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22 Cards in this Set
- Front
- Back
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RAS
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Oncogene
Colon Carcinoma |
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p53
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tumor suppressor gene (several malignancies)
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BCR-ABL
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CML: Chronic Myelogenous Leukemia
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MAGE
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Melanoma
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CEA
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Adenocarcinoma, pancreas, colon, breast, gastric
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AFP (alpha-fetalprotein)
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Hepatocellular carcinoma & embryonal carcinoma
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PSA
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Prostatic Adenocarcinoma
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Calcitonin
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Medullary thyroid carcinoma
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what does the acronym "DADMOVE" stand for?
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It stands for the mechanisms of tumor invasion and metastasis:
D: Detachment A: Adherence D: Degradation of basement membrane MOVE: Motility into the blood or lymph vessels |
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MLH-1, MLH-2
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Hereditary non-polyposis colon cancer
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NF-1
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tumor suppresor gene for Hereditary neurofibromatosis
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APC
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tumor suppresor gene for adenomatous polyposis coli
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DCC
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tumor suppresor gene for deleted in colon cancer
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WT-1
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tumor suppresor gene for Wilm's tumor-1
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BRCA1 & 2
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tumor suppresor gene for Breast Carcinoma
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translocation of the philadelphia chromosome t(9,22) causes:
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CML: Chronic Myeloid Leukemia
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Translocation of t(8,14) causes:
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Burkitt's lymphoma
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Deletion of 13q14 causes
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retinoblastoma
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deletion of 3p causes:
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small cell carcinoma
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gene amplification of N-MYC
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neuroblastoma
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Point mutation of RAS causes:
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colon carcinoma
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Overexpression of BCL2
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B cell lymphoma
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