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17 Cards in this Set
- Front
- Back
|
Type
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Gram negative kidney bean shaped diplococci
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Culture
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Chocolate agar
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3 Types of bacteria that cause meningitis
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H flu
Meningococcus Pneumococcus |
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Oxidase
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Positive
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Adhesins
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Varied expression
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Antigenic variation
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Pili
ON/OFF |
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Virulence
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Pilli
Enxotoxin/LPS IgA1 protease Capsule Hemolysin |
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Molecular mimicry
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Decorate surface with PC to look like host
Convergent evolution |
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C-reactive protein
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Restricted to blood
Recognizes only bacteria with PC and opsonizes them |
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PC covering
Benefit Detriment |
Mucosa
Blood |
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Phase variation of PC transferase
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Poly G repeat can be in frame or out of frame making the gene on or off
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Slipped strand mispairing
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Loop forms in DNA that is not copied
Opc's and Opa's If in new strand, genes added Old strand, genes deleted |
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Neisseria profile over time
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Antigenic profile is always changing
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Opa repeats
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Determine if protein is translated
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Opc protein
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Adherence to endothelial cells and can invade cells
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Vaccine
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5 common serotypes covered
B serotype not covered |
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B serotype
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Polymer sialic acid could cause autoimmunity
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