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3 Cards in this Set

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Reasons for neuropathy

Physical trauma


Systemic disease i.e. diabetes


Nutritional deficiency i.e. vit b12


Blood supply obstruction i.e. vasculitis, arteriosclerosis


Infection i.e. HIV


Side effects of certain anti cancer drugs

Types of nerve injury

Neuropraxia (disruption of blood supply due to compression)


Axonotmesis (axon itself is disrupted,wallerian degeneration)


Neuronotmesis(neuron and sorrounding tissue)

Ascending order of increasing severity

Nerve regeneration

Injury signal promote RAG (regeneration associated gene)


Dedifferentiation of Schwann cells promote (NGF) neurogenic growth factor


Schwann cells and macrophage release (TGF BETA) transforming growth factor