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17 Cards in this Set

  • Front
  • Back
What is glomerulonephritis?
inflammation of the glomeruli (internal kidney structures)
What are signs and symptoms of glomerulonephritis?
• blood in the urine (dark, rust-colored, or brown urine)
• foamy urine (indicates protein)
• hypertension
What can a urinalysis of a patient w/ glomerulonephritis show?
• dysmorphic RBC
• hematuria
• mild proteinuria (< 2g/day)
• RBC casts
Generally, what are treatment options for patients w/ glomerulonephritis?
• anti-hypertensive meds
• corticosteroids/immunosuppressives
• dietary restrictions (salts, fluids, proteins)
• dialysis or kidney transplantation
What causes focal segmental glomerulosclerosis?
• occurs when scar tissue forms in some of the glomeruli of the kidney
• some glomeruli are scarred, while others remain normal
• only part of an individual glomerulus is damaged
What will immunofluorescence microscopy show in patients with focal segmental glomerulosclerosis?
• IgM deposits
• Current also says C3
What is Goodpasture's syndrome?
• a form of rapidly progressive glomerulonephritis

• involves a progressive decrease in kidney function accompanied by a cough with bloody sputum

• antibodies collect in both the kidney glomerulus and the alveoli in the lungs (causing both glomerulonephritis and bleeding in the lungs)
Although the exact cause of Goodpasture's syndrome is unknown, what are some factors that have been associated with Goodpasture's syndrome?
• family history
• hydrocarbon solvent exposure
• viral respiratory infection (influenza A)
Which type of glomerulonephritis can show iron-deficiency anemia on CBC and hemosiderin-laden (iron-containing) macrophages on sputum stain?
Goodpasture's syndrome
What does kidney biopsy show on patients with Goodpasture's syndrome?
• immune-system deposits with cresent-like deposits
• indicates rapidly progressive glomerulonephritis
What are treatment options for Goodpasture's syndrome?
• corticosteroids
• cyclophosphamide
• plasmapheresis
What is Berger's disease?
inflammation of internal kidney structures and the deposition of IgA antibodies in kidney tissue
How do patients with Berger's disease typically present?
• typically present with hematuria (microscopic or gross)
• hematuria is frequently associated with upper respiratory infection
What are risk factors for Berger's disease?
• personal or family history of IgA nephropathy
• Henoch-Schonlein purpura (a vasculitis that may cause of lesion identical to the lesion of Berger's disease)
What are the two subgroups of membranoproliferative glomerulonephritis?
• Type I (more common)
• Type II
What is the difference between type I and type II MPGN, regarding deposition of antibodies?
• Type I: involves deposits of antibodies in the subendothelial layer of the glomerular membrane
• Type II: involes deposits within the flomerular basement membrane
Which type of MPGN is more rapid, type I or type II?
type II