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10 Cards in this Set
- Front
- Back
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cyclophosphamide (Cytoxan) use
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antineoplastic, may also be used to intentionally cause immune suppression for the prophylaxis of organ transplant rejection, and to treat severe rheumatoid arthritis and SLE |
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adverse effects of cyclophosphamide (Cytoxan)
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bone marrow suppression, thrombocytopenia, reversible alopecia, hemorrhagic cystitis, permanent sterility
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methotrexate (Rheumatrex) use |
antineoplastic, severe rheumatoid arthritis, ulcerative colitis, lupus, and psoriasis
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methotrexate black box warning
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causes myelosuppression when used with NSAIDS; hepatotoxic and may cause cirrhosis; pulmonary toxicity may result in acute or chronic interstitial pneumonitis, may cause SJS |
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methotrexate administration alerts
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dilute IV, avoid skin and inhalation exposure, pregnancy X |
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methotrexate overdose treatment
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Leucovorin (folinic acid) helps to "rescue" normal cells from severe bone marrow damage. Urine is also alkalinized to protect the kidneys from methotrexate toxicity |
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Doxorubicin use |
cancer, Kaposi's sarcoma, multiple myeloma |
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doxorubicin adverse effects |
cardiotoxic, hair loss, nausea and vomiting |
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Tamoxifen |
Treats breast cancer, but causes endometrial cancer |
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