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35 Cards in this Set
- Front
- Back
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what distinguishes hodgkin lymphoma
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reed-sternberg cell
needs to be of right background .... rs-like cells are often seen in mono |
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how does hodgkin lymphoma spread
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contiguously
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what ages for hodgkin lymphoma
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20-30 .... and ages over 50
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reed sternberg cell
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large cell mirror image nucleii; prominent nucleoli
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orgin of reed sternberg cell
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b lymphocyte
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order of hodgkin spread
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lymph nodes, spleen, liver, marrow
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stage I hodgkin lymphoma
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tumor in one region or two contiguous regions on same side of diaphragm
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stage II HL
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tumor in in more than two regions or 2 non contiguous regions on same side of diaphragm
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stage III HL
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tumor on both sides of diaphragm not extending beyond nodes, spleen
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stage IV HL
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tumor in marrow, lungs or anwhere outside lymph nodes, spleen, wyders ring
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treat low stage HL
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radio therepy
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treat high stage HL
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radio + chemo
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5 year survival low stage HL
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90%
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non HL
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more diverse than HL
85% are B cell origin .... remander are T cell |
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NHL treatmen
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chemo and bone marrow
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classification of NHL
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nodular better than diffuse
small better than large |
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all lymphoid neoplasms arise from a single transformed cell
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TRUE
monoclonal expansion |
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acute luekemia
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rapid with blasts in blood
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chronic leukemia
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indolent with more mature cells
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ALL
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bothe Band T
children spleen and lymph enlargement |
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AML
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adults
increased WBC anemia and thrombocytopenia |
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Auer rods
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cytoplasmic inclusions
AML |
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myloperoxidase
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AML
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CLL
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B cells immunogenically incompetant
monoclonal expression of surface immunoglobulin |
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which Ig is most common in CLL
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IgM
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CML
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immature granulocytes
STEM CELL DISORDER |
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disease difining cytogenitic abnormality
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phliadelphia chromosome in CML
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CML always terminates to acute leukemia
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TRUE
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infiltration of gums
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AML
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multiple myloma most common Ig
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IgG
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multiple myloma
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clonal proliferation of monoclonal plasma cells
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bence jones proteinuria
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excretion of light chain in urine when excess is produced
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proliferating cell in multiple myloma
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plasma cell
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how do you diagnose multiple myloma
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document skeletal lesions and monoclonal protein
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multiple myloma blood
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rbc rouleaux
no plasma in circulation marrow plasma infiltrates single cell and sheet |
