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28 Cards in this Set
- Front
- Back
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in moldy peanut, food
produce hepatocarcinogen: aflatoxin B1 |
aspergillus B1
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autosomal recessive
problem with excision repair X2000 risk skin cancer |
xeroderma pigmentosum
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factor that increase metastases
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increase in laminin receptor
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consequence of hMSH2 mutation
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microsatellite instability
( can't repair damage) |
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BCL2 mutation mech
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apoptotic arrest
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mechanism of p53 mutation ( tumor suppressor gene)
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results in cycle not properly arrested in late G1 phase
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true or false
mutation in 1 copy of RB leads to retinoblastoma |
false-
mutation of both strands lead to retinoblastoma (inherit 1 mutated copy, the other copy mutated later--> childhood retinoblastoma) |
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chemotherapy targets what kind of cells
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dividing cells
( most tumors are due to high growth fraction not cell cycle: eg. lymphoma) |
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IL2 mutation leads to
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T cell mutation
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t(14:18)
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BCL2 (anti apoptosis gene)
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in situ carcinoma & basement membrane
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in situ carcinoma is confined to the epithelium and the basement membrane is not breached
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benign version of melanoma
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nevus
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tumor in- mesoderm derived cells of thoracic and abdominal cavity
what chemical can cause this? |
mesothelioma
asbestos |
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alpha fetoprotein is tumor marker for
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liver, testicle cancer
"alpha males live with testicles" |
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mesothelioma
benign or malignant? |
malignant
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vinyl chloride exposure can lead to
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angiosarcoma of the liver (rare)
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aresenic exposure can lead to
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skin, lung cancer
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malignant neoplasm from mesenchymal tissue
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sarcoma
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benign mass at the origin
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hamartoma
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benign mass not at the origin
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choristoma
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origin of adenoma
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epithelial surface
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ABL mutation ( mech)
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increase tyrosine kinase activity
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HER2, MYC
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gene amplification
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activate cytoplasmic kinases
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RAS
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benign mesenchymal neoplasm
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fibroma
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benign, localized, exophytic growth pattern ( grow on fingerlike surface)
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papilloma
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carcinoma most likely travel via
most metastasis in the brain originate from |
lymphatics
lung |
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T or F
sarcomas of the lung are rare (meaning originating from lung) |
True
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