Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
64 Cards in this Set
- Front
- Back
are neurons are..
|
interconnected
|
|
somatic (voluntary) nervous system (SNS)
|
cutaneuous and special sensory receptors to the cns
-motor neurons to skeletal muscle tissue |
|
ion channels can be.. (4)
|
1. leakage
2. ligand 3. voltage 4. mechanical |
|
neurons are electrically excitable due to...
|
the voltage difference across their membrane
|
|
a flow of ions occurs through
|
ion channels in the cell membrane
|
|
potential difference
|
difference of electricity between inside of cell and outside of cell. resting potential: 17 millivoltage
|
|
inside of cell is ___, compared to the ______
|
negative, outside
|
|
where do you fine leakage ion channels?
|
in the heart
i.e. pacemaker |
|
example of a ligand
|
neurotransmittor binds to the receptor and the ion channels then are opened and na flows in
|
|
voltage channel opens when..
|
you change the resting potential
|
|
mechanical ion channel example
|
when it is very dark and someone slaps your eyes, you see sparks/stars
|
|
negative ions where and positive ions where?
|
neg = inside, pos = outside
|
|
hyperpolarization
|
membrane has become more negative
|
|
depolarization
|
membrane has become more positive
|
|
value of resting potential
|
-70 mV
|
|
action potential (AP)
|
a sequence of rapidly occurring events that decrease and eventually reverse the membrane potential (depolarization) and the restore it to the resting state (repolarization)
|
|
during an action potential voltage-gated ____ & ____ open in in sequence
|
NA+ and K+ channels
|
|
all-or-none principle
|
if a stimulus reaches a threshold, the action potential is always the same
|
|
a stronger stimulus will....
|
NOT cause a larger impulse
|
|
step by step of an action potential
|
1. whenever a stimulus takes place to membrane, sodium channels open
2. sodium diffuses inside the cell 3. charge inside the cell changes, becomes more positive (depolarization) (+30 or +40) 4. potassium channels open, K+ goes outside the cell 5. charge goes down back to around -70 6. NA+ channels close but K+ channels are still open, so more K+ is lost, so inside of cell becomes even more negative. 7. to bring everything back to normal, pumps pump out Na+ and takes back in K+ |
|
nerve impulse
|
propogation of an action potential
|
|
depolarization
|
inversion of resting potential (-70 to +4 mV), due to Na+ influx
|
|
1st repolarization
|
(+40 to -70 mV) due to the efflux of K+
|
|
refractory period
|
period when a neuron cannot respond to any stimulus
|
|
absolute refractory period
|
even very strong stimulus will not begin another AP
-inactivated Na+ channels |
|
relative refractory period
|
a suprathreshold stimulus will be able to start an AP
-K+ channels are still open, but Na+ channels have closed |
|
3 important parts of chemical synapse
|
1. pre-synaptic bulb
2. synaptic cleft -gap b/w 2 membrane 3. post-synaptic membrane- has ligand-type ion channels |
|
continuous conduction
|
(unmyelinated fibers)
-step-by-step depolarization of each portion of the length of the axolemma, slow about 25-35 m/sec |
|
saltatory conduction
|
-depolarization only at nodes of ranvier where there is a high density of voltage-gated ion channels
-currently carried by ions flows through extracellular fluid from node to node- fast: 110-130 m/sec |
|
speed determined by
|
amount of myeliniation (more- faster), the axon diameter (bigger axon- travels faster), temperature (hotter-colder)
|
|
why is it important to have hyperpolarization?
|
because it ensures that the action potential only travels one direction and does not go backwards
|
|
depolarization postsynaptic potential (EPSP)
|
-results from the opening of ligand-gated Na+ channels
-the postsynaptic cell is more likely to reach threshhold |
|
inhibitory postsynaptic potential (IPSP)
|
-results from the opening of ligand-gated Cl- or K+
-causes the postsynaptic cell to become more negative or hyperpolarized -the postsynaptic cell is less likely to reach threshold |
|
GABA
|
gamma amino buturic acid- important in pain neurons
(shoes too tight) -when you think about shoes it hurts, when you dont think about shoes, it doesn't hurt |
|
some pain meds...
|
hyperpolarize the postynaptic membrane
|
|
example of an IPSP
|
gaba neurons
|
|
neurotransmitter effects can be modified
|
-receptor site can be blocked or activated
-removal can be stimulated or blocked -release can be blocked or stimulated -synthesis can be stimulated or inhibited |
|
agonist
|
anything that enhances a transmitters effects
|
|
antagonist
|
anything that blocks the action of a neurotransmitter
|
|
limited ability for regeneration (repair)
|
-PNS: can repair damaged dendrites or axons
-CNS: no repairs are possible |
|
spinal cord protective structures
|
vertebral column and the meninges provide physical stability
|
|
layers of spinal cord
|
1. dura mater
2. arachnoid 3. pia mater |
|
spaces of the spinal cord
|
epidural space, subdural space (below dural space) and subarachnoid (below arachnoid layer) space
|
|
conus medullaris
|
tapering of the spinal cord
|
|
cauda equina
|
nerves at the end of the spinal cord; look like a horse's tail
|
|
filum terminale
|
connective tissue that holds the spinal cord in place, all the way to the sacrum. located in the middle of the cauda equina
|
|
ganglion
|
accumulation of cell bodies of neurons
|
|
# of pairs of spinal nerves
|
31
|
|
color of nonmylienated nerves
|
grey
|
|
color of myleniated nerves
|
white
|
|
white matter location in brain
|
in core
|
|
sulcus
|
depression in the nervous tissue
|
|
fissure
|
BIG depression
|
|
central canal
|
space continues with ventricles of the brain.. has cerebral spinal fluid
|
|
where can you find interneurons?
|
in grey matter of the brain. are sensory neurons.
|
|
spinal neves are _____ nerves
|
mixed
are sympathetic, somatic and parasympathetic |
|
spinal nerves names
|
c1-c8
t1-t12 l1-l5 s1-s5 & coccygeal |
|
5 plexus
|
cervical, brachial, lumbar, sacral, coccygeal
|
|
plexus
|
a network of nerves
|
|
rami
|
spinal nerve branches
|
|
reflex
|
an automatic, sudden, involuntary response to stimulus
|
|
reflex arc includes
|
a. sensory receptor
b. sensory neuron c. integrating center (interneuron) d. motor neuron e. effector |
|
reflex arc
|
pathway followed by a nerve impulses that produce a reflex
|
|
stretch reflex
|
causes contraction of a skeletal muscle in response to stretching of the muscle
-monosynaptic reflex |