Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
31 Cards in this Set
- Front
- Back
|
knudson hypothesis
|
a cell can initiate a tumor only when it contains two mutant alleles or a heterozygous individual must mutate the good allele
|
|
|
challeneges
|
tumorigenesis is a multistep process involving activation of oncogenes and inactivation of tumor suppressor genes
|
|
|
haploinsufficiency
|
inactivation of one allele is sufficient to inactivate a genes activity
|
|
|
oncogenes
|
erb2/her2/neu, src, able, bcr-abl, ras, bcl2, fos, jun, myc
|
|
|
growth factor receptors
|
erb2/her2.neu
|
|
|
signaling molecules
|
src, abl, bcr-abl, ras, bcl2
|
|
|
transcirption factors
|
fos, jun ,myc
|
|
|
erb2/her2/neu
|
receptor tyrosine kinase, activated through heterodimerization with other erbB proteins
|
|
|
where is it found
|
breast cancers
|
|
|
what does it do
|
mediates gene transcription and cell proliferation through the ras signaling pathway, promotes cell survival and inhibits apoptosis through the PI2 kinase pathway
|
|
|
abl and src
|
non receptor tyrosine kinases,
|
|
|
bcr-abl
|
encoded on the philadelphia chromosome, CML, potent tyrosine kinase activity
|
|
|
ras
|
gtp bound protein,
|
|
|
bc2
|
b cell lymphoma, govern mitochondria outer membrane permeabiliazation
|
|
|
tumor suppressor gene
|
restran cell growth, involved in cell cycle regulation dna repair or apoptosis
|
|
|
name them
|
rb, p16, p53, smads, apc, brca1/2, pten
|
|
|
rb
|
regulates cell cycle progression by binding to e2f
|
|
|
e6
|
inactivate p53
|
|
|
e7
|
inactivates rb
|
|
|
p53
|
encodes a transcription factor, tumor suppressor,
|
|
|
p21
|
cell cycle arrest
|
|
|
bax
|
apoptosis
|
|
|
gadd45
|
dna repair
|
|
|
mdm2
|
degrade p53
|
|
|
tgf beta
|
activages smad transcription factors
|
|
|
smad4
|
tumor suppressor in pancreatic cancer
|
|
|
wnt/b catenin
|
transcritption factor, in its absenceits phosphorylated and degraded. When its on it inactivates destruction complex
|
|
|
apc
|
tumor suppressor, when mutated results in abberant stabilization of b catenin and short non functional protein
|
|
|
brca
|
tumor suppressor protects against genome instability, mediate dna repair, heriditary breast and ovarian cancers
|
|
|
src
|
oncogenic virus, protooncogene is a non receptor tyrosine kinase
|
|
|
pten
|
a phosphatase that opposes the pi2k-akt oncogenic paathway
|
