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19 Cards in this Set
- Front
- Back
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Acyclovir
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Anti‐Herpes: Acyclic guanosine, HSV‐1, HSV‐2 >> VZV, activated via 3 phosphorylations, Low bioavailability, administered topically oral and via i.v.*, Renal, RES:mutation in viral thymidine kinase
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Ganciclovir
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CMV:(S/P Transplant), Acyclic guanosine, first phos by CMV kinase, CMV (100x > acyclovir), HSV, VZV, HHV‐6, 8, Res: Mut in viral Kinase, Tox:Myelosuppression (major),
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Foscarnet
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Anti‐Herpes/CMV: Pyrophosphate analog (No activation required), Inhibits Viral DNA polymerase, RNA polymerase, HIV RT, i.v. only, strains resistant to acyclovir, Renal tox, Electrolyte abnormailities
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Interferons
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Anti‐Hepatitis: 1st line for Chron HCV, Cytokines (inf Alpha) Induces intracellular signals, For B & C, “flu‐like”, abortifacient
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Ribavirin
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Anti‐Hepatitis: 1st line for Chron HCV, Guanosine analog, Oral, como with interferon, Good for Flu, Hemolytic anemia,
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Telaprevir
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Anti‐Hepatitis: PI, Oral, comb w/peginterferon & ribavirin to treat HCV-1(US), Rash, Hemroids, MDR1/CYP3A4, $$$
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Amantidine
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Anti-Influenza-A: Inhibit virus M2 proton channel-> Block Viral Uncoating, Resistance is COMMON
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Oseltamivir
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Anti-Influenza- A&B: Oral, Neuraminidase inhibitor, sialic acid Analog-> inhibit release of progeny, Ok for Kids >1,
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Zanamivir
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Anti-Influenza- A&B: Inhaled, Neuraminidase inhibitor, sialic acid Analog-> inhibit release of progeny, Ok for Kids >7, Good for resistant strains
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Zidovudine
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HIV: "AZT", NRTI, Competitive inhibition of RT, mitochondrial toxicity, Hyperlipidemia/insulin resistance, **Lactic acidosis w/hepatic steatosis(inc Triglycerides)**, ! Stavudine
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Abacavir
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HIV: Guanosine analog, combo with lamivudine, Myocardial infarction, Hypersensitivity reactions(HLA‐B*5701), Skin rash ~50%
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Tenofovir
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HIV, Chr HBV: NtRTI, Comp inhib HIV RT, Combo w emtricitabine = 1st Line, Renal (tox), Bone loss/Osteopenia
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Lamivudine
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HIV, Chr HBV: cytosine analog, Inhibits RT, Admin with tenofovir,
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Efavirenz
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HIV: NNRTI, t½ 40–55, HAART, Tox: Nightmares/Psychiatric(at start), ! For Preg
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Etravirine
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HIV: NNRTI, No cross resistance to other NNRTIs, Tox: Hypersensitivity
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Ritonavir
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HIV: PI, Inhib CYP3A4, Hepatic Excration, Inc Tri/LDL/liver enzymes, Parastesia, Strange taste, Dose escalation to avoid
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Enfuvirtide
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HIV: Fusion Inhibitor (GP41), HIV1 Only, SC injection, Only for experienced HIV patients
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Maraviroc
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HIV: Fusion Inhibitor (CCR5), Oral, Only for resistant HIV1, Hep tox, 3A4+MDR1
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Raltegravir
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HIV(1&2): Binds Intigrase-block DNA intigration, For resistant HIV
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