Nervous System- Intro To Neuropharm By Schriefer

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Nervous System- Intro to Neuropharm by Schriefer

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Nervous System- Intro to Neuropharm by Schriefer

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Name the excitatory AChs

Name the inhibitory ACHs

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Excite: M1, M3, M5, Nicotonic

Inhibit: M2, M4

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Is GABA excitatory or inhibitory?

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btw it's an amino acid.

it's the MAJOR inhibitory NT in the CNS.

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Is Glutamate excitatory or inhibitory?

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btw it's an amino acid.

it's the Major Excitatory NT in the CNS.

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Dopamine is excitatory or inhibitory?

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Inhibitory. btw it's a biogenic amine

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Norepinephrine is excitatory and inhibitory. Which ones are which?

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Excite: alpha-1, beta-1

Inhibit: alpha-2, beta-2

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Serotonin is excitatory or inhibitory?

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excite: 5-HT2, 5-HT3, 5-HT4

inhibitory: 5-HT1

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Opioid peptides are excitatory or inhibitory?

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inhibitory.

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Ionotropic receptors are associated with...

Metabotropic receptors are couple with ...

and their relative speeds.

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ionotropic receptors (also known as ligand-gated channels) are ass'd with ion channels, and change ionic conductance. they mediate fast, short effects.

metabotropic receptors are coupled with enzymes via G-proteins and other intermediates. Mediate slow, long effects.

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retrograde signaling. name a NT that works this way.

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stimulation of post-synaptic neurons causes them to release transmitters that influcence pre-synaptic neurons. endocannabioids work this way.

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characteristics which regulate diffusion of substances through capillaries are...

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1. molecular weight
2. lipid solubility (higher is faster)
3. ionization at physiological pH

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name things that drugs can do

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cognitive processing (disorders are delirium)
memory (disorders are dementia)
emotional processing (anxiety, mood disorders, schizophrenia)
sensory processing (sleep disorders, chronic pain)
motor processing (parkinson's, demyelination dz)