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19 Cards in this Set

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what is the general biology of both N. gonorrhea and N. meningitidis?
gram neg diplococci, coffee bean shaped, transmitted person to person, likes mucosal sites, sensitive to drying, UV, difficulty transporting specimens,most are commensals except gonnorhea, fastidious growth requirements, blood-chocolate agar, species differentiated by carb utilization, aerobic with 5 to 10% CO2 atmosphere, extracellular
what are the virulence factors for neisseria?
pili with antigenic variability, lipooligosaccharide capsule (LPS without the o antigen - antiphag and endtoxin lipid A), opa proteins (mediate binding), Rmp proteins (block serum bacteriocides), Por proteins (porin proteins), iron receptors, A1 protease...
describe general neisseria pathology.
endocytosed on mucosal areas, multiply in columnar epi, go to subepithelial space and set up infection if gonnorrhea, if meningitides goes to blood and meninges.
what is a purulent ocular infection acquired by the neonate at birth of someon with gonnorrhea?
opthalmia neonatorum
proteins gonorrhea uses to adhere and invade cells..
pili and opa to adhere, opa to invade, porin to prevent phagosome from fusing with lysosome
what are the infection sites for men and women with gonorrhea?
pyogenic infection of UG epi, men can have prostatitis and epididymitis. women can have salpingitis and oophoritis and peritonitis
chronic gonorrhea infections lead to what while assymptomatic infections keep what?
sterility... reservoir
what other locations for infection from gonorrhea exist?
pharyngitis and disseminated infections from GU tract through blood to skin or joints
what is gonococcemia?
disseminatedd gonococcal infection or DCI is gonorrhea that goes bacteremic... causes autoimmune response but not sepsis, can cause dermatitis arthritis syndrome with skin pustules, tenosynovitis, asymetric polyarthritis
what are the lab techniques performed to test for gonorrhea?
gram stain and microscopy in your office (note male result is dependable with purulent discharge while female if close to diagnostic, but should still send to lab for culture), culture, genetic probes
what are the treatment methods for gonorrhea?
no penicillin, resistant, as well as resistant to buncha others, use third generation cephalosporin or fluoroquinolone, do in vitro susceptibility test too
what 5 serogroups cause what diseases from N. meninigitidis?
B and C: meningitis and meningococcemia
Y and W125: pneumonia
A: underdeveloped countries have issues
T/F N. meningiditis is not a commensal
F, it is
how is N. meningitidis spread?
person to person via resp. droplets
what are the symptoms of meningococcemiua?
disseminated with throbosis of small BV's, multiorgan involvement, petechial skin lesions that can become larger hemorrhagic lesions, disseminated intravascular coagulation. note pneumonia is a milder form of this disease from this bug.
what are the toxic effects of N. meningitidis?
autolysis of bacteria releases LOS
what are the mortality rates for N. meningitidis?
10% for treated ppl and 100% for untreated ppl
how do you lab diagnose N. meningiditis?
gram stain the CSF, culture is difficult like gonorrhea, but should be done to back up gram stain diagnosis
treatments and preventions for N. meningiditis?
penicillin is choice, must treat others in house prophylactically. Polyvalent polysaccharide vaccine with limited protection for kids over 2