimulation Relationship to fever – PG’s in hypothalamus mediate increase in body temperature |
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Ketoralac (Toradol) is the only NSAID available for what?
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parenteral use.
NSAID which is useful for treatment of moderate to severe pain. Reported to be as effective as morphine for moderate pain. Available in oral, IM and IV form. used in conjunction with morphine for kidney stones so you don't have to give as much morphine. Analgesic rebound in chronic headache sufferers |
