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221 Cards in this Set

  • Front
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Benzodiazepinmes
inhibit nerve transmission in the brain, decreases seizure activity.
Diazepam ( Valium)
is drug of choice for status epilepticus
Give Valium at a push rate of
1 mg/min. Do not dilute
Lab effects of CNS depressants
Decreased: WBC, RBC and Platelets
CNS depressants used to
induce sleep, control seizures
Side effects of Barbituates and CNS depressants
sedation, “hang-over” effect, dizziness, unsteady gait, hypotension, nightmares
Toxic levels of the barbiturates can be
lethal
Toxic levels of barbiturates side effects are
bradycardia, respiratory depression, ataxia, slurred speech, confusion, extreme weakness
Primidone (Mysoline)
can cause acute psychosis
Anticonvulsants used to
control seizure activity
Lab effects of Anticonvulsants
Decreased WBC, RBC and platelets. Increased LFT
Hydantoins are the
most frequently prescribed for seizure control
Side effects of the hydantoins
unsteady gait, restlessness, bradycardia, hypotension, Nystagmus (abnormal eye movements), gingival hypertrophy, slurred speech with toxicity
For Gingival hyperplasia
brush the teeth three times daily for dental hygiene
Valproid acid (Depakene, Depakote, Depacon) causes
CNS depressioin. If daily dose ordered, give at bedtime
Carbamazepine (Tegratol) will cause
drowsiness and photosensitivity In some clients
Additional Hydantoins
Ethotoin (Peganone), Mephenytoin (Mesantoin) used for neuropathic pain, Fosphenytoin (Cerebyx), Ethosuximide (Zarontin), Felbamate (Felbatol), Gabapentin (Neurontin), Lamotrigine (Lamictal) also used for Bipolar pts, Levetiracetam (Keppra), Oxycarbazepine (Trileptal), Topiramate (Topamax) also used for weight control, Trimethadione (Tridione), Zonisamide (Zonegran)
Dompaminergic agents
used primary to tx symptoms associatd with Parkinson’s disease.
Muscle rigidity seen in Parkinson’s pts is due to lack of
dopamine
Carbidopa/Levodopa (Sinemet) therapy results seen within
2 – 3 weeks of starting therapy. Some clients may not see improvement for 6 months. Take with meals to reduce N&V
Carbidopa/Levodopa (Sinemet) therapy side effects
Choreiform movements , Dystonic movements
Choreiform movements are
involuntary muscular twitching of the limbs or facial muscles
Dystonic movements are
muscle spasms of tongue, jaw, eyes and neck
Selegiline (Carbex, Eldepryl) can cause
MAOI – induced hypertensive crisis
Amatadine (Symmetrel) can cause
pronounced orthostatic hypotension and increased risk off infection
Additional agents
Bromocriptine (Parlodel), Carbidopa (Lodosyn), Entacapone (Comtan), Levodopa (Dopar, Larodopa), Pergolide (Permax), Pramipexole (Mirapex), Ropinirole (Requip), Tolcapone (Tasmar)
Central Acting Anticholinergics
used in the tx of other symptoms in Parkinson’s Disease, such as excessive sweating, salivation, and orthostatic hypotension.
Central Acting Anticholinergic meds side effects
SLUDGE DECREASED
SLUDGE
* salivation, *lacrimation, *Urination, *defecation, *GI upset, *Emesis
While taking Cogentin (Benztropine)
pt should avoid driving or operating machinery
Additional Central acting Anticholinergics
Biperiden (Akineton), Diphenhydramine (Benadryl), Procyclidine (Kemadrin) , Trihexyphenidyl (Artane)
Cholinasterase inhibitors
used to tx Alzheimer’s Disease
Cholinergic agents used to
tx Myasthenia Gravis and to diagnose MG
When used to tx MG
administering 30 minutes before meals will promote chewing and swallowing, thus improving pt’s nutritional status.
Cholinergic and Cholinasterase inhibitors
Endrophonium ( Tensilon), Neostigmine (Prostigmin), Pyridostigmine (Mestinon), Physostigmine (Antillirium), Rivastigmine tartrate (Exelon)
Migraine agents used that are Adrenergic Blockers
Clonidine HCI (Catapress), Egotamine (Cafatine, Cafergot), Propanolol (Inderal), Sumatriptan (Imitrex)
Migraine agents used that are Serotonin agonist
Almotriptan(Axert), Naratriptan(Amerge), Rizatriptan(Maxalt), Sumatriptan (Imitrex), Zolmitriptan (Zomig)
Psychomotor stimulants
Amphetamine, Dexmethylphenidate (Focalin), Dextroamphetamine sulfate (Dexedrine), Methamphetamine (Desoxyn), Methylphenidate (Concerta, Metadate, Ritalin), Pemoline (Cylert)
Methylphenidate (Concerta, Metadate, Ritalin) also used as
appetite stimulant in the elderly
Frontal lobe responsible for
insight, judgment, and planning, personality, memory, concentration and motor control of speech.
Aphasia and personality changes are due to changes in
the frontal lobe
Speech center is in the
left frontal lobe in most people
Temporal lobe is
responsible for hearing, language and comprehension
Test temporal lobe by testing
recall of memories, and evaluation of speech and hearing problems.
Occipital lobe responsible for
vision
Changes in vision can show defects in
occipital lobe
Cerebellum is responsible for
balance, equilibrium and coordination.
Test cerebellum function by
observing gait changes and running the foot down the leg and watch balance
Reticular activating system
responsible for level of consciousness
Limbic system
responsible for feelings and emotions
Brain stem
responsible for vital functions , observe vital signs to monitor
Left side of brain
responsible for language (LEFT FOR LANGUAGE)
Right side of brain
responsible for judgement
Cranial Nerves and their functions
* I Olfactory (Smell), * II Optic (Vision), *III Oculomotor (eye movements), *IV Trochlear (eye movements), *V Trigeminal (innervates the cornea), *VI Abducens (eye movements), * VII Facial (smile), *VIII Acoustic (hearing, vestibular), *IX Glossopharyngeal (swallow), * X Vagus (swallow), *XI Spinal (shrug shoulders), *XII Hypoglossal (extends the tongue)
Parkinson’s Disease is
chronic progressive disorder that is characterized by joing and muscle rigidity, bradykinesis, tremors and abnormalities in posture.
The chemical imbalance in Parkinsons’ Disease is
not enough dopamine and normal amount of acetylcholine. Onset is gradual usually after 50 years of age.
General clinical manifestation in Parkinsons
dysarthia with poor articulation in speech, Mask like expression, Pill rolling, Non-intention termors of the upper limbs which occur at rest or may occur with voluntary movements, sometimes with the head being involved, Side to side twitching, Pill rolling aggrevated by stress.
Bradykinesis
loss of normal arm swing with walking, decreased blinking, loss of ability to swallow, blank expression, difficulty initiating movements
Use Passive ROM
with acute illness in Parkinson’s.
Stooped posture
shuffling, propulsive gait
Muscle rigidity
increased resistance with passive movement, cog wheel, jerky slow movements.
Parkinson’s Treatments
Caribidopa/Levodopa (Sinemet) used frequently. Bulk forming products, high fiber and stool softeners to promote bowel function. Avoid use of laxatives.
Parkinson’s Interventions
Raised toilet seat to increase independence, maintain muscle function during acute illnesses such as pneumonia, use POM.
Multiple Sclerosis
a chronic disease which affects the brain and spinal cord and leads to a wide variety of symptoms including weakness and difficulties with coordination and speech.
MS is considered to be
autoimmune disease.
MS often presents with
visual disturbances such as diplopia and blurred vision due to optic nerve lesions
MS symptoms involving motor dysfunction
usually begins in one or more extremeties, typically occurs on one half of the body or in the lower extremeties with weakness progressing to spastic paralysis.
Fatigue is precipitated or exacerbated by
high or warm temperatures
Bowel and Bladder dysfunction occurs in
90% of MS patients , high fiber and fluid promoted to avoid constipation and urinary problems
MS is more common in
women
MS progression is not
“orderly”
Drug Therapy for MS
ACTH, Cortisone, Cytoxan, Immunosuppresent drugs
Spinal cord injuries
compression injuries will have pain at level of compression
Disability in spinal cord injuries
based on location of the injury, most common in complete injury
Cervical injuries
loss of the use of arms and hand, may have shoulder use, C3 – C5, respiratory status a major concern. The cervical plexus innervates the diaphragm.
Thoracic injuries
lose control of cough and normal bowel function. T1 injury has normal biceps function (work on arm strength), T3 injury can do personal hygiene independently.
Lumbar
Lose control of bladder, legs and feet
Paraplegia is the paralysis of
lower part of the body
Qaudriplegia is the paralysis of
all four extremeties.
Central cord syndrome is an
acute cervical injury of the central cord. It is the most common incomplete lesion of the spinal cord.
Central cord syndrome shows
greater motor loss in the upper extremities as compared to the lower one, Loss of sensation below the level of injury is variable.
Anterior cord syndrome is
the anterior part of the cord is damaged due to certain type of injury.
Anterior cord syndrome function lost
motor, pain and temperature sensations below the level of injury
Anterior cord syndrome function present
proprioception and coarse sensations below the level of injury.
Brown-Sequard is
hemisection of the cord.
In Brown-Sequard on the same side of injury
deficit of movement, loss of touch and vibration on that side.
In Brown-Sequard on the opposite side of injury
loss of pain and temperature
Autonomic Dysreflexia
triggered by bladder or bowel distention, restrictive clothing and skin stimulation such as pressure area or blanket across the toes. Presents as severe hypertension, bradycardia and headache.
Autonomic Dysreflexia above the injury
Vasodilation, flushed, warm, diaphoretic and distended neck veins.
Autonomic Dysreflexia below the injury
vasoconstriction, pale, cool, no sweating.
Spinal shock
hypotension is displayed, imperative to reverse ASAP.
Permanent paralysis can occur if spinal cord is compressed for
12 -24 hours.
Areflexia
characterizes spinal shock
Clinical correlation and care of spinal cord injured clients includes
Acute injuries tx with Solu-Medrol (100kg pt. = 3000 mg dose)
Bladder spasms and reflex incontinence problem for spinal injuries
caffeine in the diet can contribute to spasms, discourage caffeine intake.
SCI (spinal cord injury) pts are prone to
UTI’s. one of the most common causes of death in those with SCI due to UTI becoming sepsis. SCI patient prone to skin breakdown.
SCI patients may have sexual relations but different due to the following
men may have reflex erections and may not ejaculate. Women can have abductor spasms.
Halo vests used for cervical injuries
provides stability to the cervical spine, is heavy so limits pt. trunk flexibility. Carry correct wrench size in case of emergency, pin care daily, use of walker and rubber soled shoes may help prevent falls and injury.
Myasthenia Gravis
chronic autoimmune disease with varying degrees of weakness of the skeletal or voluntary muscles of the body due to deficiency of acetylcholine, often due to the production of autoantibodies that attack acetylcholine receptors.
MG clinical Manifestations
weakness of muscles innervated by the cranial nerves, Diplopia and ptosis common, Sleepy appearance due to facial muscle involvement, weakness increases during periods of activity and improves after periods of rest, bedrest often relieves symptoms.
MG most severe complication
respiratory failure
MG treatments
Cholinergic medications, may need to increase meds during periods of increased activity, (pyridostgmine *Mestinon) and (neostigmine *Prostigmin) are given. Steriods added if other meds are not effective.
MG symptoms
Bladder and respiratory infections are common recurring problem. Must use aspiration precautions with MG pts.
Plasmapheresis
used to separate plasma from the blood elements so the plasma proteins that contain the antibodies may be removed. May give temporary relief to clients with actual or impending respiratory failure.
Thymectomy
possible treatment and can be a cure.
Tensilon Test is used
to diagnose the disease and differentiate between cholinergic crises and MG crisis.
Cholinegic crisis
when pt is getting too much of the cholinergic medications used to treat MG. Will produce a Negative test
MG crisis
when pt. is not getting enough of the medications based on metabolic needs. Will produce a positive test.
Clinical manifestations of increased ICP early indicators
Changes in LOC, restlessness, irritability, confusion.
ICP pupil changes
unequal or slower, pinpoint, fixed and dilation as herniation occurs
Cushings Triad
Vitals are opposite of shock. Decreased pulse, irregular respirations, widening pulse pressure.
ICP changes In motor response
Decoriticate (good),Decerebrate (bad)
ICP manifestations in infants
sunset eyes, high pitched cry
ICP temperature
low grade with injury, hyperpyrexia with damage to or pressure on hypothalamus.
Normal ICP
5 – 15 mm3
Nursing interventions
HOB elevated 30 – 45 % , try not to restrain clients, Avoid narcotics due to change in LOC, Can also change pupil responses. Control hyperglycemia and fever which causes cerebral edema and increased ICP. Minimize stimuli. Restrict activities which inc. pressure in head. Don’t routinely suction.
Pharmacological interventions to decrease or avoid ICP
steroids (Prednison, Decadron *dexamethasone). Mannitol will be used to dec. fluid in brain and dec. ICP. Prophylactic antibiotics if a surgical client or CSF leakage and agents used to reduce secretions such as atropine or glycopyrrolate (Robinul)
Mannitol duration of action
12 hours, monitor uring output Q 1 hr.
Anticonvulsants used in ICP
to prevent and/or control seizures is phenytoin (Dilantin)
In ICP monitor for CSF leakage
test positive for glucose and gives a “halo” appearance on paper, increased risk for meningitis and can indicate a deteriorating condition.
Maximize cerebral perfusion by monitoring
CO2 levels. Alkalosis leads to vasoconstriction and dec. blood low. Control the respiratory rate.
Herniation is the complication if ICP is not controlled
pressure on the brain stem could lead to brain death. Pupils are unequal/pinpoint/dilated
Craniotomy
surgical procedure where part of skull is removed in order to access the brain.
Craniotomy done for
brain lesions or blood vessel abnormalities, traumatic brain injury, (TBI), and to implant brain stimulators to treat Parkinson’s and epilepsy. May be infratentorial or supratentorial approach for brain tumor.
Head of bed elevation
Supra is elevated for supratentorial, Supre = HOB elevated, Infra is flat for infratentorial. Infra = HOB flat.
Hydrocephalus
enlargement of the cranium caused by abnormal accumulation of CSF within the cerebral ventricular system resulting in an increase in head size and weight and an increase in ICP.
Hydrocephalus interventions
support head and neck, feed with HOB up, May need ventricular peritoneal shunt.
Ventricular peritoneal shunt care
shunt has delicate valves, do not pump the shunt unless ordered, this changes pressure in the ventricles. Do not place on side of shunt because pressure can cause skin breakdown. Need to do seizure precautions before and after the surgery, anticipate steroid use to decrease cerebral edema, HOB at 45 degrees with large pillow under the head and shoulders. Any sign of clear nasal drainage, notify physician ASAP.
Seizures
excessive activity in the cerebral cortex of the brain.
Seizures are uncommon before
age 2
Convulsions are
spasmodic muscle movements seen in those with seizures
Tonic seizure is
tight
Clonic seizure is
contraction
Suction at bedside to help
handle secretions
May follow seizure
postictal state
May precede seizure
aura
Absence seizure
petit mal has a short LOC. Minor hand face and eye movements.
Absence seizures may be seen in
kids and adolescents. Blank facial expressions may be seen.
Myoclonic seizure
brief, uncontrollable, jerking movements caused by muscle contraction.
Partial seizure
from part of brain, focal activity is seen.
Tourette’s disorder
inherited neuropsychiatric disorder with onset in childrhood and characterized by presence of multiple physical (motor) tics and at least one vocal (phonic) tic.
Motor tics
usually involve the head. Most frequent is eye blinking and tongue protrusion. May involve the torso and extremeties. Touching, squatting, hopping, skipping, retracing steps and twirling while walking may be seen.
Verbal tics
barks, grunts, yelps, clicks, snorts, sniffs and coughs.
Coprolalia
saying obscenities and is seen in a small number of cases.
Cerebravascular accidents (CVA’s)
reduction of blood flow to a part of brain structure due to occlusion of blood vessel by a clot or the rupture of a vessel as a result of hypertension or an abnormality of the vessel itself such as an aneurysm.
Meds given in CVA’s
Steriods may be given to decrease cerebral edema and decrease damage, H2 blockers to prevent peptic ulcers.
Transient Ischemic Attacks (TIA’s)
temporary episodes of neurological dysfunction.
Thrombotic stroke
slower onset of symptoms. Often related to Atherosclerosis.
Embolic stroke
sudden onset of symptoms, often related to A-fib and A-flutter.
Hemorrhagic stroke
usually a sudden onset of symptoms. Often related to hypertension.
Causes of hemorrhagic strokes
cerebral aneurysm, AV malformation, intracerebral hemorrhage, subarachnoid hemorrhage.
Cerebral aneurysm
growing aneurysm may present with minor headache, intermittent blurred vision, cranial nerve palsy or dilated pupils.
Signs and symptoms of growing aneurysms are
subtle
Aneurysms larger than 10 mm in diameter have a
50% chance of bleeding
If aneurysms are leading put client
on strict bedrest
Grade II aneurysm is
mild bleed in which client remains alert but has nuchal rigidity with possible neurological deficits, depending on area of bleed.
Aneurysm precautions
quite environment, don’t bend over, deep breathing, no coughing, no stimulants including visitors and caffeine, avoid valsalva such as straining or holding breath when getting out o bed.
Arteriovenous malformation
congenital abnormal communication between arterial and venous channels resulting from a failure to develop a capillary network in the embryonic brain.
Clinical manifestations in arteriovenous malformation
hemorrhage, seizures, headache and progressive neurologic deficits.
Intracerebral hemorrhage
bleeding into the subarachnoid space
Manifestations of subarachnoid bleeds
headache, nuchal rigidity and photophobia. Crainial nerve deficits especially CN II and sometimes IV an V, causing diplopia and blurred vision.
Subarachnoid bleeds give
nimodipine (Nimotop) which is a CCB.
Rehabilitation is essential however
NO ROM for the first 24 hours after a stroke.
Will frequently see
emotional lability with strokes.
Hemiplegia
total paralysis of one side of body usually occurring with stroke
Hemiparesis
is weakness or slight paralysis on one side of the body.
Parasthesia
an abnormal sensation such a burning or prickling usually caused by nerve damage. Paresthesia = prickling.
Peripheral neuropathy
painful condition of the nerves of the hands and feet due to damage of the peripheral nerves.
Homonymous hemianopia
loss of one half the visual field.
Apraxia
absence of purposeful movements in the absence of motor problems, ( Can’t make the X)
Dysartthia
difficulty articulating speech
Dysphagia
difficulty swallowing
Dysphasia
difficulty with speech and verbal comprehension
Aphasia
absence of speech (s for sound)
Agraphia
absence of ability to write
Alexia
absence of the ability to read (can’t read the Lexus)
Meningitis
inflammation of the meninges which are the protective membranes covering the brain and spinal cord.
Kernig’s sign
physical sign of meningitis. Severe stiffness of the hamstrings causes an inability to straighten the leg when the hip is flexed to 90 degrees. (they have difficulty Kicking out) (K for kernig)
Brudzinski’s sign
flexing the chin down to the chest causes pain and the client will pull the legs up into a fetal position. (Bothering them they curl up to the fetal position) (B for Brudzinski)
Test the CSF by
lumbar puncture
Signs of bacterial meningitis
Increased ICP , Cloudy CSF, Increased protein > 45 mg/l, Decreased Glucose < 45 mg / L.
May see SIADH with
fluid retention, cerebral edema, and dilutional hyponatremia.
Bell’s Palsy
unilateral inflammation of the facial nerve (cranial nerve VII), resolves in several weeks to months, affects movement of the eyelid, tearing and taste, mimics stroke.
Nursing interventions in Bell’s Palsy
chew on unaffected side, gently massage the face, wear dark glasses when out, use an eye patch at night to protect the eye.
Trigeminal neuralgia
inflammation of the trigeminal nerve causing extreme pain and muscle spasms in the face. Pain is present with stimulation such as brushing teeth and chewing food.
Trigeminal neuralgia nursing interventions
teach chewing foods easily, no extreme temperatures. Nerve injections with alcohol done and considered temporary measure that lasts 6 – 18 months
Microvascular decompression of blood vessels at nerve root is
surgical procedure done for trigeminal neuraligia. May recur in 30% of clients within 6 years of procedure. Nursing procedure is to treat these patients like a craniotomy after surgery.
Guillian-Barre’
acute, autoimmune disorder affecting the peripheral nervous system usually triggered by an acute infectious process (respiratory or gastrointestinal) in the 1-4 weeks before the onset of symptoms. It is occasionally triggered by vaccinations or surgery. Involves the cranial nerves which are part of the peripheral nervous system.
Symptoms of Guillian-Barre’
ascending paralysis, at risk for hypotension, hypertension and bradycardia, at risk for DVTs, at risk for respiratory failure, dysphagia will be seen, elevated protein in the CSF, treatable with plasmapheresis followed by immmunoglobulins and supportive care.
Amyotrophic lateral sclerosis (ALS)
progressive and usually fatal disorder caused by degeneration of the motor neurons. The disorder causes muscular weakness and atrophy throughout the body although mental function is usually spared. Dementia may result in certain situations.
ALS presents with
descending paralysis and is a permanent condition.
Basilar skull fracture
linear skull fracture at the base of the skull from a blow to the back of the head or sudden deceleration of the torso but not the head as in a motor vehicle crash. The fracture is between the occipital and temporal bones.
Acceleration injury
head in motion
Deceleration injury
head suddenly stops
Basilar skull fracture manifestations
bleeding from the ear, rhinorrhea, battle’s sign and raccoon eyes.
Meniere’s disease
disorder of the inner ear that can affect hearing and balance.
Clinical manifestations of Meniere’s disease
vertigo, tinnitus, and progressive hearing loss, usually in one ear. Caused by increase in volume and pressure of the endolymph of the inner ear.
Nursing interventions in Meniere’s
salt and fluid restrictions. Pt. should avoid sudden head changes.
MRI
no metal on client or in the room
Myelogram
monitor for signs of meningitis afterwards
EEG
use tincture of benzoin to get electrodes to stick if diaphorectic
EMG
needles inserted into the affected muscles during the test. Done to assess the electrical activity and determine whether symptoms are primarily musculoskeletal or neurological.
Lumbar puncture and spinal tap
give fluids for headache after spinal tap or spinal anesthetic. Leading over bedside table for adults, side lying and curled into a ball for children.
Glucose levels in bacterial meningitis
decreased.
Level of Consciousness is best indicator of
neurological status
Confusion
unable to think clearly and rapidly
Disorientation
unable to recognize place or person
Obtunded
sleeps unless aroused
Stupor
requires considerable amount of stimulation to arous
Corneal reflex
safest way to test is to use a drop of saline instead of a whisp of cotton, If absent, instill artificial tears PRN
Hearing
last sense to go
Glasgow coma scale
Maximum of 15, < 7 reflects coma state, < 5 organ donation should be discussed
Assessed behaviors in GCS
eye opening, most appropriate verbal response, Most integrated motor response
Eye opening in GCS
Spontaneous 4, to verbal stimulus 3, to pain 2, none 1
Verbal response in GCS
Oriented 5, confused 4, Inappropriate words 3, Incoherent 2, None 1
Motor Response in GCS
Obeys commands 6, Localizes pain 5, withdraws from pain 4, Flexion (decorticate)3, Extension (cerebrate) 2, None 1
Babinski reflex
should be positive in children under 2 yrs of age. Negative in all others. Positive indicates pyramidal tract disease where there is trouble with the relay of impulses. Bleed in the brain could have a positive response.
Negative babinski is
normal. Think of a baby. . . when you put your finger in theirs, they curl down and hold onto your finger. This is a normal response, it is a negative response.
Moro reflex
startle reflex which is normal in newborns and disappears between 3 – 4 months. If present longer, suspect neurological disease such as Cerebral palsy.
Stepping reflex
normal in newborns and disappears about 3 – 4 weeks at which time it is replaced by a more deliberate action
Cremasteric reflex
superficial reflex that tests L1 and L2. Stimulating the reflex is useful in emptying a spastic bladder after a spinal cord disruption above the sacral segment.