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64 Cards in this Set

  • Front
  • Back
are neurons are..
interconnected
somatic (voluntary) nervous system (SNS)
cutaneuous and special sensory receptors to the cns
-motor neurons to skeletal muscle tissue
ion channels can be.. (4)
1. leakage
2. ligand
3. voltage
4. mechanical
neurons are electrically excitable due to...
the voltage difference across their membrane
a flow of ions occurs through
ion channels in the cell membrane
potential difference
difference of electricity between inside of cell and outside of cell. resting potential: 17 millivoltage
inside of cell is ___, compared to the ______
negative, outside
where do you fine leakage ion channels?
in the heart
i.e. pacemaker
example of a ligand
neurotransmittor binds to the receptor and the ion channels then are opened and na flows in
voltage channel opens when..
you change the resting potential
mechanical ion channel example
when it is very dark and someone slaps your eyes, you see sparks/stars
negative ions where and positive ions where?
neg = inside, pos = outside
hyperpolarization
membrane has become more negative
depolarization
membrane has become more positive
value of resting potential
-70 mV
action potential (AP)
a sequence of rapidly occurring events that decrease and eventually reverse the membrane potential (depolarization) and the restore it to the resting state (repolarization)
during an action potential voltage-gated ____ & ____ open in in sequence
NA+ and K+ channels
all-or-none principle
if a stimulus reaches a threshold, the action potential is always the same
a stronger stimulus will....
NOT cause a larger impulse
step by step of an action potential
1. whenever a stimulus takes place to membrane, sodium channels open
2. sodium diffuses inside the cell
3. charge inside the cell changes, becomes more positive (depolarization) (+30 or +40)
4. potassium channels open, K+ goes outside the cell
5. charge goes down back to around -70
6. NA+ channels close but K+ channels are still open, so more K+ is lost, so inside of cell becomes even more negative.
7. to bring everything back to normal, pumps pump out Na+ and takes back in K+
nerve impulse
propogation of an action potential
depolarization
inversion of resting potential (-70 to +4 mV), due to Na+ influx
1st repolarization
(+40 to -70 mV) due to the efflux of K+
refractory period
period when a neuron cannot respond to any stimulus
absolute refractory period
even very strong stimulus will not begin another AP
-inactivated Na+ channels
relative refractory period
a suprathreshold stimulus will be able to start an AP
-K+ channels are still open, but Na+ channels have closed
3 important parts of chemical synapse
1. pre-synaptic bulb
2. synaptic cleft -gap b/w 2 membrane
3. post-synaptic membrane- has ligand-type ion channels
continuous conduction
(unmyelinated fibers)
-step-by-step depolarization of each portion of the length of the axolemma, slow about 25-35 m/sec
saltatory conduction
-depolarization only at nodes of ranvier where there is a high density of voltage-gated ion channels
-currently carried by ions flows through extracellular fluid from node to node- fast: 110-130 m/sec
speed determined by
amount of myeliniation (more- faster), the axon diameter (bigger axon- travels faster), temperature (hotter-colder)
why is it important to have hyperpolarization?
because it ensures that the action potential only travels one direction and does not go backwards
depolarization postsynaptic potential (EPSP)
-results from the opening of ligand-gated Na+ channels
-the postsynaptic cell is more likely to reach threshhold
inhibitory postsynaptic potential (IPSP)
-results from the opening of ligand-gated Cl- or K+
-causes the postsynaptic cell to become more negative or hyperpolarized
-the postsynaptic cell is less likely to reach threshold
GABA
gamma amino buturic acid- important in pain neurons
(shoes too tight)
-when you think about shoes it hurts, when you dont think about shoes, it doesn't hurt
some pain meds...
hyperpolarize the postynaptic membrane
example of an IPSP
gaba neurons
neurotransmitter effects can be modified
-receptor site can be blocked or activated
-removal can be stimulated or blocked
-release can be blocked or stimulated
-synthesis can be stimulated or inhibited
agonist
anything that enhances a transmitters effects
antagonist
anything that blocks the action of a neurotransmitter
limited ability for regeneration (repair)
-PNS: can repair damaged dendrites or axons
-CNS: no repairs are possible
spinal cord protective structures
vertebral column and the meninges provide physical stability
layers of spinal cord
1. dura mater
2. arachnoid
3. pia mater
spaces of the spinal cord
epidural space, subdural space (below dural space) and subarachnoid (below arachnoid layer) space
conus medullaris
tapering of the spinal cord
cauda equina
nerves at the end of the spinal cord; look like a horse's tail
filum terminale
connective tissue that holds the spinal cord in place, all the way to the sacrum. located in the middle of the cauda equina
ganglion
accumulation of cell bodies of neurons
# of pairs of spinal nerves
31
color of nonmylienated nerves
grey
color of myleniated nerves
white
white matter location in brain
in core
sulcus
depression in the nervous tissue
fissure
BIG depression
central canal
space continues with ventricles of the brain.. has cerebral spinal fluid
where can you find interneurons?
in grey matter of the brain. are sensory neurons.
spinal neves are _____ nerves
mixed
are sympathetic, somatic and parasympathetic
spinal nerves names
c1-c8
t1-t12
l1-l5
s1-s5
& coccygeal
5 plexus
cervical, brachial, lumbar, sacral, coccygeal
plexus
a network of nerves
rami
spinal nerve branches
reflex
an automatic, sudden, involuntary response to stimulus
reflex arc includes
a. sensory receptor
b. sensory neuron
c. integrating center (interneuron)
d. motor neuron
e. effector
reflex arc
pathway followed by a nerve impulses that produce a reflex
stretch reflex
causes contraction of a skeletal muscle in response to stretching of the muscle
-monosynaptic reflex