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75 Cards in this Set

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symptomes of nephritic syndrome
hematuria, hypertension, oliguria, azotemia.

Inflammation
6 types of Nephritic Syndrome
Acute poststreptococcal glomerulonephritis

Rapidly progressive (crescentic) Glomerulonephritis

Goodpasture’s syndrome (type II hypersensitivity)

Membranoproliferative glomerulonephritis

IgA nephropathy (Berger’s disease)

Alport’s syndrome
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"
Acute poststreptococcal glomerulonephritis

(acute proliferative glomerulonephritis)
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"

EM: subepithelial humps

IF granular pattern

Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
EM: subepithelial humps
Acute poststreptococcal glomerulonephritis

(acute proliferative glomerulonephritis)
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"

EM: subepithelial humps

IF granular pattern

Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
IF: granular pattern

"lumpy-bumpy" immunofluorescence (extremely coarse granular immunofluorescence for IgG or C3)
Acute poststreptococcal glomerulonephritis

Membranous Glomerulonephritis also has a granular IF pattern
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"

EM: subepithelial humps

IF granular pattern

Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
Acute poststreptococcal glomerulonephritis

(acute proliferative glomerulonephritis)
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"

EM: subepithelial humps

IF granular pattern

Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
Labs: urinary red cells and red cell casts, azotemia, decreased serum C3, and increased titers of antistrepotococcal antibodies (antistreptolysin O [ASO]), antiDNAase B, and anticationic proteinase as evidence of recent streptococcal infection.
Acute poststreptococcal glomerulonephritis
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"

EM: subepithelial humps

IF granular pattern

Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
Acute poststreptococcal glomerulonephritis labs
Labs: urinary red cells and red cell casts, azotemia, decreased serum C3, and increased titers of antistrepotococcal antibodies (antistreptolysin O [ASO]), antiDNAase B, and anticationic proteinase as evidence of recent streptococcal infection.
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"

EM: subepithelial humps

IF granular pattern

Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
LM and IF: Crescent moon shape
Rapidly progressive (crescentic) Glomerulonephritis
LM and IF: Crescent moon shape

Rapid course to renal failure from one of many causes
Rapid course to renal failure from one of many causes
Rapidly progressive (crescentic) Glomerulonephritis
LM and IF: Crescent moon shape

Rapid course to renal failure from one of many causes
IF: linear pattern
Goodpasture’s syndrome (type II hypersensitivity)

Linear pattern b/c of anti-GBM antibodies
IF: linear pattern. Linear pattern b/c of anti-GBM antibodies

Hemoptysis, hematuria
Hemoptysis, hematuria
Goodpasture’s syndrome (type II hypersensitivity)
IF: linear pattern. Linear pattern b/c of anti-GBM antibodies

Hemoptysis, hematuria
EM: subendothelial humps, "tram track" - double contour
Membranoproliferative glomerulonephritis
EM: subendothelial humps, "tram track" - double contour

Slowly progresses to renal failure
Slowly progresses to renal failure
Membranoproliferative glomerulonephritis
EM: subendothelial humps, "tram track" - double contour

Slowly progresses to renal failure
IF and EM: mesangial deposits of IgA.
IgA nephropathy (Berger’s disease)––
Mild disease, often post-infectious
IgA nephropathy (Berger’s disease)
split basement membrane
Alport’s syndrome
split basement membrane

Collagen IV mutation. Nerve deafness and ocular disorders
Collagen IV mutation. Nerve deafness and ocular disorders
Alport’s syndrome
split basement membrane

Collagen IV mutation. Nerve deafness and ocular disorders
Symptomes of Nephrotic Syndrome
massive proteinuria
hypoalbuminemia
peripheral and periorbital edema
hyperlipidemia
6 types of nephrotic syndrome
Membranous glomerulonephritis––

Minimal change disease (lipoid nephrosis)––

Focal segmental glomerular sclerosis––

Diabetic nephropathy––

SLE

and Renal Amyloidosis
LM: diffuse capillary and basement membrane thickening
Membranous glomerulonephritis––
A common cause of adult (teenagers and young adults) nephrotic syndrome
Membranous glomerulonephritis––
IF: granular pattern
Membranous glomerulonephritis––

or, acute poststreptococcal glomerulonephritis
EM: "Spike and Dome"
Membranous glomerulonephritis––

Spike and dome - results from extensin of basement membrane between and around the immune deposits; the spikes are basement membrane material, and the domes are immune complex deposits
should be suspected when nephrotic syndrome is accompanied by azotemia
Membranous glomerulonephritis––
10% of Lupus patients have this and it's not SLE Nephrotic syndrome
Membranous glomerulonephritis––
Most common cause of childhood nephrotic syndrome. Responds well to steroids
Minimal change disease (lipoid nephrosis)––
Is characterized by lipid-laden renal cortices
Minimal change disease (LIPOID nephrosis)
LM: normal glomeruli.
Minimal change disease (lipoid nephrosis)––
EM: foot process effacement
Minimal change disease (lipoid nephrosis)––
symptomes of nephritic syndrome
hematuria, hypertension, oliguria, azotemia.

Inflammation
6 types of Nephritic Syndrome
Acute poststreptococcal glomerulonephritis

Rapidly progressive (crescentic) Glomerulonephritis

Goodpasture’s syndrome (type II hypersensitivity)

Membranoproliferative glomerulonephritis

IgA nephropathy (Berger’s disease)

Alport’s syndrome
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"
Acute poststreptococcal glomerulonephritis

(acute proliferative glomerulonephritis)
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"

EM: subepithelial humps

IF granular pattern

Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
EM: subepithelial humps
Acute poststreptococcal glomerulonephritis

(acute proliferative glomerulonephritis)
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"

EM: subepithelial humps

IF granular pattern

Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
IF: granular pattern

"lumpy-bumpy" immunofluorescence (extremely coarse granular immunofluorescence for IgG or C3)
Acute poststreptococcal glomerulonephritis

Membranous Glomerulonephritis also has a granular IF pattern
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"

EM: subepithelial humps

IF granular pattern

Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
Acute poststreptococcal glomerulonephritis

(acute proliferative glomerulonephritis)
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"

EM: subepithelial humps

IF granular pattern

Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
Labs: urinary red cells and red cell casts, azotemia, decreased serum C3, and increased titers of antistrepotococcal antibodies (antistreptolysin O [ASO]), antiDNAase B, and anticationic proteinase as evidence of recent streptococcal infection.
Acute poststreptococcal glomerulonephritis
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"

EM: subepithelial humps

IF granular pattern

Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
Acute poststreptococcal glomerulonephritis labs
Labs: urinary red cells and red cell casts, azotemia, decreased serum C3, and increased titers of antistrepotococcal antibodies (antistreptolysin O [ASO]), antiDNAase B, and anticationic proteinase as evidence of recent streptococcal infection.
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"

EM: subepithelial humps

IF granular pattern

Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
LM and IF: Crescent moon shape
Rapidly progressive (crescentic) Glomerulonephritis
LM and IF: Crescent moon shape

Rapid course to renal failure from one of many causes
Rapid course to renal failure from one of many causes
Rapidly progressive (crescentic) Glomerulonephritis
LM and IF: Crescent moon shape

Rapid course to renal failure from one of many causes
IF: linear pattern
Goodpasture’s syndrome (type II hypersensitivity)

Linear pattern b/c of anti-GBM antibodies
IF: linear pattern. Linear pattern b/c of anti-GBM antibodies

Hemoptysis, hematuria
Hemoptysis, hematuria
Goodpasture’s syndrome (type II hypersensitivity)
IF: linear pattern. Linear pattern b/c of anti-GBM antibodies

Hemoptysis, hematuria
EM: subendothelial humps, "tram track" - double contour
Membranoproliferative glomerulonephritis
EM: subendothelial humps, "tram track" - double contour

Slowly progresses to renal failure
Slowly progresses to renal failure
Membranoproliferative glomerulonephritis
EM: subendothelial humps, "tram track" - double contour

Slowly progresses to renal failure
IF and EM: mesangial deposits of IgA.
IgA nephropathy (Berger’s disease)––
symptomes of nephritic syndrome
hematuria, hypertension, oliguria, azotemia.

Inflammation
6 types of Nephritic Syndrome
Acute poststreptococcal glomerulonephritis

Rapidly progressive (crescentic) Glomerulonephritis

Goodpasture’s syndrome (type II hypersensitivity)

Membranoproliferative glomerulonephritis

IgA nephropathy (Berger’s disease)

Alport’s syndrome
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"
Acute poststreptococcal glomerulonephritis

(acute proliferative glomerulonephritis)
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"

EM: subepithelial humps

IF granular pattern

Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
EM: subepithelial humps
Acute poststreptococcal glomerulonephritis

(acute proliferative glomerulonephritis)
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"

EM: subepithelial humps

IF granular pattern

Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
IF: granular pattern

"lumpy-bumpy" immunofluorescence (extremely coarse granular immunofluorescence for IgG or C3)
Acute poststreptococcal glomerulonephritis

Membranous Glomerulonephritis also has a granular IF pattern
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"

EM: subepithelial humps

IF granular pattern

Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
Acute poststreptococcal glomerulonephritis

(acute proliferative glomerulonephritis)
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"

EM: subepithelial humps

IF granular pattern

Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
Labs: urinary red cells and red cell casts, azotemia, decreased serum C3, and increased titers of antistrepotococcal antibodies (antistreptolysin O [ASO]), antiDNAase B, and anticationic proteinase as evidence of recent streptococcal infection.
Acute poststreptococcal glomerulonephritis
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"

EM: subepithelial humps

IF granular pattern

Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
Acute poststreptococcal glomerulonephritis labs
Labs: urinary red cells and red cell casts, azotemia, decreased serum C3, and increased titers of antistrepotococcal antibodies (antistreptolysin O [ASO]), antiDNAase B, and anticationic proteinase as evidence of recent streptococcal infection.
LM: Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy"

EM: subepithelial humps

IF granular pattern

Most frequently seen in children. Peripheral and periorbital edema. Resolves spontaneously
LM and IF: Crescent moon shape
Rapidly progressive (crescentic) Glomerulonephritis
LM and IF: Crescent moon shape

Rapid course to renal failure from one of many causes
Rapid course to renal failure from one of many causes
Rapidly progressive (crescentic) Glomerulonephritis
LM and IF: Crescent moon shape

Rapid course to renal failure from one of many causes
IF: linear pattern
Goodpasture’s syndrome (type II hypersensitivity)

Linear pattern b/c of anti-GBM antibodies
IF: linear pattern. Linear pattern b/c of anti-GBM antibodies

Hemoptysis, hematuria
Hemoptysis, hematuria
Goodpasture’s syndrome (type II hypersensitivity)
IF: linear pattern. Linear pattern b/c of anti-GBM antibodies

Hemoptysis, hematuria
EM: subendothelial humps, "tram track" - double contour
Membranoproliferative glomerulonephritis
EM: subendothelial humps, "tram track" - double contour

Slowly progresses to renal failure
Slowly progresses to renal failure
Membranoproliferative glomerulonephritis
EM: subendothelial humps, "tram track" - double contour

Slowly progresses to renal failure
IF and EM: mesangial deposits of IgA.
IgA nephropathy (Berger’s disease)––
split basement membrane
Alport's syndrome
Collagen IV mutation, nerve deafness and ocular disorders
Alport's syndrome
Symptomes of Nephrotic Syndrome
massive proteinuria
hypoalbuminemia
peripheral and periorbital edema
hyperlipidemia
LM: Diffuse capillary and basement membrane thickening
Membranous glomerulonephritis––
IF: granular pattern
Membranous glomerulonephritis––

or, acute poststrep glumerulonephritis
EM: "spike and dome" -
Membranous glomerulonephritis––

"Spike and dome" results from extension of basement membrane between and around immune deposits: spikes - basement membrane, domes - immune complex deposits
LM: normal glomeruli.
Minimal change disease (lipoid nephrosis)
EM: foot process effacement
Minimal change disease (lipoid nephrosis)
Most common cause of childhood nephrotic syndrome, responds well to steroids
Minimal change disease (lipoid nephrosis)
A common cause of young adult nephrotic syndrome
Membranous glomerulonephritis––
lipid laden renal cortices
Minimal change disease (lipoid nephrosis)
More severe in HIV pts.

Clinically similar to minimal change disease in older pts.
Focal segmental glomerular sclerosis––
Focal segmental glomerular sclerosis––
Focal segmental glomerular sclerosis––
LM: Kimmelstiel Wilson lesions - nodular accumulations of mesangial matrix material

basement membrane thickening
Diabetic nephropathy––
LM: In membranous glomerulonephritis
pattern, wire-loop lesion with subendothelial
deposits.
SLE

but has 5 patterns of renal involvement. 10% of SLE pts get membranous glomerulonephritis.