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7 Cards in this Set
- Front
- Back
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what are two types of compounds are imitators or carcinogensis
what are these |
direct - need no metabolic activation
indirect - need activation, by liver for example like aflatoxin ->liver cancer
strong electrophiles can bind to DNA |
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direct vs indirect ionizing radiation breaks |
direct - DNA
indirect - water -> DNA |
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what are some of the high risk HPV :
what genes are responsible
what do these genes do |
16, 18, 31 :
E6 and E7 :
inactivate Rb and p53 |
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EBV associated with what |
African burkitt, b cell lymphoma in immunocomprimised, hodgkin, nasopharyngeal |
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what does HBVs HBx do
How else can HBV and HCV lead to liver cancer |
activates Ras via Pyk2 and Src kinases
chronic liver injury leading to hyperplasia |
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how does HHV8 cause kaposi
where is this virus also seen |
cyclin D, IL-6 and BCL-2 encoded
body cavity based lymphoma and Cattleman's disease
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what two cancers does H pylori cause
how does the MALToma start
Which can be treated with antibiotics |
gastric carcinomas and lymphomas
T cell activation leads to polyclonal B cell activation which becomes monoclonal and independent of H pylori at that point
early MALToma |
