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23 Cards in this Set

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Nephrotic Syndrome
massive prOteinuria (>3.5 g/day)
frothy urine
fatty casts
hyperlypidemia
edema
loss of Ig= infections
Membranous glomerulonephritis is also known as
Diffuse memebranous glomerulopathy
LM of Membranous glomerulonephritis
diffuse capillary and GBM thickening
EM of Membranous glomerulonephritis
SPIKE & DOME apperance w subendothelial deposits
IF of Membranous glomerulonephritis
Granular
most common cause of nephrotic syndrome
Membranous glomerulonephritis
Membranous glomerulonephritis caused by
drugs
infections
SLE
solid tumors
Minimal change disease has abnormal glomeruli on LM?
no
EM of Minimal change disease
FOOT PROCESS EFFACEMENT
what is loss in Minimal change disease?
ALBUMIN
Albumin loss in Minimal change disease is due to?
GBM polyanion loss
Minimal change disease is triggered by
Recent infection or immune stimulus
LM of amyloidosis
congo red +
Amyloidosis is associated with
multiple myeloma
TB
RA
chronic conditions
Pathology of Diabetic glomerulopathy
nonenzymatic glycosylation of GBM→ ↑permeability, thickening
nonenzymatic glycosylation of efferent arteriole → ↑GFR → MESENGIAL EXPANSION
Kimmelstiel-Wilson lesion
Diabetic glomerulonephropathy
most common nephrotic syndrome in HIV pts
focal segmental glomerulonephritis
LM of focal segmental glomerulonephritis
segmental sclerosis
hyalinosis
which glomerulonephritis can be presented as nephritic and nephrotic syndrome?
Membranous proliferative glomerulonephritis
Membranous proliferative glomerulonephritis Type I
mesengial ingrowth → GBM splitting →TRAM TRACK apperance
Membranous proliferative glomerulonephritis type II
dense deposits
Associated with C3 nephritic fator
Membranous proliferative glomerulonephritis type II
Associated with HBV
Membranous proliferative glomerulonephritis type I