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21 Cards in this Set
- Front
- Back
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M1
- Locations - Result of Ligand Binding |
CNS neurons
some Symp. post-gang neurons some presynaptic sites Formation of IP3 and DAG, increased intracellular Ca |
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M2
- Locations - Result of Ligand Binding |
Myocardium
smooth muscle some presynaptic sites CNS neurons Opening of K channels inhibition of adenyl cyclase |
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M3
- Locations - Result of Ligand Binding |
Exocrine glands
vessels (smooth muscle & endothelium) CNS neurons Like M1: Formation of IP3 & DAG increased intracellular Ca |
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M4
- Locations - Result of Ligand Binding |
CNS neurons
possibly vagal nerve endings Like M2: Opening of K channels inhibition of adenyl cyclase |
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M5
- Locations - Result of Ligand Binding |
vascular endothelium, especially cerebral vessels
CNS neurons Like M1: formation of IP3 & DAG increased intracellular Ca |
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N(N)
- Locations - Result of Ligand Binding |
postganglionic neurons
some presynaptic cholinergic terminals opening of Na, K channels depolarization |
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N(M)
- Locations - Result of Ligand Binding |
skeletal muscle neuromuscular end plates
Opening of Na, K channels depolarization |
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What three neurotransmitters are catecholamines?
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NE (the principal transmitter of most symp. post-gang)
DA Epinephrine |
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Alpha1
- Locations - Result of Ligand Binding |
postsynaptic effector cells - esp. smooth muscle
Formationof IP3 & DAG increased intracellular Ca |
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Alpha2
- Locations - Result of Ligand Binding |
presynaptic adrenergic nerve terminals
juxtaglomerular apparatus of renal tubules ciliary body epithelium stimulation of adenylyl cyclase decreased cAMP |
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Beta1
- Locations - Result of Ligand Binding |
postsynaptic effector cells - esp. heart, lipocytes, brain
presynaptic adrenergic & cholinergic nerve terminals juxtaglomerular apparatus of renal tubules ciliary body epithelium stimulation of adenylyl cyclase increased cAMP |
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Beta2
- Locations - Result of Ligand Binding |
postsynaptic effector cells - esp. smooth & cardiac muscle
stimulation of adenylyl cyclase increased cAMP activates cardiac G1 under some conditions |
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Beta3
- Locations - Result of Ligand Binding |
postsynaptic effector cells - esp. lipocytes
heart stimulation of adenylyl cyclase increased cAMP |
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α1a
- tissue localization - subtype dominant effects |
heart, liver, cerebellum, cerebral cortex,
prostate, lung, vas deferens, blood vessels contraction of smooth muscle including vasoconstriction in numerous arteries and veins |
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α1b
- tissue localization - subtype dominant effects |
kidney, spleen, lung,
cerebral cortex most abundant subtype in heart; with α1a promotes cardiac growth and structure |
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α1d
- tissue localization - subtype dominant effects |
platelets, cerebral cortex, prostate,
hippocampus, aorta, coronary arteries vasoconstriction in aorta & coronary atrteries |
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α2a
- tissue localization - subtype dominant effects |
platelets, cerebral cortex, locus ceruleus,
spinal cord, sympathetic neurons, autonomic ganglia inhibitory autoreceptor in symp nerve vericosities mediating α2 agonist-induced antinociception, sedation, hypotension, and hypothermia |
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antinociception
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reducing sensitivity to painful stimuli
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α2b
- tissue localization - subtype dominant effects |
liver, kidney, blood vessels
mediating α2 induced vasoconstriction |
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α2c
- tissue localization - subtype dominant effects |
cerebral cortex
modulating DA neurotransmission inhibitory receptor on adrenal medulla |
