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22 Cards in this Set
- Front
- Back
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colostrum
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The first milk produced in the first 24 hours after parturition
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Maternal antibodies
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antibodies that were produced by the mother.
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failure of passive transfer
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failure of maternal antibodies to transfer to neonate either through placenta, colostrum, or milk
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Lymphoid tissue of the fetus
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Thymus appears during 1st trimester
lymphocytes and 2nd lymphoid tissue appear shortly after |
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The fetus' antibody responses include
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Mostly IgM late in gestation.
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Routes of passive transfer
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placental transfer
colstral transfer |
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Placental transfer by species and molecule
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IgG >90% in primates/rodents
<10% in dogs/cats 0% in ruminants, horses |
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Colstral Transfer by species and molecule
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IgG, IgA (IgM)
<10 % in primates, rodents > 90% in dogs, cats 100 % in ruminants |
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Colostrum mostly cIontains
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IgG and IgA
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Systemic absorption of colostrum
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absorbed by intestinal epithelium via receptors
protease low in neonate neonate has protease inhibitors |
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Without systemic absorption, intestinal protection via
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IgA
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During neonates first 24 hours, the expression of ______________decreased to near zero
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Fc receptor
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Maternal antibodies remain in the neonate for
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3 - 5 weeks +/- Half-life
3 - 4 months most is gone |
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Causes of failure of passive transfer; related to the dam
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inadequate colostrum produced
does not allow suckling |
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Causes of failure of passive transfer: Related to neonate
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inadequate intake (weak, etc)
inadequate absorption (often due to delayed intake |
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Clinical signs of failure of passive transfer
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failure to thrive
infectious diseases early in life |
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Management items that may help with diagnosis of FPT
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previous history of FPT
colostrum feeding program |
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Laboratory findings consistent with FPT
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serum IgG concentration
other plasma consitutents in colostrum |
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Prevention of FPT includes
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assist suckling if necessary
maitain immunity to infectious agents in the environment Check colostrum Ig Check calves for plasma Ig |
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Treatment of FPT includes
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if <12 - 13 hours old:oral colostrum
if > 12 - 13 hours old: plasma transfusion anitbiotics and supportive therapy |
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Milk is rich in ______, which is transported across ________
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IgA
mammary epithelium |
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Ruminant milk has high concentration of
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IgG
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