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6 Cards in this Set
- Front
- Back
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Atorvastatin
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Statins: Competitive Inhibitions of HMG CoA (analogue). Flourinated. Dec Chol Syn, Inc LDL Receptors. 40-60%LDL Reduction, Inc HDL, Dec Trigly. Inc NO, Dec CRP, Dec Abs w Food. Hepatic Tox. Myoapathy/Rhab worse w Gemfib and [hi]. Not for preg or nursing.
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Pravastatin
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Statins: Competitive Inhibitions of HMG CoA (analogue). Flourinated. Dec Chol Syn, Inc LDL Receptors. 20-40%LDL Reduction, Inc HDL, Dec Trigly. Inc NO, Dec CRP, Dec Abs w Food. Hepatic Tox. Myoapathy/Rhab NOT WORSE w Gemfib and [hi]. Not for preg or nursing.
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Ezetimibe
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Absorption Blocker: Sits in brush border. Use w statins when they don’t work alone. Entero-hep Cycle-22hrT1/2. Antacids ok, Cholestyramine blocks 55%. Liver testes before starting
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Cholestyramine
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Resin: Binds Bile acids. Inc Bile production -> Inc LDLRs + Inc in HMG CoA (use w statins) Drink as Slurry -> Connstapation and Bloat. Possibel vik K and folic acid loss. Dec Absorbtion of some drugs.
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Niacin
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Nicotinamide derivatives. Need 100x normal Dail dose. FLUSHING(take asa 30 mins prior), minor hepato tox. Dec statin by 75%. Inhibit Lypolisis-> Dec FFA. Inhib Trigly and LDL syn. Dec HDL Catab. Not for diabetics or gout
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Gemfibrozil
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Fibrates: PPAR-a ligand. Lowers VLDL. Some Dec LDL & inc HDL & Dec Trigly. Use in Hypertriglyceridiemias!! (dysbetalipoprotemia). Kidney. Myopathy(inc w Statin), Gallstones. Inc Warfairn Effect.
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