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76 Cards in this Set
- Front
- Back
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Nitrosamines
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Gastric CA, Esophagus
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Cigarette smoke
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Larynx, ling, renal cell carcinoma, transitional cell carcinoma
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Polycyclic aromatic hydrocarbons
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Bronchogenic CA
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Asbestos
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Bronchogenic CA, mesothelioma
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Chromium and nickel
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Bronchogenic CA
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Arsenic
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Squamous cell CA of skin and lung, angiosarcoma of liver
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Vinyl chloride
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Liver angiosarcoma
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Alkalating agents
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Leukemia, lymphoma
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Benzene
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Leukemia, lymphoma
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Napthalene
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Bladder CA
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CCL4
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Liver centrilobular necrosis
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HTLV-1
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Adult T-cell leukemia
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HBV, HCV
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Hepatocellular CA
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EBV
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Burkitt's lymphoma, nasopharyngeal CA
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HPV
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Cervical CA (16, 18)
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HHV-8
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Kaposi sarcoma
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hst-1 & int-2
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Cancer of stomach, breast, bladder and melanoma; produces growth factors; overexpression
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sis
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Astrocytoma; produces PDGF; overexpression
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erb-B1
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SCC of lung; produces EGF receptor; overexpression
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erb-B2
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Breast, ovary and lung CA; produces EGF receptor; amplification
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erb-B3
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Breast; produces EGF receptor; overexpression
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ret
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MEN II & III, medullary thyroid CA; produces glial neurotrophic factor receptor; Point mutation
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abl
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CML, ALL; produces signal transduction proteins; translocation t(9:22), Philadelhpia chromosome
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Ki-ras
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Lung, pancreas and colon; produces GTP binding proteins; Point mutation
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c-myc
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Burkitt lymphoma; produces nuclear regulatory protein; translocation t(8:14). When associated to p53 apoptosis; when associated to bcl-2 inhibits apoptosis
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L-myc
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Small cell lung CA; produces nuclear regulatory protein; amplification
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N-myc
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Neuroblastoma; produces nuclear regulatory protein; amplification
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bcl-1
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Mantle cell lymphoma; produces cyclin D protein; translocation t(11:14)
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CDK4
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Melanoma; produces cdk; amplification
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bcl-2
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Normally prevents apoptosis. Follicular and undiferentiated lymphomas t(14:18). Chromosome 14: Ig heavy chain; chromosome 18 bcl-2
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c-kit
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gastrointestinal stromal tumor
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p53
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Normally prevents a cell with damaged DNA from entering S-phase by inhibiting cyclin/cdk. Colon, breast, CNS, lung. On chromosome 17
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Rb
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Normally prevents a cell from entering S phase. Retinoblastoma, osteogenic sarcoma. Inactivated product by cyclin/cdk. On chromosome 13
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Alpha fetoprotein
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Hepatocellular CA, testicular tumors
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B-hCG
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Trophoblastic tumors, chroriocarcinoma
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Calcitonin
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Medullary CA of thyroid
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CEA
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lung, pancreas, stomach, breast, colon
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CA-125
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Ovarian CA
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CA19-9
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Pancreatic CA
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Placental alkaline phosphatase
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Seminoma
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Prostatic acid phosphatase
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Prostate CA
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PSA
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Prostate CA
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Alkaline phosphatase
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Metastasis to bone, promary billiary cirrhosis
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VHL
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Chr 3p. Von Hippel Lindau, renal cell CA
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WT-1, WT-2
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11p. Wilm tumor
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BRCA-1
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17q. Hereditary breast and ovarian CA
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BRCA-2
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13q. Hereditary breast CA
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APC
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5q. Adenomatous polyps and colon CA
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DCC
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18q. Colon CA
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NF-1
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17q. Neurofibromatosis
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NF-2
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22q. Acoustic neuromas and meningiomas
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Down Syndrome
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ALL, AML
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Xeroderma pigmentosum, albinism
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Squamous cell, basal cell CA, melanoma
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Chronic atrophic gastritis, pernicious anemia, H. pylory
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Gastric adenocarcinoma
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Tuberous sclerosis
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Astrocytoma; produces PDGF; overexpression
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Actinic keratosis
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Squamous cell CA of skin and lung, angiosarcoma of liver
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Barret's esophagus
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Esophageal adenocarcinoma
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Plummer-Vinson syndrome
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Iron deficiency causes atrophic glositis, esophageal webs, anemia, squamous cell CA of esophagus
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Cirrhosis
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Hepatocellular CA
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Ulcerativa colitis
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Colonic adenocarcinoma
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Paget's
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Osteosarcoma
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Immunodeficiency
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Malignant lymphomas
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AIDS
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Non-Hodgikin's, Kaposi
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Dysplastic nevus
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Malignant melanoma
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Radiation
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Sarcoma
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Small cell lung CA paraneoplastic syndromes
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Cushing's (ACTH), SIADH (ADH)
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Squamous cell lung CA paraneoplastic syndrome
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Hypercalcemia (PTH), TGF-b, TNF, IL-1
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Renal cell CA paraneoplastic syndrome
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Polycythemia (EPO)
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Thymoma, Small cell lung CA paraneoplastic syndromes
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Lamber-Eaton (antibodies against presynaptic CA channels at neuromuscular junction)
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Leukemias and lymphomas paraneoplastic syndromes
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Gout (hyperuricemia due to excess nucelic acid turnover)
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Acanthosis nicrans
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Gastric adenocarcinoma
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Carcinoid tumor or medullary thyroid CA paraneoplastic syndromes
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Flushing, diarrhea (serotonin)
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alpha1-antitrypsin
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Hepatocellular CA
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Bence Jones protein
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Multiple Myeloma (Ig light chains in urine)
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MEN-I
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Pituitary (ACTH, Cushings), parathyroid (hypercalcemia), pancreas (zollinger-ellison, insulinoma)
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MEN-II
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medullary thyroid CA, parathyroid adenoma (hypercalcemia), pheocromocytoma (hypertension)
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