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19 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Morphological vhanges in necrosis and necroptosis due to |
Denaturation of intracellular proteins and enxymatic digestion of cells |
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Increased eosinophilia due to |
Loss of cytoplasmic rna that binds hematoxylin and denaturation of proteins. |
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Glassy homogenous appearance |
Loss of glycogen |
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Myelin figures |
Detached membrane phospholipids. May degrate to fatty acids where calcium soaps may form. |
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Electron Microscopic |
Discontinued membranes, swelling of cell organelles, amorphous densities,myelin figures. |
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Nuclear changes |
Karyolysis pyknosis and karyorrhexsis |
Karyolysis fading basophilia due to dna degradation by endonucleases |
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Large no. Of necrotic cells |
Tissue or organ is said to be necrotic |
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Coagulative necrosis |
Tissue architecture preserved for a few days |
Injury denatures enzymes as well |
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Ischemia causes. .......... necrosis except in .......... |
Coagulative brain |
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In coag. Nec. ....... ....... cells may persist for days or weeks |
Eosinophilic anucleate |
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Liquefactive |
Enxymatic digestion of dead cells. Tissue turns into liquid visvous mads |
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Liq. Nec. Seen in |
Focal microbial fungal infections |
Pathogens induce leukocytes and enzyme liberation from them |
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Pus seen in |
Liq. Nec. |
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Hypoxic death of cells in cns |
Liq. Nec. For unknoen reasons |
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Gangrenous nectosis |
Typically coag.in limb but if bact. Inf. Liq called wet gangrene |
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Fat necrosis |
Release of pancreatic lipases into adipocytes------>saponification Not real type of necrosis |
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Fibrinoid necrosis |
Immune rxns involving b.v. |
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immune complexes together with deposited fibrin |
Bright pink and amorphous in hne |
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Most necrotic cells disappear due to phagocytosis while those not removed |
Provide nidus for dystrophic calcification |
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